Development, Vol 126, Issue 10 2033-2044, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Eph receptors and ephrins: effectors of morphogenesis

N Holder and R Klein
Department of Anatomy and Developmental Biology, University College, Gower Street, London, WC1 6BT, UK. Klein@embl-heidelberg.de

Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis. We review the role of Eph and ephrin signalling in the formation of segmented structures, in the control of axon guidance and cell migration and in the development of the vasculature. We address the question of how the specificity of response is achieved and discuss the specificity of ephrin-Eph interactions and the significance of structural domains in Eph receptors.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. R. Swift and B. M. Weinstein Arterial-Venous Specification During Development Circ. Res., March 13, 2009; 104(5): 576 - 588. [Abstract] [Full Text] [PDF]

				Y. Kawakami, Y. Uchiyama, C. Rodriguez Esteban, T. Inenaga, N. Koyano-Nakagawa, H. Kawakami, M. Marti, M. Kmita, P. Monaghan-Nichols, R. Nishinakamura, et al. Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities Development, February 15, 2009; 136(4): 585 - 594. [Abstract] [Full Text] [PDF]

				H. L. Holen, M. Shadidi, K. Narvhus, O. Kjosnes, A. Tierens, and H.-C. Aasheim Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis J. Leukoc. Biol., October 1, 2008; 84(4): 1183 - 1191. [Abstract] [Full Text] [PDF]

				E. J. Yavrouian, U. K. Sinha, D. H. Rice, M. T. Salam, P. S. Gill, and R. Masood The Significance of EphB4 and EphrinB2 Expression and Survival in Head and Neck Squamous Cell Carcinoma Arch Otolaryngol Head Neck Surg, September 1, 2008; 134(9): 985 - 991. [Abstract] [Full Text] [PDF]

				T. Yamashita, K. Ohneda, M. Nagano, C. Miyoshi, N. Kaneko, Y. Miwa, M. Yamamoto, O. Ohneda, and Y. Fujii-Kuriyama Hypoxia-inducible Transcription Factor-2{alpha} in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1 J. Biol. Chem., July 4, 2008; 283(27): 18926 - 18936. [Abstract] [Full Text] [PDF]

				R Holm, S Knopp, Z Suo, C Trope, and J M Nesland Expression of EphA2 and EphrinA-1 in vulvar carcinomas and its relation to prognosis J. Clin. Pathol., October 1, 2007; 60(10): 1086 - 1091. [Abstract] [Full Text] [PDF]

				E. C. Bolton, A. Y. So, C. Chaivorapol, C. M. Haqq, H. Li, and K. R. Yamamoto Cell- and gene-specific regulation of primary target genes by the androgen receptor Genes & Dev., August 15, 2007; 21(16): 2005 - 2017. [Abstract] [Full Text] [PDF]

				S. Alam, J Fujimoto, I Jahan, E Sato, and T Tamaya Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers Ann. Onc., March 1, 2007; 18(3): 485 - 490. [Abstract] [Full Text] [PDF]

				F. Liu, P. J. Park, W. Lai, E. Maher, A. Chakravarti, L. Durso, X. Jiang, Y. Yu, A. Brosius, M. Thomas, et al. A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma Cancer Res., November 15, 2006; 66(22): 10815 - 10823. [Abstract] [Full Text] [PDF]

				U. K. Sinha, K. Mazhar, S. B. Chinn, V. K. Dhillon, L. Liu, R. Masood, D. H. Rice, and P. S. Gill The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg, October 1, 2006; 132(10): 1053 - 1059. [Abstract] [Full Text] [PDF]

				H. Guo, H. Miao, L. Gerber, J. Singh, M. F. Denning, A. C. Gilliam, and B. Wang Disruption of EphA2 Receptor Tyrosine Kinase Leads to Increased Susceptibility to Carcinogenesis in Mouse Skin. Cancer Res., July 15, 2006; 66(14): 7050 - 7058. [Abstract] [Full Text] [PDF]

