|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 4 753-765, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
X Xu, M Weinstein, C Li, M Naski, RI Cohen, DM Ornitz, P Leder and C Deng
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions of FGF/FGFR2 signals in development, we have mutated FGFR2 by deleting the entire immunoglobin-like domain III of the receptor. We showed that murine FGFR2 is essential for chorioallantoic fusion and placenta trophoblast cell proliferation. Fgfr2(DeltaIgIII/DeltaIgIII) embryos displayed two distinct defects that resulted in failures in formation of a functional placenta. About one third of the mutants failed to form the chorioallantoic fusion junction and the remaining mutants did not have the labyrinthine portion of the placenta. Consequently, all mutants died at 10-11 days of gestation. Interestingly, Fgfr2(DeltaIgIII/DeltaIgIII) embryos do not form limb buds. Consistent with this defect, the expression of Fgf8, an apical ectodermal factor, is absent in the mutant presumptive limb ectoderm, and the expression of Fgf10, a mesenchymally expressed limb bud initiator, is down regulated in the underlying mesoderm. These findings provide direct genetic evidence that FGF/FGFR2 signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction.
This article has been cited by other articles:
|
|
 |
|
  P. Lu, Y. Yu, Y. Perdue, and Z. Werb The apical ectodermal ridge is a timer for generating distal limb progenitors Development, April 15, 2008; 135(8): 1395 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Cotton, M. K. O'Bryan, and B. T. Hinton Cellular Signaling by Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) in Male Reproduction Endocr. Rev., April 1, 2008; 29(2): 193 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium Development, October 15, 2007; 134(20): 3615 - 3625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Shams, E. Rohmann, V. P. Eswarakumar, E. D. Lew, S. Yuzawa, B. Wollnik, J. Schlessinger, and I. Lax Lacrimo-Auriculo-Dento-Digital Syndrome Is Caused by Reduced Activity of the Fibroblast Growth Factor 10 (FGF10)-FGF Receptor 2 Signaling Pathway Mol. Cell. Biol., October 1, 2007; 27(19): 6903 - 6912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Papadaki, M. Alexiou, G. Cecena, M. Verykokakis, A. Bilitou, J. C. Cross, R. G. Oshima, and G. Mavrothalassitis Transcriptional Repressor Erf Determines Extraembryonic Ectoderm Differentiation Mol. Cell. Biol., July 15, 2007; 27(14): 5201 - 5213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sugiura, Y.-Q. Su, F. J. Diaz, S. A. Pangas, S. Sharma, K. Wigglesworth, M. J. O'Brien, M. M. Matzuk, S. Shimasaki, and J. J. Eppig Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells Development, July 15, 2007; 134(14): 2593 - 2603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Eswarakumar and J. Schlessinger Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3 PNAS, March 6, 2007; 104(10): 3937 - 3942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lin, G. Liu, Y. Zhang, Y.-P. Hu, K. Yu, C. Lin, K. McKeehan, J. W. Xuan, D. M. Ornitz, M. M. Shen, et al. Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis Development, February 15, 2007; 134(4): 723 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kojima, J.-H. Chang, and D. T. Azar Proangiogenic Role of ephrinB1/EphB1 in Basic Fibroblast Growth Factor-Induced Corneal Angiogenesis Am. J. Pathol., February 1, 2007; 170(2): 764 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Kuslak, J. L. Thielen, and P. C. Marker The mouse seminal vesicle shape mutation is allelic with Fgfr2 Development, February 1, 2007; 134(3): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Li, D. A. Scott, E. Hatch, X. Tian, and S. L. Mansour Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development Development, January 1, 2007; 134(1): 167 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Eswarakumar, F. Ozcan, E. D. Lew, J. H. Bae, F. Tome, C. J. Booth, D. J. Adams, I. Lax, and J. Schlessinger Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis PNAS, December 5, 2006; 103(49): 18603 - 18608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Nakazawa, H. Nagai, M. Shin, and G. Sheng Negative regulation of primitive hematopoiesis by the FGF signaling pathway Blood, November 15, 2006; 108(10): 3335 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Newman, S. J. Muh, R. H. Hovhannisyan, C. C. Warzecha, R. B. Jones, W. L. McKeehan, and R. P. Carstens Identification of RNA-binding proteins that regulate FGFR2 splicing through the use of sensitive and specific dual color fluorescence minigene assays RNA, June 1, 2006; 12(6): 1129 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Harvey and M. P. O. Logan sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth. Development, March 1, 2006; 133(6): 1165 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van Nes, W. de Graaff, F. Lebrin, M. Gerhard, F. Beck, and J. Deschamps The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice Development, February 1, 2006; 133(3): 419 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Morin-Kensicki, B. N. Boone, M. Howell, J. R. Stonebraker, J. Teed, J. G. Alb, T. R. Magnuson, W. O'Neal, and S. L. Milgram Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65 Mol. Cell. Biol., January 1, 2006; 26(1): 77 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lours and S. Dietrich The dissociation of the Fgf-feedback loop controls the limbless state of the neck Development, December 15, 2005; 132(24): 5553 - 5564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Li, X. Xu, D. K. Nelson, T. Williams, M. R. Kuehn, and C.