|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 24 5091-5104, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
D Acampora, V Avantaggiato, F Tuorto, P Briata, G Corte and A Simeone
International Institute of Genetics and Biophysics, CNR, Via G. Marconi 12, Italy.
Otx1 and Otx2, two murine homologs of the Drosophila orthodenticle (otd) gene, contribute to brain morphogenesis. In particular Otx1 null mice are viable and show spontaneous epileptic seizures and abnormalities affecting the dorsal telencephalic cortex. Otx2 null mice die early in development and fail in specification of the rostral neuroectoderm and proper gastrulation. In order to determine whether Otx1(-/- )and Otx2(-/-) highly divergent phenotypes reflect differences in temporal expression or biochemical activity of OTX1 and OTX2 proteins, the Otx2-coding sequence was replaced by a human Otx1 full-coding cDNA. Homozygous mutant embryos recovered anterior neural plate and proper gastrulation but failed to maintain forebrain-midbrain identities, displaying a headless phenotype from 9 days post coitum (d.p.c.) onwards. Unexpectedly, in spite of the RNA distribution in both visceral endoderm (VE) and epiblast, the hOTX1 protein was synthesized only in the VE. This VE-restricted translation was sufficient to recover Otx2 requirements for specification of the anterior neural plate and proper organization of the primitive streak, thus providing evidence that the difference between Otx1 and Otx2 null mice phenotypes originates from their divergent expression patterns. Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification.
This article has been cited by other articles:
|
|
 |
|
  S. T. Waters and M. Lewandoski A threshold requirement for Gbx2 levels in hindbrain development. Development, May 1, 2006; 133(10): 1991 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li, Z. Lao, and A. L. Joyner New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression Development, April 15, 2005; 132(8): 1971 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rhinn, K. Lun, M. Luz, M. Werner, and M. Brand Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling Development, March 15, 2005; 132(6): 1261 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kurokawa, N. Takasaki, H. Kiyonari, R. Nakayama, C. Kimura-Yoshida, I. Matsuo, and S. Aizawa Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm Development, July 15, 2004; 131(14): 3307 - 3317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Puelles, A. Annino, F. Tuorto, A. Usiello, D. Acampora, T. Czerny, C. Brodski, S.-L. Ang, W. Wurst, and A. Simeone Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain Development, May 1, 2004; 131(9): 2037 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimozaki, K. Nakashima, H. Niwa, and T. Taga Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures Development, June 1, 2003; 130(11): 2505 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Viczian, R. Vignali, M. E. Zuber, G. Barsacchi, and W. A. Harris XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina Development, April 1, 2003; 130(7): 1281 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, Y. Liang, W. Deng, K. Shimizu, A. M. Ashique, E. Li, and Y.-P. Li The zinc-finger protein CNBP is required for forebrain formation in the mouse Development, April 1, 2003; 130(7): 1367 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hide, J. Hatakeyama, C. Kimura-Yoshida, E Tian, N. Takeda, Y. Ushio, T. Shiroishi, S. Aizawa, and I. Matsuo Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice Development, March 11, 2003; 129(18): 4347 - 4357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Pfeffer, B. Payer, G. Reim, M. P. di Magliano, and M. Busslinger The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers Development, March 3, 2003; 129(2): 307 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mukhopadhyay, A. Teufel, T. Yamashita, A. D. Agulnick, L. Chen, K. M. Downs, A. Schindler, A. Grinberg, S.-P. Huang, D. Dorward, et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation Development, February 1, 2003; 130(3): 495 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Glavic, J. L. Gomez-Skarmeta, and R. Mayor The homeoprotein Xiro1 is required for midbrain-hindbrain boundary formation Development, January 4, 2002; 129(7): 1609 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. H. Li and A. L. Joyner Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development, December 15, 2001; 128(24): 4979 - 4991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Martinez-Barbera, M. Signore, P. P. Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden, and A. Simeone Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2 Development, December 1, 2001; 128(23): 4789 - 4800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation Development, December 1, 2001; 128(23): 4801 - 4813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development Development, October 15, 2001; 128(20): 4021 - 4034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Boyl, M. Signore, D. Acampora, J. P. Martinez-Barbera, C. Ilengo, A. Annino, G. Corte, and A. Simeone Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR Development, August 1, 2001; 128(15): 2989 - 3000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Perea-Gomez, K. Lawson, M Rhinn, L Zakin, P Brulet, S Mazan, and S. Ang Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo Development, January 3, 2001; 128(5): 753 - 765. [Abstract] [PDF]
|
|
|
|
|
|
A Liu and A. Joyner EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region Development, January 1, 2001; 128(2): 181 - 191. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu Patterning of the mammalian cochlea PNAS, October 24, 2000; 97(22): 11707 - 11713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huelsken, R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice J. Cell Biol., February 7, 2000; 148(3): 567 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Foley, I Skromne, and C. Stern Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast Development, January 9, 2000; 127(17): 3839 - 3854. [Abstract] [PDF]
|
|
|
|
|
|
J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation Development, January 6, 2000; 127(11): 2433 - 2445. [Abstract] [PDF]
|
|
|
|
|
|
A Liu, K Losos, and A. Joyner FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate Development, January 11, 1999; 126(21): 4827 - 4838. [Abstract] [PDF]
|
|
|
|
|
|
U Borello, M Coletta, S Tajbakhsh, L Leyns, E. De Robertis, M Buckingham, and G Cossu Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos Development, January 10, 1999; 126(19): 4247 - 4255. [Abstract] [PDF]
|
|
|
|
|
|
H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu Otx1 and Otx2 activities are required for the normal development of the mouse inner ear Development, January 6, 1999; 126(11): 2335 - 2343. [Abstract] [PDF]
|
|
|
|
|
|
M Hidalgo-Sanchez, A Simeone, and R. Alvarado-Mallart Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon Development, January 6, 1999; 126(14): 3191 - 3203. [Abstract] [PDF]
|
|
|
|
|
|
D Acampora, V Avantaggiato, F Tuorto, P Barone, M Perera, D Choo, D Wu, G Corte, and A Simeone Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes Development, January 4, 1999; 126(7): 1417 - 1426. [Abstract] [PDF]
|
|
