|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 11 2475-2481, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
R Battye, A Stevens and JR Jacobs
Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
Guidance of axons towards or away from the midline of the central nervous system during Drosophila embryogenesis reflects a balance of attractive and repulsive cues originating from the midline. Here we demonstrate that Slit, a protein secreted by the midline glial cells provides a repulsive cue for the growth cones of axons and muscle cells. Embryos lacking slit function show a medial collapse of lateral axon tracts and ectopic midline crossing of ventral muscles. Transgene expression of slit in the midline restores axon patterning. Ectopic expression of slit inhibits formation of axon tracts at locations of high Slit production and misdirects axon tracts towards the midline. slit interacts genetically with roundabout, which encodes a putative receptor for growth cone repulsion.
This article has been cited by other articles:
|
|
 |
|
  X. Sun, T. Morozova, and M. Sonnenfeld Glial and Neuronal Functions of the Drosophila Homolog of the Human SWI/SNF Gene ATR-X (DATR-X) and the jing Zinc-Finger Gene Specify the Lateral Positioning of Longitudinal Glia and Axons Genetics, July 1, 2006; 173(3): 1397 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. F. Barresi, L. D. Hutson, C.-B. Chien, and R. O. Karlstrom Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain Development, August 15, 2005; 132(16): 3643 - 3656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Forsthoefel, E. C. Liebl, P. A. Kolodziej, and M. A. Seeger The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila Development, April 15, 2005; 132(8): 1983 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gallio, C. Englund, P. Kylsten, and C. Samakovlis Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline Development, August 1, 2004; 131(15): 3605 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kanellis, G. E. Garcia, P. Li, G. Parra, C. B. Wilson, Y. Rao, S. Han, C. W. Smith, R. J. Johnson, J. Y. Wu, et al. Modulation of Inflammation by Slit Protein In Vivo in Experimental Crescentic Glomerulonephritis Am. J. Pathol., July 1, 2004; 165(1): 341 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Onel, L. Bolke, and C. Klambt The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit Development, June 1, 2004; 131(11): 2587 - 2594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kuja-Panula, M. Kiiltomaki, T. Yamashiro, A. Rouhiainen, and H. Rauvala AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats J. Cell Biol., March 17, 2003; 160(6): 963 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Crowner, K. Madden, S. Goeke, and E. Giniger Lola regulates midline crossing of CNS axons in Drosophila Development, March 5, 2003; 129(6): 1317 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Dickson Molecular Mechanisms of Axon Guidance Science, December 6, 2002; 298(5600): 1959 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Rao, K. Wong, M. Ward, C. Jurgensen, and J. Y. Wu Neuronal migration and molecular conservation with leukocyte chemotaxis Genes & Dev., December 1, 2002; 16(23): 2973 - 2984. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stevens and J. R. Jacobs Integrins Regulate Responsiveness to Slit Repellent Signals J. Neurosci., June 1, 2002; 22(11): 4448 - 4455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Englund, P. Steneberg, L. Falileeva, N. Xylourgidis, and C. Samakovlis Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea Development, January 11, 2002; 129(21): 4941 - 4951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Battye, A. Stevens, R. L. Perry, and J. R. Jacobs Repellent Signaling by Slit Requires the Leucine-Rich Repeats J. Neurosci., June 15, 2001; 21(12): 4290 - 4298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-h. Chen, L. Wen, S. Dupuis, J. Y. Wu, and Y. Rao The N-terminal Leucine-Rich Regions in Slit Are Sufficient To Repel Olfactory Bulb Axons and Subventricular Zone Neurons J. Neurosci., March 1, 2001; 21(5): 1548 - 1556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Erskine, S. E. Williams, K. Brose, T. Kidd, R. A. Rachel, C. S. Goodman, M. Tessier-Lavigne, and C. A. Mason Retinal Ganglion Cell Axon Guidance in the Mouse Optic Chiasm: Expression and Function of Robos and Slits J. Neurosci., July 1, 2000; 20(13): 4975 - 4982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Wolf and A. Chiba Axon pathfinding proceeds normally despite disrupted growth cone decisions at CNS midline Development, May 15, 2000; 127(10): 2001 - 2009. [Abstract] [PDF]
|
|
|
|
|
|
Q Sun, S Bahri, A Schmid, W Chia, and K Zinn Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo Development, January 2, 2000; 127(4): 801 - 812. [Abstract] [PDF]
|
|
|
|
|
|
S. Bertuzzi, R. Hindges, S. H. Mui, D. D.M. O'Leary, and G. Lemke The homeodomain protein Vax1 is required for axon guidance and major tract formation in the developing forebrain Genes & Dev., December 1, 1999; 13(23): 3092 - 3105. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Ronca, J. S. Andersen, V. Paech, and R. U. Margolis Characterization of Slit Protein Interactions with Glypican-1 J. Biol. Chem., July 27, 2001; 276(31): 29141 - 29147. [Abstract] [Full Text] [PDF]
|
|
