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Development, Vol 125, Issue 4 753-765, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
X Xu, M Weinstein, C Li, M Naski, RI Cohen, DM Ornitz, P Leder and C Deng
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions of FGF/FGFR2 signals in development, we have mutated FGFR2 by deleting the entire immunoglobin-like domain III of the receptor. We showed that murine FGFR2 is essential for chorioallantoic fusion and placenta trophoblast cell proliferation. Fgfr2(DeltaIgIII/DeltaIgIII) embryos displayed two distinct defects that resulted in failures in formation of a functional placenta. About one third of the mutants failed to form the chorioallantoic fusion junction and the remaining mutants did not have the labyrinthine portion of the placenta. Consequently, all mutants died at 10-11 days of gestation. Interestingly, Fgfr2(DeltaIgIII/DeltaIgIII) embryos do not form limb buds. Consistent with this defect, the expression of Fgf8, an apical ectodermal factor, is absent in the mutant presumptive limb ectoderm, and the expression of Fgf10, a mesenchymally expressed limb bud initiator, is down regulated in the underlying mesoderm. These findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
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D. L. Miller, S. Ortega, O. Bashayan, R. Basch, and C. Basilico Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice Mol. Cell. Biol., March 15, 2000; 20(6): 2260 - 2268. [Abstract] [Full Text]
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I Ruvinsky and J. Gibson-Brown Genetic and developmental bases of serial homology in vertebrate limb evolution Development, January 12, 2000; 127(24): 5233 - 5244. [Abstract] [PDF]
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R Haraguchi, K Suzuki, R Murakami, M Sakai, M Kamikawa, M Kengaku, K Sekine, H Kawano, S Kato, N Ueno, et al. Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation Development, January 6, 2000; 127(11): 2471 - 2479. [Abstract] [PDF]
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H. Makarenkova, M Ito, V Govindarajan, S. Faber, L Sun, G McMahon, P. Overbeek, and R. Lang FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development Development, January 6, 2000; 127(12): 2563 - 2572. [Abstract] [PDF]
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M Weaver, N. Dunn, and B. Hogan Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis Development, January 6, 2000; 127(12): 2695 - 2704. [Abstract] [PDF]
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D. Rice, T Aberg, Y Chan, Z Tang, P. Kettunen, L Pakarinen, R. Maxson, and I Thesleff Integration of FGF and TWIST in calvarial bone and suture development Development, January 5, 2000; 127(9): 1845 - 1855. [Abstract] [PDF]
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A. Moon, A. Boulet, and M. Capecchi Normal limb development in conditional mutants of Fgf4 Development, January 3, 2000; 127(5): 989 - 996. [Abstract] [PDF]
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L De Moerlooze, B Spencer-Dene, J Revest, M Hajihosseini, I Rosewell, and C Dickson An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis Development, January 2, 2000; 127(3): 483 - 492. [Abstract] [PDF]
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E. Arman, R. Haffner-Krausz, M. Gorivodsky, and P. Lonai Fgfr2 is required for limb outgrowth and lung-branching morphogenesis PNAS, October 12, 1999; 96(21): 11895 - 11899. [Abstract] [Full Text] [PDF]
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O. Wendling, P. Chambon, and M. Mark Retinoid X receptors are essential for early mouse development and placentogenesis PNAS, January 19, 1999; 96(2): 547 - 551. [Abstract] [Full Text] [PDF]
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S Iseki, A. Wilkie, and G. Morriss-Kay Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault Development, January 12, 1999; 126(24): 5611 - 5620. [Abstract] [PDF]
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A. Thomson and G. Cunha Prostatic growth and development are regulated by FGF10 Development, January 8, 1999; 126(16): 3693 - 3701. [Abstract] [PDF]
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K Hashimoto, Y Yokouchi, M Yamamoto, and A Kuroiwa Distinct signaling molecules control Hoxa-11 and Hoxa-13 expression in the muscle precursor and mesenchyme of the chick limb bud Development, January 6, 1999; 126(12): 2771 - 2783. [Abstract] [PDF]
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P. Hunter, B. Swanson, M. Haendel, G. Lyons, and J. Cross Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development Development, January 3, 1999; 126(6): 1247 - 1258. [Abstract] [PDF]
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I Munoz-Sanjuan, B. Simandl, J. Fallon, and J Nathans Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development Development, January 1, 1999; 126(2): 409 - 421. [Abstract] [PDF]
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M Bei and R Maas FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development Development, January 11, 1998; 125(21): 4325 - 4333. [Abstract] [PDF]
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F. Lovicu and P. Overbeek Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice Development, January 9, 1998; 125(17): 3365 - 3377. [Abstract] [PDF]
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M Weinstein, X Xu, K Ohyama, and C. Deng FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung Development, January 9, 1998; 125(18): 3615 - 3623. [Abstract] [PDF]
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J. Gibson-Brown, S. Agulnik, L. Silver, L Niswander, and V. Papaioannou Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development Development, January 7, 1998; 125(13): 2499 - 2509. [Abstract] [PDF]
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