|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 1 1-11, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
H Tabara, RJ Hill, CC Mello, JR Priess and Y Kohara
Department of Genetics, Graduate University of Advanced Studies and Gene Network Lab, National Institute of Genetics, Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Mishima 411, Japan.
Germ cells arise during early C. elegans embryogenesis from an invariant sequence of asymmetric divisions that separate germ cell precursors from somatic precursors. We show that maternal-effect lethal mutations in the gene pos-1 cause germ cell precursors to inappropriately adopt somatic cell fates. During early embryogenesis, pos-1 mRNA and POS-1 protein are present predominantly in the germ precursors. POS-1 is a novel protein with two copies of a CCCH finger motif previously described in the germline proteins PIE-1 and MEX-1 in C. elegans, and in the mammalian TIS11/Nup475/TTP protein. However, mutations in pos-1 cause several defects in the development of the germline blastomeres that are distinct from those caused by mutations in pie-1 or mex-1. The earliest defect detected in pos-1 mutants is the failure to express APX-1 protein from maternally provided apx-1 mRNA, suggesting that POS-1 may have an important role in regulating the expression of maternal mRNAs in germline blastomeres.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Henderson, E. Cronland, S. Dunkelbarger, V. Contreras, S. Strome, and B. D. Keiper A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm J. Cell Sci., May 15, 2009; 122(10): 1529 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Farley, J. M. Pagano, and S. P. Ryder RNA target specificity of the embryonic cell fate determinant POS-1 RNA, December 1, 2008; 14(12): 2685 - 2697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Noble, B. L. Allen, L. K. Goh, K. Nordick, and T. C. Evans Maternal mRNAs are regulated by diverse P body-related mRNP granules during early Caenorhabditis elegans development J. Cell Biol., August 11, 2008; 182(3): 559 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Boag, A. Atalay, S. Robida, V. Reinke, and T. K. Blackwell Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis J. Cell Biol., August 11, 2008; 182(3): 543 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jadhav, M. Rana, and K. Subramaniam Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells Development, May 15, 2008; 135(10): 1803 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Rocheleau, K. Cullison, K. Huang, Y. Bernstein, A. C. Spilker, and M. V. Sundaram The Caenorhabditis elegans ekl (Enhancer of ksr-1 Lethality) Genes Include Putative Components of a Germline Small RNA Pathway Genetics, March 1, 2008; 178(3): 1431 - 1443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishi, E. Rogers, S. M. Robertson, and R. Lin Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6 Development, February 15, 2008; 135(4): 687 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Pagano, B. M. Farley, L. M. McCoig, and S. P. Ryder Molecular Basis of RNA Recognition by the Embryonic Polarity Determinant MEX-5 J. Biol. Chem., March 23, 2007; 282(12): 8883 - 8894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Paterou, P. Walrad, P. Craddy, K. Fenn, and K. Matthews Identification and Stage-specific Association with the Translational Apparatus of TbZFP3, a CCCH Protein That Promotes Trypanosome Life-cycle Development J. Biol. Chem., December 22, 2006; 281(51): 39002 - 39013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Tenlen, J. A. Schisa, S. J. Diede, and B. D. Page Reduced Dosage of pos-1 Suppresses Mex Mutants and Reveals Complex Interactions Among CCCH Zinc-Finger Proteins During Caenorhabditis elegans Embryogenesis Genetics, December 1, 2006; 174(4): 1933 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Kritikou, S. Milstein, P.-O. Vidalain, G. Lettre, E. Bogan, K. Doukoumetzidis, P. Gray, T. G. Chappell, M. Vidal, and M. O. Hengartner C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes & Dev., August 15, 2006; 20(16): 2279 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chi and V. Reinke Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB) Development, August 15, 2006; 133(16): 3147 - 3157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Kong, M. Li, W. Yang, W. Xu, and Y. Xue A Novel Nuclear-Localized CCCH-Type Zinc Finger Protein, OsDOS, Is Involved in Delaying Leaf Senescence in Rice Plant Physiology, August 1, 2006; 141(4): 1376 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shimada, H. Yokosawa, and H. Kawahara OMA-1 is a P granules-associated protein that is required for germline specification in Caenorhabditis elegans embryos Genes Cells, April 1, 2006; 11(4): 383 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bowerman and T. Kurz Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during early C. elegans embryogenesis Development, March 1, 2006; 133(5): 773 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Blackshear, R. S. Phillips, S. Ghosh, S. V.B. Ramos, E. K. Richfield, and W. S. Lai Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins Biol Reprod, August 1, 2005; 73(2): 297 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Zgurski, R. Sharma, D. A. Bolokoski, and E. A. Schultz Asymmetric Auxin Response Precedes Asymmetric Growth and Differentiation of asymmetric leaf1 and asymmetric leaf2 