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Development, Vol 125, Issue 5 845-856, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
M Rhinn, A Dierich, W Shawlot, RR Behringer, M Le Meur and SL Ang
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/Universite Louis Pasteur, Strasbourg, France.
The homeobox gene Otx2 is a mouse cognate of the Drosophila orthodenticle gene, which is required for development of the brain, rostral to rhombomere three. We have investigated the mechanisms involved in this neural function and specifically the requirement for Otx2 in the visceral endoderm and the neuroectoderm using chimeric analysis in mice and explant recombination assay. Analyses of chimeric embryos composed of more than 90% of Otx2-/- ES cells identified an essential function for Otx2 in the visceral endoderm for induction of the forebrain and midbrain. The chimeric studies also demonstrated that an anterior neural plate can form without expressing Otx2. However, in the absence of Otx2, expression of important regulatory genes, such as Hesx1/Rpx, Six3, Pax2, Wnt1 and En, fail to be initiated or maintained in the neural plate. Using explant-recombination assay, we could further demonstrate that Otx2 is required in the neuroectodem for expression of En. Altogether, these results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectoderm for the specification of forebrain and midbrain territories.
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J. Zoltewicz, N. Plummer, M. Lin, and A. Peterson oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1 Development, January 11, 1999; 126(22): 5085 - 5095. [Abstract] [PDF]
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P. Tam and K. Steiner Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo Development, January 11, 1999; 126(22): 5171 - 5179. [Abstract] [PDF]
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M Rhinn, A Dierich, M Le Meur, and S Ang Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain Development, January 10, 1999; 126(19): 4295 - 4304. [Abstract] [PDF]
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A Perea-Gomez, W Shawlot, H Sasaki, R. Behringer, and S Ang HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo Development, January 10, 1999; 126(20): 4499 - 4511. [Abstract] [PDF]
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H Morsli, F Tuorto, D Choo, M. Postiglione, A Simeone, and D. Wu Otx1 and Otx2 activities are required for the normal development of the mouse inner ear Development, January 6, 1999; 126(11): 2335 - 2343. [Abstract] [PDF]
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K Hentges, K Thompson, and A Peterson The flat-top gene is required for the expansion and regionalization of the telencephalic primordium Development, January 4, 1999; 126(8): 1601 - 1609. [Abstract] [PDF]
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H Chang, D Huylebroeck, K Verschueren, Q Guo, M. Matzuk, and A Zwijsen Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects Development, January 4, 1999; 126(8): 1631 - 1642. [Abstract] [PDF]
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E Coucouvanis and G. Martin BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo Development, January 2, 1999; 126(3): 535 - 546. [Abstract] [PDF]
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Y Suda, J Nakabayashi, I Matsuo, and S Aizawa Functional equivalency between Otx2 and Otx1 in development of the rostral head Development, January 2, 1999; 126(4): 743 - 757. [Abstract] [PDF]
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H Knoetgen, C Viebahn, and M Kessel Head induction in the chick by primitive endoderm of mammalian, but not avian origin Development, January 2, 1999; 126(4): 815 - 825. [Abstract] [PDF]
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H Shamim, R Mahmood, C Logan, P Doherty, A Lumsden, and I Mason Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain Development, January 2, 1999; 126(5): 945 - 959. [Abstract] [PDF]
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D Acampora, V Avantaggiato, F Tuorto, P Briata, G Corte, and A Simeone Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation Development, January 12, 1998; 125(24): 5091 - 5104. [Abstract] [PDF]
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L. Zakin, B. Reversade, B. Virlon, C. Rusniok, P. Glaser, J.-M. Elalouf, and P. Brulet Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos PNAS, December 19, 2000; 97(26): 14388 - 14393. [Abstract] [Full Text] [PDF]
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