|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 23 4617-4626, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
JF de Celis, DM Tyler, J de Celis and SJ Bray
Department of Genetics and Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK. jdc@mole.bio.cam.ac.uk
The legs of Drosophila are divided into segments along the proximodistal axis by flexible structures called joints. The separation between segments is already visible in the imaginal disc as folds of the epithelium, and cells at segment boundaries have different morphology during pupal development. We find that Notch is locally activated in distal cells of each segment, as demonstrated by the restricted expression of the Enhancer of split mbeta gene, and is required for the formation of normal joints. The genes fringe, Delta, Serrate and Suppressor of Hairless, also participate in Notch function during leg development, and their expression is localised within the leg segments with respect to segment boundaries. The failure to form joints when Notch signalling is compromised leads to shortened legs, suggesting that the correct specification of segment boundaries is critical for normal leg growth. The requirement for Notch during leg development resembles that seen during somite formation in vertebrates and at the dorsal ventral boundary of the wing, suggesting that the creation of boundaries of gene expression through Notch activation plays a conserved role in co-ordinating growth and patterning.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Mulinari and U. Hacker Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis Development, December 1, 2009; 136(23): 3875 - 3880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Benitez, S. J. Bray, I. Rodriguez, and I. Guerrero Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development Development, April 1, 2009; 136(7): 1211 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Maeda, M. Takemura, M. Umemori, and T. Adachi-Yamada E-cadherin prolongs the moment for interaction between intestinal stem cell and its progenitor cell to ensure Notch signaling in adult Drosophila midgut Genes Cells, December 1, 2008; 13(12): 1219 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. I. Pueyo, R. Lanfear, and J. P. Couso From the Cover: Ancestral Notch-mediated segmentation revealed in the cockroach Periplaneta americana PNAS, October 28, 2008; 105(43): 16614 - 16619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun, L. Smith, A. Armento, and W.-M. Deng Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling J. Cell Biol., September 8, 2008; 182(5): 885 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. del Alamo and M. Mlodzik Self-modulation of Notch signaling during ommatidial development via the Roughened eye transcriptional repressor Development, September 1, 2008; 135(17): 2895 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ma, M. Boulton, B. Zhao, C. Connon, J. Cai, and J. Albon A Role for Notch Signaling in Human Corneal Epithelial Cell Differentiation and Proliferation Invest. Ophthalmol. Vis. Sci., August 1, 2007; 48(8): 3576 - 3585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Thomas and D. J. van Meyel The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression Development, February 1, 2007; 134(3): 591 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Molnar, A. Lopez-Varea, R. Hernandez, and J. F. de Celis A Gain-of-Function Screen Identifying Genes Required for Vein Formation in the Drosophila melanogaster Wing Genetics, November 1, 2006; 174(3): 1635 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kwon, Z. Han, E. N. Olson, and D. Srivastava MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling PNAS, December 27, 2005; 102(52): 18986 - 18991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Lai, F. Roegiers, X. Qin, Y. N. Jan, and G. M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development, May 15, 2005; 132(10): 2319 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Soler, M. Daczewska, J. P. Da Ponte, B. Dastugue, and K. Jagla Coordinated development of muscles and tendons of the Drosophila leg Development, December 15, 2004; 131(24): 6041 - 6051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Pueyo and J. P. Couso Chip-mediated partnerships of the homeodomain proteins Bar and Aristaless with the LIM-HOM proteins Apterous and Lim1 regulate distal leg development Development, July 1, 2004; 131(13): 3107 - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fuss, F. Josten, M. Feix, and M. Hoch Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila Development, April 1, 2004; 131(7): 1587 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Beermann, M. Aranda, and R. Schroder The Sp8 zinc-finger transcription factor is involved in allometric growth of the limbs in the beetle Tribolium castaneum Development, February 15, 2004; 131(4): 733 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. de Celis Ibeas and S. J. Bray Bowl is required downstream of Notch for elaboration of distal limb patterning Development, December 15, 2003; 130(24): 5943 - 5952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Witt, W.-J. Won, V. Hurez, and C. A. Klug Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells J. Immunol., September 15, 2003; 171(6): 2783 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koelzer and T. Klein A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila Development, May 1, 2003; 130(9): 1973 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Chern and K.-W. Choi Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc Development, September 1, 2002; 129(17): 4005 - 4013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Erkner, A. Roure, B. Charroux, M. Delaage, N. Holway, N. Core, C. Vola, C. Angelats, F. Pages, L. Fasano, et al. Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development Development, January 3, 2002; 129(5): 1119 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rauskolb The establishment of segmentation in the Drosophila leg Development, November 15, 2001; 128(22): 4511 - 4521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. R. Buckles, C. Rauskolb, J. L. Villano, and F. N. Katz four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg Development, September 15, 2001; 128(18): 3533 - 3542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Casares and R. S. Mann The Ground State of the Ventral Appendage in Drosophila Science, August 24, 2001; 293(5534): 1477 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Kerber, I Monge, M Mueller, P. Mitchell, and S. Cohen The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development Development, January 4, 2001; 128(8): 1231 - 1238. [Abstract] [PDF]
|
|
|
|
|
|
I Monge, R Krishnamurthy, D Sims, F Hirth, M Spengler, L Kammermeier, H Reichert, and P. Mitchell Drosophila transcription factor AP-2 in proboscis, leg and brain central complex development Development, January 4, 2001; 128(8): 1239 - 1252. [Abstract] [PDF]
|
|
|
|
|
|
E. Lai, R Bodner, and J. Posakony The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family Development, January 8, 2000; 127(16): 3441 - 3455. [Abstract] [PDF]
|
|
|
|
|
|
N Lawrence, T Klein, K Brennan, and A Martinez Arias Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila Development, January 7, 2000; 127(14): 3185 - 3195. [Abstract] [PDF]
|
|
|
|
|
|
A Baonza, J. de Celis, and A Garcia-Bellido Relationships between extramacrochaetae and Notch signalling in Drosophila wing development Development, January 6, 2000; 127(11): 2383 - 2393. [Abstract] [PDF]
|
|
|
|
|
|
E. Jockusch, C Nulsen, S. Newfeld, and L. Nagy Leg development in flies versus grasshoppers: differences in dpp expression do not lead to differences in the expression of downstream components of the leg patterning pathway Development, January 4, 2000; 127(8): 1617 - 1626. [Abstract] [PDF]
|
|
|
|
|
|
S. Artavanis-Tsakonas, M. D. Rand, and R. J. Lake Notch Signaling: Cell Fate Control and Signal Integration in Development Science, April 30, 1999; 284(5415): 770 - 776. [Abstract] [Full Text]
|
|
|
|
|
|
T Ikeya and S Hayashi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea Development, January 10, 1999; 126(20): 4455 - 4463. [Abstract] [PDF]
|
|
|
|
|
|
S. Bishop, T Klein, A. Arias, and J. Couso Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch Development, January 7, 1999; 126(13): 2993 - 3003. [Abstract] [PDF]
|
|
|
|
|
|
M Llimargas The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates Development, January 6, 1999; 126(11): 2355 - 2364. [Abstract] [PDF]
|
|
|
|
|
|
A. Baonza and A. Garcia-Bellido Notch signaling directly controls cell proliferation in the Drosophila wing disc PNAS, March 14, 2000; 97(6): 2609 - 2614. [Abstract] [Full Text] [PDF]
|
|
