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Development, Vol 126, Issue 15 3275-3283, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
G Seydoux and S Strome
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. gseydoux@jhmi.edu
One hundred years after Weismann's seminal observations, the mechanisms that distinguish the germline from the soma still remain poorly understood. This review describes recent studies in Caenorhabditis elegans, which suggest that germ cells utilize unique mechanisms to regulate gene expression. In particular, mechanisms that repress the production of mRNAs appear to be essential to maintain germ cell fate and viability.
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