-X. Deng FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis Development, November 1, 2005; 132(21): 4755 - 4764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Verheyden, M. Lewandoski, C. Deng, B. D. Harfe, and X. Sun Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning Development, October 1, 2005; 132(19): 4235 - 4245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, R. Xiao, F. Yang, B. O. Karim, A. J. Iacovelli, J. Cai, C. P. Lerner, J. T. Richtsmeier, J. M. Leszl, C. A. Hill, et al. Abnormalities in cartilage and bone development in the Apert syndrome FGFR2+/S252W mouse Development, August 1, 2005; 132(15): 3537 - 3548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Coumoul, V. Shukla, C. Li, R.-H. Wang, and C.-X. Deng Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference Nucleic Acids Res., June 24, 2005; 33(11): e102 - e102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Watson and J. C. Cross Development of Structures and Transport Functions in the Mouse Placenta Physiology, June 1, 2005; 20(3): 180 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gotoh, K. Manova, S. Tanaka, M. Murohashi, Y. Hadari, A. Lee, Y. Hamada, T. Hiroe, M. Ito, T. Kurihara, et al. The Docking Protein FRS2{alpha} Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development Mol. Cell. Biol., May 15, 2005; 25(10): 4105 - 4116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gotoh, M. Ito, S. Yamamoto, I. Yoshino, N. Song, Y. Wang, I. Lax, J. Schlessinger, M. Shibuya, and R. A. Lang Tyrosine phosphorylation sites on FRS2{alpha} responsible for Shp2 recruitment are critical for induction of lens and retina PNAS, December 7, 2004; 101(49): 17144 - 17149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tanimoto, M. Yokozeki, K. Hiura, K. Matsumoto, H. Nakanishi, T. Matsumoto, P. J. Marie, and K. Moriyama A Soluble Form of Fibroblast Growth Factor Receptor 2 (FGFR2) with S252W Mutation Acts as an Efficient Inhibitor for the Enhanced Osteoblastic Differentiation Caused by FGFR2 Activation in Apert Syndrome J. Biol. Chem., October 29, 2004; 279(44): 45926 - 45934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cully, A. Elia, S.-H. Ong, V. Stambolic, T. Pawson, M.-S. Tsao, and T. W. Mak grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice PNAS, October 26, 2004; 101(43): 15358 - 15363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawakami, C. R. Esteban, T. Matsui, J. Rodriguez-Leon, S. Kato, and J. C. I. Belmonte Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos Development, October 1, 2004; 131(19): 4763 - 4774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Parekh, A. McEwen, V. Barbour, Y. Takahashi, J. E. Rehg, S. M. Jane, and J. M. Cunningham Defective Extraembryonic Angiogenesis in Mice Lacking LBP-1a, a Member of the grainyhead Family of Transcription Factors Mol. Cell. Biol., August 15, 2004; 24(16): 7113 - 7129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schmahl, Y. Kim, J. S. Colvin, D. M. Ornitz, and B. Capel Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination Development, August 1, 2004; 131(15): 3627 - 3636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Stumpo, N. A. Byrd, R. S. Phillips, S. Ghosh, R. R. Maronpot, T. Castranio, E. N. Meyers, Y. Mishina, and P. J. Blackshear Chorioallantoic Fusion Defects and Embryonic Lethality Resulting from Disruption of Zfp36L1, a Gene Encoding a CCCH Tandem Zinc Finger Protein of the Tristetraprolin Family Mol. Cell. Biol., July 15, 2004; 24(14): 6445 - 6455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ohkubo, A. O. Uchida, D. Shin, J. Partanen, and F. M. Vaccarino Fibroblast Growth Factor Receptor 1 Is Required for the Proliferation of Hippocampal Progenitor Cells and for Hippocampal Growth in Mouse J. Neurosci., July 7, 2004; 24(27): 6057 - 6069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Coumoul, W. Li, R.-H. Wang, and C. Deng Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system Nucleic Acids Res., June 15, 2004; 32(10): e85 - e85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Myers, L. B. Corson, J. Rossant, and J. C. Baker Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling Mol. Cell. Biol., May 15, 2004; 24(10): 4255 - 4266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nogami, H. Suzuki, H. Habuchi, N. Ishiguro, H. Iwata, and K. Kimata Distinctive Expression Patterns of Heparan Sulfate O-Sulfotransferases and Regional Differences in Heparan Sulfate Structure in Chick Limb Buds J. Biol. Chem., February 27, 2004; 279(9): 8219 - 8229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Boulet and M. R. Capecchi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod Development, January 15, 2004; 131(2): 299 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Reinhold, D. G. McEwen, and M. C. Naski Fibroblast Growth Factor Receptor 3 Gene: Regulation by Serum Response Factor Mol. Endocrinol., January 1, 2004; 18(1): 241 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Logan Finger or toe: the molecular basis of limb identity Development, December 29, 2003; 130(26): 6401 - 