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Development, Vol 126, Issue 11 2563-2575, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Cbfa2 is required for the formation of intra-aortic hematopoietic clusters

T North, TL Gu, T Stacy, Q Wang, L Howard, M Binder, M Marin-Padilla and NA Speck
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

Cbfa2 (AML1) encodes the DNA-binding subunit of a transcription factor in the small family of core-binding factors (CBFs). Cbfa2 is required for the differentiation of all definitive hematopoietic cells, but not for primitive erythropoiesis. Here we show that Cbfa2 is expressed in definitive hematopoietic progenitor cells, and in endothelial cells in sites from which these hematopoietic cells are thought to emerge. Endothelial cells expressing Cbfa2 are in the yolk sac, the vitelline and umbilical arteries, and in the ventral aspect of the dorsal aorta in the aorta/genital ridge/mesonephros (AGM) region. Endothelial cells lining the dorsal aspect of the aorta, and elsewhere in the embryo, do not express Cbfa2. Cbfa2 appears to be required for maintenance of Cbfa2 expression in the endothelium, and for the formation of intra-aortic hematopoietic clusters from the endothelium.
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R. A. J. Oostendorp, K. N. Harvey, N. Kusadasi, M. F. T. R. de Bruijn, C. Saris, R. E. Ploemacher, A. L. Medvinsky, and E. A. Dzierzak
Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
Blood, February 15, 2002; 99(4): 1183 - 1189.
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P. Kumaravelu, L. Hook, A. M. Morrison, J. Ure, S. Zhao, S. Zuyev, J. Ansell, and A. Medvinsky
Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
Development, January 11, 2002; 129(21): 4891 - 4899.
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J. D. Miller, T. Stacy, P. P. Liu, and N. A. Speck
Core-binding factor {beta} (CBF{beta}), but not CBF{beta}-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBF{beta}-deficient embryonic stem cells
Blood, April 15, 2001; 97(8): 2248 - 2256.
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M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Development, January 5, 2001; 128(10): 1717 - 1730.
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C. J. Marshall, C. Kinnon, and A. J. Thrasher
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region
Blood, August 15, 2000; 96(4): 1591 - 1593.
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A. Pozner, D. Goldenberg, V. Negreanu, S.-Y. Le, O. Elroy-Stein, D. Levanon, and Y. Groner
Transcription-Coupled Translation Control of AML1/RUNX1 Is Mediated by Cap- and Internal Ribosome Entry Site-Dependent Mechanisms
Mol. Cell. Biol., April 1, 2000; 20(7): 2297 - 2307.
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T. L. Goetz, T.-L. Gu, N. A. Speck, and B. J. Graves
Auto-Inhibition of Ets-1 Is Counteracted by DNA Binding Cooperativity with Core-Binding Factor alpha 2
Mol. Cell. Biol., January 1, 2000; 20(1): 81 - 90.
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T.-L. Gu, T. L. Goetz, B. J. Graves, and N. A. Speck
Auto-Inhibition and Partner Proteins, Core-Binding Factor beta (CBFbeta ) and Ets-1, Modulate DNA Binding by CBFalpha 2 (AML1)
Mol. Cell. Biol., January 1, 2000; 20(1): 91 - 103.
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