|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 15 3415-3424, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
Y Hamada, Y Kadokawa, M Okabe, M Ikawa, JR Coleman and Y Tsujimoto
National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan. hamada@nibb.ac.jp
Notch family genes encode transmembrane proteins involved in cell-fate determination. Using gene targeting procedures, we disrupted the mouse Notch2 gene by replacing all but one of the ankyrin repeat sequences in the cytoplasmic domain with the E. coli (beta)-galactosidase gene. The mutant Notch2 gene encodes a 380 kDa Notch2-(beta)-gal fusion protein with (beta)-galactosidase activity. Notch2 homozygous mutant mice die prior to embryonic day 11.5, whereas heterozygotes show no apparent abnormalities and are fully viable. Analysis of Notch2 expression patterns, revealed by X-gal staining, demonstrated that the Notch2 gene is expressed in a wide variety of tissues including neuroepithelia, somites, optic vesicles, otic vesicles, and branchial arches, but not heart. Histological studies, including in situ nick end labeling procedures, showed earlier onset and higher incidence of apoptosis in homozygous mutant mice than in heterozygotes or wild type mice. Dying cells were particularly evident in neural tissues, where they were seen as early as embryonic day 9.5 in Notch2-deficient mice. Cells from Notch2 mutant mice attach and grow normally in culture, demonstrating that Notch2 deficiency does not interfere with cell proliferation and that expression of the Notch2-(beta)-gal fusion protein is not toxic per se. In contrast to Notch1-deficient mice, Notch2 mutant mice did not show disorganized somitogenesis, nor did they fail to properly regulate the expression of neurogenic genes such as Hes-5 or Mash1. In situ hybridization studies show no indication of altered Notch1 expression patterns in Notch2 mutant mice. The results indicate that Notch2 plays an essential role in postimplantation development in mice, probably in some aspect of cell specification and/or differentiation, and that the ankyrin repeats are indispensable for its function.
This article has been cited by other articles:
|
|
 |
|
  L. Zhou, L. W. Li, Q. Yan, B. Petryniak, Y. Man, C. Su, J. Shim, S. Chervin, and J. B. Lowe Notch-dependent control of myelopoiesis is regulated by fucosylation Blood, July 15, 2008; 112(2): 308 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Niessen and A. Karsan Notch Signaling in Cardiac Development Circ. Res., May 23, 2008; 102(10): 1169 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bai, R. Kopan, W. Zou, M. J. Hilton, C.-t. Ong, F. Long, F. P. Ross, and S. L. Teitelbaum NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells J. Biol. Chem., March 7, 2008; 283(10): 6509 - 6518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pascoal and I. Palmeirim Watch-ing out for chick limb development Integr. Comp. Biol., September 1, 2007; 47(3): 382 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Niessen and A. Karsan Notch signaling in the developing cardiovascular system Am J Physiol Cell Physiol, July 1, 2007; 293(1): C1 - C11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Taylor, K. Yeager, and S. J. Morrison Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems Development, July 1, 2007; 134(13): 2435 - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hofmann and M. L. Iruela-Arispe Notch Signaling in Blood Vessels: Who Is Talking to Whom About What? Circ. Res., June 8, 2007; 100(11): 1556 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Besseyrias, E. Fiorini, L. J. Strobl, U. Zimber-Strobl, A. Dumortier, U. Koch, M.-L. Arcangeli, S. Ezine, H. R. MacDonald, and F. Radtke Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation J. Exp. Med., February 19, 2007; 204(2): 331 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Song, B.-K. Koo, K.-J. Yoon, M.-J. Yoon, K.-W. Yoo, H.-T. Kim, H.-J. Oh, Y.-Y. Kim, J.-K. Han, C.