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Development, Vol 125, Issue 8 1541-1552, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
MJ Hardman, P Sisi, DN Banbury and C Byrne
School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.
Skin barrier function is conferred by the outer layer of epidermis, the stratum corneum, and is essential for terrestrial life. Quantitative trans-epidermal water loss assays show that barrier forms late in embryogenesis, permitting the foetus to survive a terrestrial environment at birth. Using qualitative in situ assays for skin permeability, we show that barrier forms in a patterned manner late in mouse gestation. Barrier forms at specific epidermal sites, then spreads around the embryo as a moving front. The moving front of permeability change is accompanied by multiple changes in the outer, stratum corneum-precursor cells. We use the permeability assays to show that final stages of cornified envelope assembly are coordinated with initial stages of barrier formation. Hence the whole-mount permeability assays record developmental acquisition of a known, essential component of the adult barrier. We demonstrate the authenticity of the whole-mount assays after maternal glucocorticoid therapy (known to accelerate barrier formation) and in additional species including the rat where barrier formation is well characterized by TEWL assay (Aszterbaum, M., Menon, G. K., Feingold, K. R. and Williams, M. L. Pediatr. Res. 31, 308-317). The demonstration of patterned barrier formation in other species suggests patterned change as the universal mode of embryonic barrier acquisition. These results highlight the importance of patterning as a mode of epidermal maturation during development.
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|
|
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|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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 |
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|
|
|
|
|
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|
|
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|
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|
|
|
|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C. Berry Keeping it together QJM, November 1, 2002; 95(11): 765 - 766. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Doering, H. Brade, and K. Sandhoff Sphingolipid metabolism during epidermal barrier development in mice J. Lipid Res., October 1, 2002; 43(10): 1727 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
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K. Turksen and T.-C. Troy Permeability barrier dysfunction in transgenic mice overexpressing claudin 6 Development, January 4, 2002; 129(7): 1775 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Hoath and V. Narendran Development of the Epidermal Barrier NeoReviews, December 1, 2001; 2(12): e269 - 281. [Full Text] [PDF]
|
|
|
|
|
|
D. Marshall, M. J. Hardman, K. M. Nield, and C. Byrne Differentially expressed late constituents of the epidermal cornified envelope PNAS, November 6, 2001; 98(23): 13031 - 13036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maatta, T. DiColandrea, K. Groot, and F. M. Watt Gene Targeting of Envoplakin, a Cytoskeletal Linker Protein and Precursor of the Epidermal Cornified Envelope Mol. Cell. Biol., October 15, 2001; 21(20): 7047 - 7053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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L. Michalik, B. Desvergne, N. S. Tan, S. Basu-Modak, P. Escher, J. Rieusset, J. M. Peters, G. Kaya, F. J. Gonzalez, J. Zakany, et al. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR){alpha} and PPAR{beta} mutant mice J. Cell Biol., August 20, 2001; 154(4): 799 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Merrill, U. Gat, R. DasGupta, and E. Fuchs Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin Genes & Dev., July 1, 2001; 15(13): 1688 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
B. Peters, J. Kirfel, H. Bussow, M. Vidal, and T. M. Magin Complete Cytolysis and Neonatal Lethality in Keratin 5 Knockout Mice Reveal Its Fundamental Role in Skin Integrity and in Epidermolysis Bullosa Simplex Mol. Biol. Cell, June 1, 2001; 12(6): 1775 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Li, H Chiba, X Warot, N Messaddeq, C Gerard, P Chambon, and D Metzger RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations Development, January 3, 2001; 128(5): 675 - 688. [Abstract] [PDF]
|
|
|
|
|
|
P. J. Koch, P. A. de Viragh, E. Scharer, D. Bundman, M. A. Longley, J. Bickenbach, Y. Kawachi, Y. Suga, Z. Zhou, M. Huber, et al. Lessons from Loricrin-Deficient Mice: Compensatory Mechanisms Maintaining Skin Barrier Function in the Absence of a Major Cornified Envelope Protein J. Cell Biol., October 16, 2000; 151(2): 389 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Brouard, M Casado, S Djelidi, Y Barrandon, and N Farman Epithelial sodium channel in human epidermal keratinocytes: expression of its subunits and relation to sodium transport and differentiation J. Cell Sci., January 10, 1999; 112(19): 3343 - 3352. [Abstract] [PDF]
|
|
|
|
|
|
M. Chidgey, C. Brakebusch, E. Gustafsson, A. Cruchley, C. Hail, S. Kirk, A. Merritt, A. North, C. Tselepis, J. Hewitt, et al. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation J. Cell Biol., November 26, 2001; 155(5): 821 - 832. [Abstract] [Full Text] [PDF]
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