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Development, Vol 126, Issue 15 3449-3459, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway

JH Thomas and HR Horvitz
Howard Hughes Medical Institute, Department of Biology, Room 68-425, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

The Caenorhabditis elegans gene lin-36 acts to antagonize Ras-mediated vulval induction in a pathway that includes genes with products similar to the mammalian retinoblastoma (Rb) protein and the Rb-binding protein p48. We report that lin-36 encodes a novel protein of 962 amino acids. We demonstrate that lin-36 functions in and is expressed in the vulval precursor cells, establishing that the lin-36 pathway is involved in intercellular signaling. We also report that the lin-36 pathway and/or another pathway that is functionally redundant with the lin-36 pathway antagonize a ligand-independent activity of the receptor tyrosine kinase/Ras vulval induction pathway.
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