				S. R. Kumar, J. Singh, G. Xia, V. Krasnoperov, L. Hassanieh, E. J. Ley, J. Scehnet, N. G. Kumar, D. Hawes, M. F. Press, et al. Receptor Tyrosine Kinase EphB4 Is a Survival Factor in Breast Cancer Am. J. Pathol., July 1, 2006; 169(1): 279 - 293. [Abstract] [Full Text] [PDF]

				M. Takano-Maruyama, K. Hase, H. Fukamachi, Y. Kato, H. Koseki, and H. Ohno Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G163 - G170. [Abstract] [Full Text] [PDF]

				S. Abraham, D. W. Knapp, L. Cheng, P. W. Snyder, S. K. Mittal, D. S. Bangari, M. Kinch, L. Wu, J. Dhariwal, and S. I. Mohammed Expression of EphA2 and Ephrin A-1 in Carcinoma of the Urinary Bladder Clin. Cancer Res., January 15, 2006; 12(2): 353 - 360. [Abstract] [Full Text] [PDF]

				M. Parri, F. Buricchi, M. L. Taddei, E. Giannoni, G. Raugei, G. Ramponi, and P. Chiarugi EphrinA1 Repulsive Response Is Regulated by an EphA2 Tyrosine Phosphatase J. Biol. Chem., October 7, 2005; 280(40): 34008 - 34018. [Abstract] [Full Text] [PDF]

				H. Matsuoka, H. Obama, M. L. Kelly, T. Matsui, and M. Nakamoto Biphasic Functions of the Kinase-defective Ephb6 Receptor in Cell Adhesion and Migration J. Biol. Chem., August 12, 2005; 280(32): 29355 - 29363. [Abstract] [Full Text] [PDF]

				G. Xia, S. R. Kumar, R. Masood, M. Koss, C. Templeman, D. Quinn, S. Zhu, R. Reddy, V. Krasnoperov, and P. S. Gill Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance Clin. Cancer Res., June 15, 2005; 11(12): 4305 - 4315. [Abstract] [Full Text] [PDF]

				G. Xia, S. R. Kumar, R. Masood, S. Zhu, R. Reddy, V. Krasnoperov, D. I. Quinn, S. M. Henshall, R. L. Sutherland, J. K. Pinski, et al. EphB4 Expression and Biological Significance in Prostate Cancer Cancer Res., June 1, 2005; 65(11): 4623 - 4632. [Abstract] [Full Text] [PDF]

				X. Ran and J. Song Structural Insight into the Binding Diversity between the Tyr-phosphorylated Human EphrinBs and Nck2 SH2 Domain J. Biol. Chem., May 13, 2005; 280(19): 19205 - 19212. [Abstract] [Full Text] [PDF]

				H.-C. Aasheim, J. Delabie, and E. F. Finne Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2 Blood, April 1, 2005; 105(7): 2869 - 2876. [Abstract] [Full Text] [PDF]

				S. R. F. Twigg, R. Kan, C. Babbs, E. G. Bochukova, S. P. Robertson, S. A. Wall, G. M. Morriss-Kay, and A. O. M. Wilkie Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome PNAS, June 8, 2004; 101(23): 8652 - 8657. [Abstract] [Full Text] [PDF]

				B. R. Shepherd, H. Y.S. Chen, C. M. Smith, G. Gruionu, S. K. Williams, and J. B. Hoying Rapid Perfusion and Network Remodeling in a Microvascular Construct After Implantation Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 898 - 904. [Abstract] [Full Text]

				B. Fuss, F. Josten, M. Feix, and M. Hoch Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila Development, April 1, 2004; 131(7): 1587 - 1595. [Abstract] [Full Text] [PDF]

				S. H. Wimmer-Kleikamp, P. W. Janes, A. Squire, P. I.H. Bastiaens, and M. Lackmann Recruitment of Eph receptors into signaling clusters does not require ephrin contact J. Cell Biol., March 1, 2004; 164(5): 661 - 666. [Abstract] [Full Text] [PDF]

				W. Mao, E. Luis, S. Ross, J. Silva, C. Tan, C. Crowley, C. Chui, G. Franz, P. Senter, H. Koeppen, et al. EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer Cancer Res., February 1, 2004; 64(3): 781 - 788. [Abstract] [Full Text] [PDF]

