|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 15 3347-3357, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
C Chang and A Hemmati-Brivanlou
Department of Molecular Embryology, The Rockefeller University, New York, NY 10021, USA.
In Xenopus, ectodermal cell fates are determined by antagonistic interaction between the BMP subfamily of TGF-(beta) ligands and the organizer-specific secreted factors (e.g. noggin, chordin and follistatin). Inhibition of BMP function by these factors can convert cells from an epidermal to a neural cell fate. In this study, we report that GDF6, a new member of the Xenopus TGF-(beta) family, can function in antagonistic interaction with neural inducers. GDF6 induces epidermis and inhibits neural tissue in dissociated cells, and this activity is blocked by the presence of noggin. We demonstrate that GDF6 binds directly to the neural inducer noggin. Furthermore, we find that GDF6 and BMP2 can form heterodimers and the process seems to require cotranslation of the proteins in the same cells. In normal embryos, GDF6 and BMP2 are coexpressed in several places, including the edge of the neural plate at early neurula stages, suggesting that GDF6 may synergize with BMPs to regulate patterning of the ectoderm. Our data show for the first time that noggin can bind directly to and inhibit another TGF-(beta) family member: GDF6. In addition, BMP and GDF6 heterodimers may play an important role in vivo to regulate cell fate determination and patterning.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. T. Thomas, P. Canelos, F. P. Luyten, and M. Moos Jr. Xenopus SMOC-1 Inhibits Bone Morphogenetic Protein Signaling Downstream of Receptor Binding and Is Essential for Postgastrulation Development in Xenopus J. Biol. Chem., July 10, 2009; 284(28): 18994 - 19005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nakajima, H. Okamoto, and T. Kubo Expression cloning of Xenopus zygote arrest 2 (Xzar2) as a novel epidermalization-promoting factor in early embryos of Xenopus laevis Genes Cells, May 1, 2009; 14(5): 583 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Gosse and H. Baier An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina PNAS, February 17, 2009; 106(7): 2236 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Shi, C. Chang, S. Nie, S. Xie, M. Wan, and X. Cao Endofin acts as a Smad anchor for receptor activation in BMP signaling J. Cell Sci., April 1, 2007; 120(7): 1216 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Thomas, D. Prakash, K. Weih, and M. Moos Jr. CDMP1/GDF5 Has Specific Processing Requirements That Restrict Its Action to Joint Surfaces J. Biol. Chem., September 8, 2006; 281(36): 26725 - 26733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses J. Biol. Chem., September 16, 2005; 280(37): 32122 - 32132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sidi, C. Goutel, N. Peyrieras, and F. M. Rosa Maternal induction of ventral fate by zebrafish radar PNAS, March 18, 2003; 100(6): 3315 - 3320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Faber, M. L. Robinson, H. P. Makarenkova, and R. A. Lang Bmp signaling is required for development of primary lens fiber cells Development, August 1, 2002; 129(15): 3727 - 3737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iwata, Y. Morotome, T. Tanabe, M. Fukae, I. Ishikawa, and S. Oida Noggin Blocks Osteoinductive Activity of Porcine Enamel Extracts Journal of Dental Research, June 1, 2002; 81(6): 387 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Reissmann, H. Jornvall, A. Blokzijl, O. Andersson, C. Chang, G. Minchiotti, M. G. Persico, C. F. Ibanez, and A. H. Brivanlou The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development Genes & Dev., August 1, 2001; 15(15): 2010 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Dionne, W. C. Skarnes, and R. M. Harland Mutation and Analysis of Dan, the Founding Member of the Dan Family of Transforming Growth Factor {beta} Antagonists Mol. Cell. Biol., January 15, 2001; 21(2): 636 - 643. [Abstract] [Full Text]
|
|
|
|
|
|
J. Massagué and Y.-G. Chen Controlling TGF-beta signaling Genes & Dev., March 15, 2000; 14(6): 627 - 644. [Full Text]
|
|
|
|
|
|
J Shou, R. Murray, P. Rim, and A. Calof Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage Development, January 12, 2000; 127(24): 5403 - 5413. [Abstract] [PDF]
|
|
|
|
|
|
K Miyazono Positive and negative regulation of TGF-beta signaling J. Cell Sci., January 4, 2000; 113(7): 1101 - 1109. [Abstract] [PDF]
|
|
|
|
|
|
A. Ramsdell and H. Yost Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway Development, January 12, 1999; 126(23): 5195 - 5205. [Abstract] [PDF]
|
|
|
|
|
|
J. Marcelino, C. M. Sciortino, M. F. Romero, L. M. Ulatowski, R. T. Ballock, A. N. Economides, P. M. Eimon, R. M. Harland, and M. L. Warman Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding PNAS, September 25, 2001; 98(20): 11353 - 11358. [Abstract] [Full Text] [PDF]
|
|
