|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 125, Issue 5 929-935, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
KE Latham and C Sapienza
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. keith@cleo.fels.temple.edu
It is now well established that genomic imprinting effects in mammals require a combination of epigenetic modifications imposed during gametogenesis and additional modifications imposed after fertilization. The earliest post-fertilization modifications to be imposed on the genome are those thought to be mediated by factors in the egg cytoplasm. Strain-dependent differences in the actions of these egg modifiers in mice reveal an important potential for genetic variability in the imprinting process, and also provide valuable genetic systems with which to identify some of the factors that participate in imprinting. Previous studies documented a strain-dependent difference in the modification of paternal genome function between the C57BL/6 and DBA/2 mouse strains. This difference is revealed as a difference in developmental potential of androgenetic embryos produced with eggs from females of the two strains by nuclear transplantation. The specificity of the effect for the paternal genome is consistent with an effect on imprinted genes. The egg phenotype is largely independent of the genotype of the fertilizing sperm, and the C57BL/6 phenotype is dominant in reciprocal F1 hybrids. Genetic studies demonstrated that the difference in egg phenotypes between the two strains is most likely controlled by two independently segregating loci. We now report the results of experiments in which the egg phenotypes of the available BxD recombinant inbred mouse strains have been determined. The results of the analysis are consistent with the two locus model, and we have identified candidate chromosomal locations for the two loci. These data demonstrate clearly that differences in how the egg cytoplasm modifies the incoming paternal genome are indeed genetically determined, and vary accordingly.
This article has been cited by other articles:
|
|
 |
|
  Z. Han, Y. G. Chung, S. Gao, and K. E. Latham Maternal Factors Controlling Blastomere Fragmentation in Early Mouse Embryos Biol Reprod, March 1, 2005; 72(3): 612 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ibanez, D. F Albertini, and E. W Overstrom Effect of genetic background and activating stimulus on the timing of meiotic cell cycle progression in parthenogenetically activated mouse oocytes Reproduction, January 1, 2005; 129(1): 27 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Chamberlain, K. A. Johnstone, A. J. DuBose, T. A. Simon, M. S. Bartolomei, J. L. Resnick, and C. I. Brannan Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion mice Hum. Mol. Genet., December 1, 2004; 13(23): 2971 - 2977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Levy, K. Elder, and Y. Menezo Cytoplasmic transfer in oocytes: biochemical aspects Hum. Reprod. Update, May 1, 2004; 10(3): 241 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hiendleder, K. Prelle, K. Bruggerhoff, H.-D. Reichenbach, H. Wenigerkind, D. Bebbere, M. Stojkovic, S. Muller, G. Brem, V. Zakhartchenko, et al. Nuclear-Cytoplasmic Interactions Affect In Utero Developmental Capacity, Phenotype, and Cellular Metabolism of Bovine Nuclear Transfer Fetuses Biol Reprod, April 1, 2004; 70(4): 1196 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gao, E. Czirr, Y. G. Chung, Z. Han, and K. E. Latham Genetic Variation in Oocyte Phenotype Revealed Through Parthenogenesis and Cloning: Correlation with Differences in Pronuclear Epigenetic Modification Biol Reprod, April 1, 2004; 70(4): 1162 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.M. Acton, A. Jurisicova, I. Jurisica, and R.F. Casper Alterations in mitochondrial membrane potential during preimplantation stages of mouse and human embryo development Mol. Hum. Reprod., January 1, 2004; 10(1): 23 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Hawes, C. Sapienza, and K. E. Latham Ooplasmic donation in humans: The potential for epigenic modifications Hum. Reprod., April 1, 2002; 17(4): 850 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Obata, Y. Ono, H. Akuzawa, O.Y. Kwon, M. Yoshizawa, and T. Kono Post-implantation development of mouse androgenetic embryos produced by in-vitro fertilization of enucleated oocytes Hum. Reprod., April 1, 2000; 15(4): 874 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wang and K. E. Latham Translation of Maternal Messenger Ribonucleic Acids Encoding Transcription Factors During Genome Activation in Early Mouse Embryos Biol Reprod, April 1, 2000; 62(4): 969 - 978. [Abstract] [Full Text]
|
|