				J. G. Wohlfahrt, C. Karagiannidis, S. Kunzmann, M. M. Epstein, W. Kempf, K. Blaser, and C. B. Schmidt-Weber Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells J. Immunol., January 15, 2004; 172(2): 843 - 850. [Abstract] [Full Text] [PDF]

				M. Kaneko and A. Nighorn Interaxonal Eph-Ephrin Signaling May Mediate Sorting of Olfactory Sensory Axons in Manduca sexta J. Neurosci., December 17, 2003; 23(37): 11523 - 11538. [Abstract] [Full Text] [PDF]

				P. M. S. Alves, O. Faure, S. Graff-Dubois, D.-A. Gross, S. Cornet, S. Chouaib, I. Miconnet, F. A. Lemonnier, and K. Kosmatopoulos EphA2 as Target of Anticancer Immunotherapy: Identification of HLA-A*0201-Restricted Epitopes Cancer Res., December 1, 2003; 63(23): 8476 - 8480. [Abstract] [Full Text] [PDF]

				A. P. SOMLYO and A. V. SOMLYO Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase Physiol Rev, October 1, 2003; 83(4): 1325 - 1358. [Abstract] [Full Text] [PDF]

				H. Miao, C. H. Nickel, L. G. Cantley, L. A. Bruggeman, L. N. Bennardo, and B. Wang EphA kinase activation regulates HGF-induced epithelial branching morphogenesis J. Cell Biol., September 29, 2003; 162(7): 1281 - 1292. [Abstract] [Full Text] [PDF]

				M. Egawa, S. Yoshioka, T. Higuchi, Y. Sato, K. Tatsumi, H. Fujiwara, and S. Fujii Ephrin B1 Is Expressed on Human Luteinizing Granulosa Cells in Corpora Lutea of the Early Luteal Phase: The Possible Involvement of the B Class Eph-Ephrin System during Corpus Luteum Formation J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4384 - 4392. [Abstract] [Full Text] [PDF]

				J. Song Tyrosine Phosphorylation of the Well Packed EphrinB Cytoplasmic {beta}-Hairpin for Reverse Signaling: STRUCTURAL CONSEQUENCES AND BINDING PROPERTIES J. Biol. Chem., June 27, 2003; 278(27): 24714 - 24720. [Abstract] [Full Text] [PDF]

				D. W. Houston and C. Wylie The Xenopus LIM-homeodomain protein Xlim5 regulates the differential adhesion properties of early ectoderm cells Development, June 15, 2003; 130(12): 2695 - 2704. [Abstract] [Full Text] [PDF]

				A. Palmer and R. Klein Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function Genes & Dev., June 15, 2003; 17(12): 1429 - 1450. [Full Text] [PDF]

				C. Deroanne, V. Vouret-Craviari, B. Wang, and J. Pouyssegur EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway J. Cell Sci., April 1, 2003; 116(7): 1367 - 1376. [Abstract] [Full Text] [PDF]

				A. Sakakibara, Y. Ohba, K. Kurokawa, M. Matsuda, and S. Hattori Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation J. Cell Sci., March 14, 2003; 115(24): 4915 - 4924. [Abstract] [Full Text] [PDF]

				T. Bossing and A. H. Brand Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS Development, March 11, 2003; 129(18): 4205 - 4218. [Abstract] [Full Text] [PDF]

				J. Ghislain, C. Desmarquet-Trin-Dinh, P. Gilardi-Hebenstreit, P. Charnay, and M. Frain Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control Development, March 1, 2003; 130(5): 941 - 953. [Abstract] [Full Text] [PDF]

				A. Sakakibara, S. Hattori, S. Nakamura, and T. Katagiri A Novel Hematopoietic Adaptor Protein, Chat-H, Positively Regulates T Cell Receptor-mediated Interleukin-2 Production by Jurkat Cells J. Biol. Chem., February 14, 2003; 278(8): 6012 - 6017. [Abstract] [Full Text] [PDF]

