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Development, Vol 125, Issue 6 1025-1036, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
M Studer, A Gavalas, H Marshall, L Ariza-McNaughton, FM Rijli, P Chambon and R Krumlauf
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
In the developing vertebrate hindbrain Hoxa1 and Hoxb1 play important roles in patterning segmental units (rhombomeres). In this study, genetic analysis of double mutants demonstrates that both Hoxa1 and Hoxb1 participate in the establishment and maintenance of Hoxb1 expression in rhombomere 4 through auto- and para-regulatory interactions. The generation of a targeted mutation in a Hoxb1 3' retinoic acid response element (RARE) shows that it is required for establishing early high levels of Hoxb1 expression in neural ectoderm. Double mutant analysis with this Hoxb1(3'RARE) allele and other targeted loss-of-function alleles from both Hoxa1 and Hoxb1 reveals synergy between these genes. In the absence of both genes, a territory appears in the region of r4, but the earliest r4 marker, the Eph tyrosine kinase receptor EphA2, fails to be activated. This suggests a failure to initiate rather than maintain the specification of r4 identity and defines new roles for both Hoxb1 and Hoxa1 in early patterning events in r4. Our genetic analysis shows that individual members of the vertebrate labial-related genes have multiple roles in different steps governing segmental processes in the developing hindbrain.
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K Niederreither, J Vermot, B Schuhbaur, P Chambon, and P Dolle Retinoic acid synthesis and hindbrain patterning in the mouse embryo Development, January 1, 2000; 127(1): 75 - 85. [Abstract] [PDF]
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I Pata, M Studer, J. van Doorninck, J Briscoe, S Kuuse, J. Engel, F Grosveld, and A Karis The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4 Development, January 12, 1999; 126(23): 5523 - 5531. [Abstract] [PDF]
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A Locascio, F Aniello, A Amoroso, M Manzanares, R Krumlauf, and M Branno Patterning the ascidian nervous system: structure, expression and transgenic analysis of the CiHox3 gene Development, January 11, 1999; 126(21): 4737 - 4748. [Abstract] [PDF]
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J. Barrow and M. Capecchi Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants Development, January 11, 1999; 126(22): 5011 - 5026. [Abstract] [PDF]
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M Rossel and M. Capecchi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development Development, January 11, 1999; 126(22): 5027 - 5040. [Abstract] [PDF]
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M Manzanares, S Cordes, L Ariza-McNaughton, V Sadl, K Maruthainar, G Barsh, and R Krumlauf Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes Development, January 2, 1999; 126(4): 759 - 769. [Abstract] [PDF]
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J. Chen and H. E. Ruley An Enhancer Element in the EphA2 (Eck) Gene Sufficient for Rhombomere-specific Expression Is Activated by HOXA1 and HOXB1 Homeobox Proteins J. Biol. Chem., September 18, 1998; 273(38): 24670 - 24675. [Abstract] [Full Text] [PDF]
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F Helmbacher, C Pujades, C Desmarquet, M Frain, F. Rijli, P Chambon, and P Charnay Hoxa1 and Krox-20 synergize to control the development of rhombomere 3 Development, January 12, 1998; 125(23): 4739 - 4748. [Abstract] [PDF]
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A Gavalas, M Studer, A Lumsden, F. Rijli, R Krumlauf, and P Chambon Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch Development, January 3, 1998; 125(6): 1123 - 1136. [Abstract] [PDF]
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G. Di Rocco, A. Gavalas, H. Popperl, R. Krumlauf, F. Mavilio, and V. Zappavigna The Recruitment of SOX/OCT Complexes and the Differential Activity of HOXA1 and HOXB1 Modulate the Hoxb1 Auto-regulatory Enhancer Function J. Biol. Chem., June 1, 2001; 276(23): 20506 - 20515. [Abstract] [Full Text] [PDF]
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