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Development, Vol 125, Issue 4 691-699, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
G Shaulsky, D Fuller and WF Loomis
Center for Molecular Genetics, Department of Biology, University of California San Diego, La Jolla, CA 92093, USA.
A cAMP-specific phosphodiesterase was found that is stimulated by binding to the regulatory subunit of cAMP-dependent protein kinase, PKA-R, from either Dictyostelium or mammals. The phosphodiesterase is encoded by the regA gene of Dictyostelium, which was recovered in a mutant screen for strains that sporulate in the absence of signals from prestalk cells. The sequence of RegA predicts that it will function as a member of a two-component system. Genetic analyses indicate that inhibition of the phosphodiesterase results in an increase in the activity of PKA, which acts at a check point for terminal differentiation. Conserved components known to affect memory, learning and differentiation in flies and vertebrates suggest that a similar circuitry functions in higher eukaryotes.
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