				G. Berclaz, E. Karamitopoulou, L. Mazzucchelli, V. Rohrbach, E. Dreher, A. Ziemiecki, and A.-C. Andres Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma Ann. Onc., February 1, 2003; 14(2): 220 - 226. [Abstract] [Full Text] [PDF]

				K. Hamada, Y. Oike, Y. Ito, H. Maekawa, K. Miyata, T. Shimomura, and T. Suda Distinct Roles of Ephrin-B2 Forward and EphB4 Reverse Signaling in Endothelial Cells Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 190 - 197. [Abstract] [Full Text] [PDF]

				H. Fujiwara, S. Yoshioka, K. Tatsumi, K. Kosaka, Y. Satoh, Y. Nishioka, M. Egawa, T. Higuchi, and S. Fujii Human Endometrial Epithelial Cells Express Ephrin A1: Possible Interaction between Human Blastocysts and Endometrium via Eph-Ephrin System J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5801 - 5807. [Abstract] [Full Text] [PDF]

				K.-I. Nagashima, A. Endo, H. Ogita, A. Kawana, A. Yamagishi, A. Kitabatake, M. Matsuda, and N. Mochizuki Adaptor Protein Crk Is Required for Ephrin-B1-induced Membrane Ruffling and Focal Complex Assembly of Human Aortic Endothelial Cells Mol. Biol. Cell, December 1, 2002; 13(12): 4231 - 4242. [Abstract] [Full Text] [PDF]

				N. Cheng, D. M. Brantley, H. Liu, Q. Lin, M. Enriquez, N. Gale, G. Yancopoulos, D. P. Cerretti, T. O. Daniel, and J. Chen Blockade of EphA Receptor Tyrosine Kinase Activation Inhibits Vascular Endothelial Cell Growth Factor-Induced Angiogenesis Mol. Cancer Res., November 1, 2002; 1(1): 2 - 11. [Abstract] [Full Text] [PDF]

				X. Qu, H. Wei, Y. Zhai, H. Que, Q. Chen, F. Tang, Y. Wu, G. Xing, Y. Zhu, S. Liu, et al. Identification, Characterization, and Functional Study of the Two Novel Human Members of the Semaphorin Gene Family J. Biol. Chem., September 13, 2002; 277(38): 35574 - 35585. [Abstract] [Full Text] [PDF]

				C. R. Coffman, R. C. Strohm, F. D. Oakley, Y. Yamada, D. Przychodzin, and R. E. Boswell Identification of X-Linked Genes Required for Migration and Programmed Cell Death of Drosophila melanogaster Germ Cells Genetics, September 1, 2002; 162(1): 273 - 284. [Abstract] [Full Text] [PDF]

				Y. Sato, K. Yasuda, and Y. Takahashi Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation Development, August 1, 2002; 129(15): 3633 - 3644. [Abstract] [Full Text] [PDF]

				Y. Oike, Y. Ito, K. Hamada, X.-Q. Zhang, K. Miyata, F. Arai, T. Inada, K. Araki, N. Nakagata, M. Takeya, et al. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells Blood, July 30, 2002; 100(4): 1326 - 1333. [Abstract] [Full Text] [PDF]

				J. J. Munoz, L. M. Alonso-C., R. Sacedon, T. Crompton, A. Vicente, E. Jimenez, A. Varas, and A. G. Zapata Expression and Function of the Eph A Receptors and Their Ligands Ephrins A in the Rat Thymus J. Immunol., July 1, 2002; 169(1): 177 - 184. [Abstract] [Full Text] [PDF]

				E. Trivier and T. S. Ganesan RYK, a Catalytically Inactive Receptor Tyrosine Kinase, Associates with EphB2 and EphB3 but Does Not Interact with AF-6 J. Biol. Chem., June 14, 2002; 277(25): 23037 - 23043. [Abstract] [Full Text] [PDF]

				C. Gu, B. J. Limberg, G. B. Whitaker, B. Perman, D. J. Leahy, J. S. Rosenbaum, D. D. Ginty, and A. L. Kolodkin Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165 J. Biol. Chem., May 10, 2002; 277(20): 18069 - 18076. [Abstract] [Full Text] [PDF]