-H. Kim, et al. Neuralized-2 Regulates a Notch Ligand in Cooperation with Mind Bomb-1 J. Biol. Chem., November 24, 2006; 281(47): 36391 - 36400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Rutenberg, A. Fischer, H. Jia, M. Gessler, T. P. Zhong, and M. Mercola Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors Development, November 1, 2006; 133(21): 4381 - 4390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chiba Concise Review: Notch Signaling in Stem Cell Systems Stem Cells, November 1, 2006; 24(11): 2437 - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Hoek, P. Antony, J. Lowe, N. Shinners, B. Sarmah, S. R. Wente, D. Wang, R. M. Gerstein, and W. N. Khan Transitional B Cell Fate Is Associated with Developmental Stage-Specific Regulation of Diacylglycerol and Calcium Signaling upon B Cell Receptor Engagement J. Immunol., October 15, 2006; 177(8): 5405 - 5413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Weinmaster and R. Kopan A garden of Notch-ly delights Development, September 1, 2006; 133(17): 3277 - 3282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cormier, S. Le Bras, C. Souilhol, S. Vandormael-Pournin, B. Durand, C. Babinet, P. Baldacci, and M. Cohen-Tannoudji The Murine Ortholog of Notchless, a Direct Regulator of the Notch Pathway in Drosophila melanogaster, Is Essential for Survival of Inner Cell Mass Cells. Mol. Cell. Biol., May 1, 2006; 26(9): 3541 - 3549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Watanabe, H. Kokubo, S. Miyagawa-Tomita, M. Endo, K. Igarashi, K. i. Aisaki, J. Kanno, and Y. Saga Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse Development, May 1, 2006; 133(9): 1625 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Duvillie, M. Attali, A. Bounacer, P. Ravassard, A. Basmaciogullari, and R. Scharfmann The Mesenchyme Controls the Timing of Pancreatic {beta}-Cell Differentiation Diabetes, March 1, 2006; 55(3): 582 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Thomsen, P. Horn, F. Panitz, E. Bendixen, A. H. Petersen, L.-E. Holm, V. H. Nielsen, J. S. Agerholm, J. Arnbjerg, and C. Bendixen A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation Genome Res., January 1, 2006; 16(1): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen and Q. Al-Awqati Segmental expression of Notch and Hairy genes in nephrogenesis Am J Physiol Renal Physiol, May 1, 2005; 288(5): F939 - F952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Dando, M. Tavian, C. Catelain, S. Poirault, A. Bennaceur-Griscelli, F. Sainteny, W. Vainchenker, B. Peault, and E. Lauret Notch/Delta4 Interaction in Human Embryonic Liver CD34+ CD38- Cells: Positive Influence on BFU-E Production and LTC-IC Potential Maintenance Stem Cells, April 1, 2005; 23(4): 550 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls Lunatic fringe null female mice are infertile due to defects in meiotic maturation Development, February 15, 2005; 132(4): 817 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lorent, S.-Y. Yeo, T. Oda, S. Chandrasekharappa, A. Chitnis, R. P. Matthews, and M. Pack Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy Development, November 15, 2004; 131(22): 5753 - 5766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hatakeyama, Y. Bessho, K. Katoh, S. Ookawara, M. Fujioka, F. Guillemot, and R. Kageyama Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation Development, November 15, 2004; 131(22): 5539 - 5550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tanimizu and A. Miyajima Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors J. Cell Sci., July 1, 2004; 117(15): 3165 - 3174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Tetzlaff, W. Yu, M. Li, P. Zhang, M. Finegold, K. Mahon, J. W. Harper, R. J. Schwartz, and S. J. Elledge Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS, March 9, 2004; 101(10): 3338 - 3345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. V. Kalinichenko, G. A. Gusarova, I.-M. Kim, B. Shin, H. M. Yoder, J. Clark, A. M. Sapozhnikov, J. A. Whitsett, and R. H. Costa Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L521 - L530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Duan, F.-Q. Li, J. Wechsler, K. Meade-White, K. Williams, K. F. Benson, and M. Horwitz A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia Mol. Cell. Biol., January 1, 2004; 24(1): 58 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Witt, V. Hurez, C. S. Swindle, Y. Hamada, and C. A. Klug Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells Mol. Cell. Biol., December 1, 2003; 23(23): 8637 - 8650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-T. Cheng, J. H. Miner, M. Lin, M. G. Tansey, K. Roth, and R. Kopan {gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney Development, October 15, 2003; 130(20): 5031 - 5042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Witt, W.