Arabidopsis Leaves PLANT CELL, January 1, 2005; 17(1): 77 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Grigorenko, Y. K. Moliaka, M. C. Soto, C. C. Mello, and E. I. Rogaev The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins PNAS, October 12, 2004; 101(41): 14955 - 14960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. V. Ramos, D. J. Stumpo, E. A. Kennington, R. S. Phillips, C. B. Bock, F. Ribeiro-Neto, and P. J. Blackshear The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development Development, October 1, 2004; 131(19): 4883 - 4893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, J. M. Foster, S. Kumar, M. Fougere, and C. K. S. Carlow Cofactor-independent Phosphoglycerate Mutase Has an Essential Role in Caenorhabditis elegans and Is Conserved in Parasitic Nematodes J. Biol. Chem., August 27, 2004; 279(35): 37185 - 37190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Tchen, M. Brook, J. Saklatvala, and A. R. Clark The Stability of Tristetraprolin mRNA Is Regulated by Mitogen-activated Protein Kinase p38 and by Tristetraprolin Itself J. Biol. Chem., July 30, 2004; 279(31): 32393 - 32400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kawasaki, A. Amiri, Y. Fan, N. Meyer, S. Dunkelbarger, T. Motohashi, T. Karashima, O. Bossinger, and S. Strome The PGL Family Proteins Associate With Germ Granules and Function Redundantly in Caenorhabditis elegans Germline Development Genetics, June 1, 2004; 167(2): 645 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Andachi Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis Genes Cells, April 1, 2004; 9(4): 331 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Ogura, N. Kishimoto, S. Mitani, K. Gengyo-Ando, and Y. Kohara Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans Development, June 1, 2003; 130(11): 2495 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tacahashi, S. Helmling, and C. L. Moore Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor Nucleic Acids Res., March 15, 2003; 31(6): 1744 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Lee and B. Goldstein Mechanisms of cell positioning during C. elegans gastrulation Development, March 2, 2003; 130(2): 307 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Hwang, A. Choi, and I-C. Ho Transcriptional Regulation of GATA-3 by an Intronic Regulatory Region and Fetal Liver Zinc Finger Protein 1 J. Immunol., July 1, 2002; 169(1): 248 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Johnson, J. R. Stehn, M. B. Yaffe, and T. K. Blackwell Cytoplasmic Localization of Tristetraprolin Involves 14-3-3-dependent and -independent Mechanisms J. Biol. Chem., May 10, 2002; 277(20): 18029 - 18036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Huang, D. E. Mootz, A. J. M. Walhout, M. Vidal, and C. P. Hunter MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans Development, January 2, 2002; 129(3): 747 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-E. Gomes, S. E. Encalada, K. A. Swan, C. A. Shelton, J. C. Carter, and B. Bowerman The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos Development, November 1, 2001; 128(21): 4301 - 4314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Amiri, B. D. Keiper, I. Kawasaki, Y. Fan, Y. Kohara, R. E. Rhoads, and S. Strome An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans Development, October 15, 2001; 128(20): 3899 - 3912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hanazawa, M. Mochii, N. Ueno, Y. Kohara, and Y. Iino Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans PNAS, July 5, 2001; (2001) 141004698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tenenhaus, K. Subramaniam, M. A. Dunn, and G. Seydoux PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans Genes & Dev., April 15, 2001; 15(8): 1031 - 1040. [Abstract] [Full Text]
|
|
|
|
|
|
J. Schisa, J. Pitt, and J. Priess Analysis of RNA associated with P granules in germ cells of C. elegans adults Development, January 4, 2001; 128(8): 1287 - 1298. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Grishok, H. Tabara, and C. C. Mello Genetic Requirements for Inheritance of RNAi in C. elegans Science, March 31, 2000; 287(5462): 2494 - 2497. [Abstract] [Full Text]
|
|
|
|
|
|
L. Berkowitz and S Strome MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells Development, January 10, 2000; 127(20): 4419 - 4431. [Abstract] [PDF]
|
|
|
|
|
|
K. Kuznicki, P. Smith, W. Leung-Chiu, A. Estevez, H. Scott, and K. Bennett Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans Development, January 7, 2000; 127(13): 2907 - 2916. [Abstract] [PDF]
|
|
|
|
|
|
C. Batchelder, M. A. Dunn, B. Choy, Y. Suh, C. Cassie, E. Y. Shim, T. H. Shin, C. Mello, G. Seydoux, and T. K. Blackwell Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1 Genes & Dev., January 15, 1999; 13(2): 202 - 212. [Abstract] [Full Text]
|
|
|
|
|
|
K. Siegfried, Y Eshed, S. Baum, D Otsuga, G. Drews, and J. Bowman Members of the YABBY gene family specify abaxial cell fate in Arabidopsis Development, January 9, 1999; 126(18): 4117 - 4128. [Abstract] [PDF]
|
|
|
|
|
|
G Seydoux and S Strome Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells Development, January 8, 1999; 126(15): 3275 - 3283. [Abstract] [PDF]
|
|
|
|
|
|
M. Hanazawa, M. Mochii, N. Ueno, Y. Kohara, and Y. Iino Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans PNAS, July 17, 2001; 98(15): 8686 - 8691. [Abstract] [Full Text] [PDF]
|
|