				N. Baumer, T. Marquardt, A. Stoykova, R. Ashery-Padan, K. Chowdhury, and P. Gruss Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle Development, January 10, 2002; 129(19): 4535 - 4545. [Abstract] [Full Text] [PDF]

				U. Huynh-Do, C. Vindis, H. Liu, D. P. Cerretti, J. T. McGrew, M. Enriquez, J. Chen, and T. O. Daniel Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis J. Cell Sci., January 8, 2002; 115(15): 3073 - 3081. [Abstract] [Full Text] [PDF]

				I. D. Lawrenson, S. H. Wimmer-Kleikamp, P. Lock, S. M. Schoenwaelder, M. Down, A. W. Boyd, P. F. Alewood, and M. Lackmann Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling J. Cell Sci., January 3, 2002; 115(5): 1059 - 1072. [Abstract] [Full Text] [PDF]

				J. P. Golding, M. Dixon, and M. Gassmann Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick Development, January 3, 2002; 129(5): 1095 - 1105. [Abstract] [Full Text] [PDF]

				E. I. Rugarli, E. Di Schiavi, M. A. Hilliard, S. Arbucci, C. Ghezzi, A. Facciolli, G. Coppola, A. Ballabio, and P. Bazzicalupo The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching Development, January 3, 2002; 129(5): 1283 - 1294. [Abstract] [Full Text] [PDF]

				N. Munarini, R. Jager, S. Abderhalden, G. Zuercher, V. Rohrbach, S. Loercher, B. Pfanner-Meyer, A.-C. Andres, and A. Ziemiecki Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase J. Cell Sci., January 1, 2002; 115(1): 25 - 37. [Abstract] [Full Text] [PDF]

				S. J. Fashena, M. B. Einarson, G. M. O'Neill, C. Patriotis, and E. A. Golemis Dissection of HEF1-dependent functions in motility and transcriptional regulation J. Cell Sci., January 1, 2002; 115(1): 99 - 111. [Abstract] [Full Text] [PDF]

				R. Imondi and Z. Kaprielian Commissural axon pathfinding on the contralateral side of the floor plate: a role for B-class ephrins in specifying the dorsoventral position of longitudinally projecting commissural axons Development, December 1, 2001; 128(23): 4859 - 4871. [Abstract] [Full Text] [PDF]

				T. Takahashi, K. Takahashi, S. Gerety, H. Wang, D. J. Anderson, and T. O. Daniel Temporally Compartmentalized Expression of Ephrin-B2 during Renal Glomerular Development J. Am. Soc. Nephrol., December 1, 2001; 12(12): 2673 - 2682. [Abstract] [Full Text] [PDF]

				G. Jeffery Architecture of the Optic Chiasm and the Mechanisms That Sculpt Its Development Physiol Rev, October 1, 2001; 81(4): 1393 - 1414. [Abstract] [Full Text] [PDF]

				T. Kume, H. Jiang, J. M. Topczewska, and B. L.M. Hogan The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis Genes & Dev., September 15, 2001; 15(18): 2470 - 2482. [Abstract] [Full Text] [PDF]

				J. M. Topczewska, J. Topczewski, A. Shostak, T. Kume, L. Solnica-Krezel, and B. L.M. Hogan The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish Genes & Dev., September 15, 2001; 15(18): 2483 - 2493. [Abstract] [Full Text] [PDF]

				X.-Q. Zhang, N. Takakura, Y. Oike, T. Inada, N. W. Gale, G. D. Yancopoulos, and T. Suda Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2+ endothelial cells Blood, August 15, 2001; 98(4): 1028 - 1037. [Abstract] [Full Text] [PDF]

				I. Stuckmann, A. Weigmann, A. Shevchenko, M. Mann, and W. B. Huttner Ephrin B1 Is Expressed on Neuroepithelial Cells in Correlation with Neocortical Neurogenesis J. Neurosci., April 15, 2001; 21(8): 2726 - 2737. [Abstract] [Full Text] [PDF]

				J.-h. Chen, L. Wen, S. Dupuis, J. Y. Wu, and Y. Rao The N-terminal Leucine-Rich Regions in Slit Are Sufficient To Repel Olfactory Bulb Axons and Subventricular Zone Neurons J. Neurosci., March 1, 2001; 21(5): 1548 - 1556. [Abstract] [Full Text] [PDF]