-J. Won, V. Hurez, and C. A. Klug Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells J. Immunol., September 15, 2003; 171(6): 2783 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shi and P. Stanley Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways PNAS, April 29, 2003; 100(9): 5234 - 5239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Small, D. Kovalenko, R. Soldi, A. Mandinova, V. Kolev, R. Trifonova, C. Bagala, D. Kacer, C. Battelli, L. Liaw, et al. Notch Activation Suppresses Fibroblast Growth Factor-dependent Cellular Transformation J. Biol. Chem., April 25, 2003; 278(18): 16405 - 16413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Iso, Y. Hamamori, and L. Kedes Notch Signaling in Vascular Development Arterioscler. Thromb. Vasc. Biol., April 1, 2003; 23(4): 543 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Karlstrom, P. Beatus, K. Dannaeus, G. Chapman, U. Lendahl, and J. Lundkvist A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling PNAS, December 24, 2002; 99(26): 17119 - 17124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-E. Lin, T. Oyama, T. Nagase, K. Harigaya, and M. Kitagawa Identification of New Human Mastermind Proteins Defines a Family That Consists of Positive Regulators for Notch Signaling J. Biol. Chem., December 20, 2002; 277(52): 50612 - 50620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Campos, W. Wang, M. J. Pollman, and G. H. Gibbons Determinants of Notch-3 Receptor Expression and Signaling in Vascular Smooth Muscle Cells: Implications in Cell-Cycle Regulation Circ. Res., November 29, 2002; 91(11): 999 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, A. H. Campos, C. Z. Prince, Y. Mou, and M. J. Pollman Coordinate Notch3-Hairy-related Transcription Factor Pathway Regulation in Response to Arterial Injury. MEDIATOR ROLE OF PLATELET-DERIVED GROWTH FACTOR AND ERK J. Biol. Chem., June 21, 2002; 277(26): 23165 - 23171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, C. Z. Prince, Y. Mou, and M. J. Pollman Notch3 Signaling in Vascular Smooth Muscle Cells Induces c-FLIP Expression via ERK/MAPK Activation. RESISTANCE TO Fas LIGAND-INDUCED APOPTOSIS J. Biol. Chem., June 7, 2002; 277(24): 21723 - 21729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vollrath, J. Pudney, S. Asa, P. Leder, and K. Fitzgerald Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland Mol. Cell. Biol., November 1, 2001; 21(21): 7481 - 7494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Saxena, E. H. Schroeter, J. S. Mumm, and R. Kopan Murine Notch Homologs (N1-4) Undergo Presenilin-dependent Proteolysis J. Biol. Chem., October 19, 2001; 276(43): 40268 - 40273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B McCright, X Gao, L Shen, J Lozier, Y Lan, M Maguire, D Herzlinger, G Weinmaster, R Jiang, and T Gridley Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation Development, January 2, 2001; 128(4): 491 - 502. [Abstract] [PDF]
|
|
|
|
 |
|
 X. YANG, M. HANDLER, and J. SHEN Role of Presenilin-1 in Murine Neural Development Ann. N.Y. Acad. Sci., December 1, 2000; 920(1): 165 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eddison, I. Le Roux, and J. Lewis Notch signaling in the development of the inner ear: Lessons from Drosophila PNAS, October 24, 2000; 97(22): 11692 - 11699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Stone and E. W Rubel Cellular studies of auditory hair cell regeneration in birds PNAS, October 24, 2000; 97(22): 11714 - 11721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimizu, S. Chiba, N. Hosoya, K. Kumano, T. Saito, M. Kurokawa, Y. Kanda, Y. Hamada, and H. Hirai Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 Mol. Cell. Biol., September 15, 2000; 20(18): 6913 - 6922. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. T. Krebs, Y. Xue, C. R. Norton, J. R. Shutter, M. Maguire, J. P. Sundberg, D. Gallahan, V. Closson, J. Kitajewski, R. Callahan, et al. Notch signaling is essential for vascular morphogenesis in mice Genes & Dev., June 1, 2000; 14(11): 1343 - 1352. [Abstract] [Full Text]
|
|
|
|
|
|
M Handler, X Yang, and J Shen Presenilin-1 regulates neuronal differentiation during neurogenesis Development, January 6, 2000; 127(12): 2593 - 2606. [Abstract] [PDF]
|
|
|
|
|
|
L. T. Lam, C. Ronchini, J. Norton, A. J. Capobianco, and E. H. Bresnick Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1 J. Biol. Chem., June 23, 2000; 275(26): 19676 - 19684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Morimura, R. Goitsuka, Y. Zhang, I. Saito, M. Reth, and D. Kitamura Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells J. Biol. Chem., November 17, 2000; 275(47): 36523 - 36531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ingles-Esteve, L. Espinosa, L. A. Milner, C. Caelles, and A. Bigas Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation J. Biol. Chem., November 21, 2001; 276(48): 44873 - 44880. [Abstract] [Full Text] [PDF]
|
|