6410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Alvarez, M. T. Alonso, V. Vendrell, L. C. Zelarayan, P. Chamero, T. Theil, M. R. Bosl, S. Kato, M. Maconochie, D. Riethmacher, et al. Requirements for FGF3 and FGF10 during inner ear formation Development, December 22, 2003; 130(25): 6329 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gorivodsky and P. Lonai Novel roles of Fgfr2 in AER differentiation and positioning of the dorsoventral limb interface Development, November 15, 2003; 130(22): 5471 - 5479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Jiang and J. R. Couchman Perlecan and Tumor Angiogenesis J. Histochem. Cytochem., November 1, 2003; 51(11): 1393 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Treichel, F. Schock, H. Jackle, P. Gruss, and A. Mansouri mBtd is required to maintain signaling during murine limb development Genes & Dev., November 1, 2003; 17(21): 2630 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Bell, C. M. Schreiner, R. R. Waclaw, K. Campbell, S. S. Potter, and W. J. Scott From the Cover: Sp8 is crucial for limb outgrowth and neuropore closure PNAS, October 14, 2003; 100(21): 12195 - 12200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. W. Draper, D. W. Stock, and C. B. Kimmel Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development Development, October 1, 2003; 130(19): 4639 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dell'Era, R. Ronca, L. Coco, S. Nicoli, M. Metra, and M. Presta Fibroblast Growth Factor Receptor-1 Is Essential for In Vitro Cardiomyocyte Development Circ. Res., September 5, 2003; 93(5): 414 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chhokar and A. L. Tucker Angiogenesis: Basic Mechanisms and Clinical Applications Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 253 - 280. [Abstract] [PDF]
|
|
|
|
|
|
D. Thumkeo, J. Keel, T. Ishizaki, M. Hirose, K. Nonomura, H. Oshima, M. Oshima, M. M. Taketo, and S. Narumiya Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death Mol. Cell. Biol., July 15, 2003; 23(14): 5043 - 5055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yu, J. Xu, Z. Liu, D. Sosic, J. Shao, E. N. Olson, D. A. Towler, and D. M. Ornitz Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth Development, July 1, 2003; 130(13): 3063 - 3074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Liu, E. Nakamura, V. Knezevic, S. Hunter, K. Thompson, and S. Mackem A role for the mesenchymal T-box gene Brachyury in AER formation during limb development Development, April 1, 2003; 130(7): 1327 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Hebert, M. Lin, J. Partanen, J. Rossant, and S. K. McConnell FGF signaling through FGFR1 is required for olfactory bulb morphogenesis Development, March 15, 2003; 130(6): 1101 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Eswarakumar, E. Monsonego-Ornan, M. Pines, I. Antonopoulou, G. M. Morriss-Kay, and P. Lonai The IIIc alternative of Fgfr2 is a positive regulator of bone formation Development, March 10, 2003; 129(16): 3783 - 3793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Harada, T. Toyono, K. Toyoshima, M. Yamasaki, N. Itoh, S. Kato, K. Sekine, and H. Ohuchi FGF10 maintains stem cell compartment in developing mouse incisors Development, March 5, 2003; 129(6): 1533 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Yeh, M. Igarashi, A. V. Eliseenkova, A. N. Plotnikov, I. Sher, D. Ron, S. A. Aaronson, and M. Mohammadi Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors PNAS, March 4, 2003; 100(5): 2266 - 2271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Agarwal, J. N. Wylie, J. Galceran, O. Arkhitko, C. Li, C. Deng, R. Grosschedl, and B. G. Bruneau Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo Development, February 1, 2003; 130(3): 623 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mood, R. Friesel, and I. O. Daar SNT1/FRS2 Mediates Germinal Vesicle Breakdown Induced by an Activated FGF Receptor1 in Xenopus Oocytes J. Biol. Chem., August 30, 2002; 277(36): 33196 - 33204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ohbayashi, M. Shibayama, Y. Kurotaki, M. Imanishi, T. Fujimori, N. Itoh, and S. Takada FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis Genes & Dev., April 1, 2002; 16(7): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Garrity, S. Childs, and M. C. Fishman The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome Development, January 10, 2002; 129(19): 4635 - 4645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Mailleux, B. Spencer-Dene, C. Dillon, D. Ndiaye, C. Savona-Baron, N. Itoh, S. Kato, C. Dickson, J. P. Thiery, and S. Bellusci Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo Development, January 1, 2002; 129(1): 53 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pizette, C. Abate-Shen, and L. Niswander BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb Development, November 15, 2001; 128(22): 4463 - 4474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Revest, R. K. Suniara, K. Kerr, J. J. T. Owen, and C. Dickson Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb J. Immunol., August 15, 2001; 167(4): 1954 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Lu, E. C. Swindell, W. D. Sierralta, G. Eichele, and C. Thaller Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud Development, July 1, 2001; 128(13): 2451 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