				B Knoll, K Zarbalis, W Wurst, and U Drescher A role for the EphA family in the topographic targeting of vomeronasal axons Development, January 3, 2001; 128(6): 895 - 906. [Abstract] [PDF]

				J Cooke, C Moens, L Roth, L Durbin, K Shiomi, C Brennan, C Kimmel, S Wilson, and N Holder Eph signalling functions downstream of Val to regulate cell sorting and boundary formation in the caudal hindbrain Development, January 2, 2001; 128(4): 571 - 580. [Abstract] [PDF]

				M. Sachs, H. Brohmann, D. Zechner, T. Muller, J. Hulsken, I. Walther, U. Schaeper, C. Birchmeier, and W. Birchmeier Essential Role of Gab1 for Signaling by the c-Met Receptor In Vivo J. Cell Biol., September 18, 2000; 150(6): 1375 - 1384. [Abstract] [Full Text] [PDF]

				T. Nakashiba, T. Ikeda, S. Nishimura, K. Tashiro, T. Honjo, J. G. Culotti, and S. Itohara Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins J. Neurosci., September 1, 2000; 20(17): 6540 - 6550. [Abstract] [Full Text] [PDF]

				T. Pawson and P. Nash Protein-protein interactions define specificity in signal transduction Genes & Dev., May 1, 2000; 14(9): 1027 - 1047. [Full Text]

				C. Myers, A. Charboneau, and N. Boudreau Homeobox B3 Promotes Capillary Morphogenesis and Angiogenesis J. Cell Biol., January 24, 2000; 148(2): 343 - 352. [Abstract] [Full Text] [PDF]

				H Paradis and R. Gendron LIF transduces contradictory signals on capillary outgrowth through induction of stat3 and (P41/43)MAP kinase J. Cell Sci., January 12, 2000; 113(23): 4331 - 4339. [Abstract] [PDF]

				C. Miller, T. Schilling, K Lee, J Parker, and C. Kimmel sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development Development, January 9, 2000; 127(17): 3815 - 3828. [Abstract] [PDF]

				S Orsulic and R Kemler Expression of Eph receptors and ephrins is differentially regulated by E-cadherin J. Cell Sci., January 5, 2000; 113(10): 1793 - 1802. [Abstract] [PDF]

				R Imondi, C Wideman, and Z Kaprielian Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons Development, January 4, 2000; 127(7): 1397 - 1410. [Abstract] [PDF]

				M Salminen, B. Meyer, E Bober, and P Gruss Netrin 1 is required for semicircular canal formation in the mouse inner ear Development, January 1, 2000; 127(1): 13 - 22. [Abstract] [PDF]

				P. Helbling, D. Saulnier, and A. Brandli The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis Development, January 1, 2000; 127(2): 269 - 278. [Abstract] [PDF]

				J. Zallen, S. Kirch, and C. Bargmann Genes required for axon pathfinding and extension in the C. elegans nerve ring Development, January 8, 1999; 126(16): 3679 - 3692. [Abstract] [PDF]

				A. Klostermann, B. Lutz, F. Gertler, and C. Behl The Orthologous Human and Murine Semaphorin 6A-1 Proteins (SEMA6A-1/Sema6A-1) Bind to the Enabled/Vasodilator-stimulated Phosphoprotein-like Protein (EVL) via a Novel Carboxyl-terminal Zyxin-like Domain J. Biol. Chem., December 8, 2000; 275(50): 39647 - 39653. [Abstract] [Full Text] [PDF]

				R. Inatome, T. Tsujimura, T. Hitomi, N. Mitsui, P. Hermann, S.'i. Kuroda, H. Yamamura, and S. Yanagi Identification of CRAM, a Novel unc-33 Gene Family Protein That Associates with CRMP3 and Protein-tyrosine Kinase(s) in the Developing Rat Brain J. Biol. Chem., August 25, 2000; 275(35): 27291 - 27302. [Abstract] [Full Text] [PDF]