|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 13 2945-2954, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
A Daniel, K Dumstrei, JA Lengyel and V Hartenstein
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095-1606, USA.
We describe here the role of the transcription factors encoding genes tailless (tll), atonal (ato), sine oculis (so), eyeless (ey) and eyes absent (eya), and EGFR signaling in establishing the Drosophila embryonic visual system. The embryonic visual system consists of the optic lobe primordium, which, during later larval life, develops into the prominent optic lobe neuropiles, and the larval photoreceptor (Bolwig's organ). Both structures derive from a neurectodermal placode in the embryonic head. Expression of tll is normally confined to the optic lobe primordium, whereas ato appears in a subset of Bolwig's organ cells that we call Bolwig's organ founders. Phenotypic analysis, using specific markers for Bolwig's organ and the optic lobe, of tll loss- and gain-of-function mutant embryos reveals that tll functions to drive cells to optic lobe as opposed to Bolwig's organ fate. Similar experiments indicate that ato has the opposite effect, namely driving cells to a Bolwig's organ fate. Since we can show that tll and ato do not regulate each other, we propose a model wherein tll expression restricts the ability of cells to respond to signaling arising from ato-expressing Bolwig's organ pioneers. Our data further suggest that the Bolwig's organ founder cells produce Spitz (the Drosophila TGFalpha homolog) signal, which is passed to the neighboring secondary Bolwig's organ cells where it activates the EGFR signaling cascade and maintains the fate of these secondary cells. The regulators of tll expression in the embryonic visual system remain elusive, as we were unable to find evidence for regulation by the 'early eye genes' so, eya and ey, or by EGFR signaling.
This article has been cited by other articles:
|
|
 |
|
  S. G. Sprecher, F. Pichaud, and C. Desplan Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates Genes & Dev., September 1, 2007; 21(17): 2182 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schmitt, M. Prestel, and R. Paro Intergenic transcription through a Polycomb group response element counteracts silencing Genes & Dev., March 15, 2005; 19(6): 697 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Caldwell, M. M. Miller, S. Wing, D. R. Soll, and D. F. Eberl Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutants PNAS, December 23, 2003; 100(26): 16053 - 16058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Zuber, G. Gestri, A. S. Viczian, G. Barsacchi, and W. A. Harris Specification of the vertebrate eye by a network of eye field transcription factors Development, November 1, 2003; 130(21): 5155 - 5167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Helfrich-Forster, T. Edwards, K. Yasuyama, B. Wisotzki, S. Schneuwly, R. Stanewsky, I. A. Meinertzhagen, and A. Hofbauer The Extraretinal Eyelet of Drosophila: Development, Ultrastructure, and Putative Circadian Function J. Neurosci., November 1, 2002; 22(21): 9255 - 9266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dumstrei, F. Wang, D. Shy, U. Tepass, and V. Hartenstein Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis Development, September 1, 2002; 129(17): 3983 - 3994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Arendt, K. Tessmar, M.-I. M. de Campos-Baptista, A. Dorresteijn, and J. Wittbrodt Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria Development, January 3, 2002; 129(5): 1143 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Milam, L. Rose, A. V. Cideciyan, M. R. Barakat, W.-X. Tang, N. Gupta, T. S. Aleman, A. F. Wright, E. M. Stone, V. C. Sheffield, et al. The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration PNAS, January 1, 2002; (2002) 22533099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. B. Haider, J. Naggert, and P. M. Nishina Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice Hum. Mol. Genet., August 1, 2001; 10(16): 1619 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Hassan and H. J. Bellen Doing the MATH: is the mouse a good model for fly development? Genes & Dev., August 1, 2000; 14(15): 1852 - 1865. [Full Text]
|
|
|
|
|
|
A Noveen, A Daniel, and V Hartenstein Early development of the Drosophila mushroom body: the roles of eyeless and dachshund Development, January 8, 2000; 127(16): 3475 - 3488. [Abstract] [PDF]
|
|
|
|
|
|
T Suzuki and K Saigo Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus Development, January 4, 2000; 127(7): 1531 - 1540. [Abstract] [PDF]
|
|
|
|
|
|
A. H. Milam, L. Rose, A. V. Cideciyan, M. R. Barakat, W.-X. Tang, N. Gupta, T. S. Aleman, A. F. Wright, E. M. Stone, V. C. Sheffield, et al. From the Cover: The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration PNAS, January 8, 2002; 99(1): 473 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Yu, M.-Y. Chiang, T. Tanabe, M. Kobayashi, K. Yasuda, R. M. Evans, and K. Umesono The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision PNAS, March 14, 2000; 97(6): 2621 - 2625. [Abstract] [Full Text] [PDF]
|
|
