|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 12 2653-2662, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
JF de Celis, R Barrio and FC Kafatos
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. jdc@mole.bio.cam.ac.uk
The nuclear proteins Spalt and Spalt-related belong to a conserved family of transcriptional regulators characterised by the presence of double zinc-finger domains. In the wing, they are regulated by the secreted protein Decapentaplegic and participate in the positioning of the wing veins. Here, we identify regulatory regions in the spalt/spalt-related gene complex that direct expression in the wing disc. The regulatory sequences are organised in independent modules, each of them responsible for expression in particular domains of the wing imaginal disc. In the thorax, spalt and spalt-related are expressed in a restricted domain that includes most proneural clusters of the developing sensory organs in the notum, and are regulated by the signalling molecules Wingless, Decapentaplegic and Hedgehog. We find that spalt/spalt-related participate in the development of sensory organs in the thorax, mainly in the positioning of specific proneural clusters. Later, the expression of at least spalt is eliminated from the sensory organ precursor cells and this is a requisite for the differentiation of these cells. We postulate that spalt and spalt-related belong to a category of transcriptional regulators that subdivide the thorax into expression domains (prepattern) required for the localised activation of proneural genes.
This article has been cited by other articles:
|
|
 |
|
  S. J. Harrison, R. Nishinakamura, and A. P. Monaghan Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb Cereb Cortex, July 1, 2008; 18(7): 1604 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bollenbach, P. Pantazis, A. Kicheva, C. Bokel, M. Gonzalez-Gaitan, and F. Julicher Precision of the Dpp gradient Development, March 15, 2008; 135(6): 1137 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Barembaum and M. Bronner-Fraser Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm Development, November 1, 2007; 134(21): 3805 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Molnar, H. Holguin, F. Mayor Jr., A. Ruiz-Gomez, and J. F. de Celis The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila PNAS, May 8, 2007; 104(19): 7963 - 7968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. de Navascues and J. Modolell tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification Development, May 1, 2007; 134(9): 1779 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sakaki-Yumoto, C. Kobayashi, A. Sato, S. Fujimura, Y. Matsumoto, M. Takasato, T. Kodama, H. Aburatani, M. Asashima, N. Yoshida, et al. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development Development, August 1, 2006; 133(15): 3005 - 3013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Munoz-Sanjuan and A. H. Brivanlou Induction of Ectopic Olfactory Structures and Bone Morphogenetic Protein Inhibition by Rossy, a Group XII Secreted Phospholipase A2 Mol. Cell. Biol., May 1, 2005; 25(9): 3608 - 3619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Parrish, T. Ott, C. Lance-Jones, G. Schuetz, A. Schwaeger-Nickolenko, and A. P. Monaghan Loss of the Sall3 Gene Leads to Palate Deficiency, Abnormalities in Cranial Nerves, and Perinatal Lethality Mol. Cell. Biol., August 15, 2004; 24(16): 7102 - 7112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Barrio and J. F. de Celis Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway PNAS, April 20, 2004; 101(16): 6021 - 6026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Harbison, A. H. Yamamoto, J. J. Fanara, K. K. Norga, and T. F. C. Mackay Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster Genetics, April 1, 2004; 166(4): 1807 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. S. Dong, S. V. Todi, D. F. Eberl, and G. Boekhoff-Falk Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes PNAS, September 2, 2003; 100(18): 10293 - 10298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cantera, K. Luer, T. E. Rusten, R. Barrio, F. C. Kafatos, and G. M. Technau Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster Development, March 14, 2003; 129(24): 5577 - 5586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sweetman, T. Smith, E. R. Farrell, A. Chantry, and A. Munsterberg The Conserved Glutamine-rich Region of Chick Csal1 and Csal3 Mediates Protein Interactions with Other Spalt Family Members. IMPLICATIONS FOR TOWNES-BROCKS SYNDROME J. Biol. Chem., February 14, 2003; 278(8): 6560 - 6566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Rusten, R Cantera, J Urban, G Technau, F. Kafatos, and R Barrio Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes Development, January 3, 2001; 128(5): 711 - 722. [Abstract] [PDF]
|
|
|
|
 |
|
 D. A. Papatsenko, V. J. Makeev, A. P. Lifanov, M. Regnier, A. G. Nazina, and C. Desplan Extraction of Functional Binding Sites from Unique Regulatory Regions: The Drosophila Early Developmental Enhancers Genome Res., March 1, 2002; 12(3): 470 - 481. [Abstract] [Full Text] [PDF]
|
|
