|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 16 3509-3521, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
S Noramly, A Freeman and BA Morgan
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Intercellular signaling by a subset of Wnts is mediated by stabilization of cytoplasmic beta-catenin and its translocation to the nucleus. Immunolocalization of beta-catenin in developing chick skin reveals that this signaling pathway is active in a dynamic pattern from the earliest stages of feather bud development. Forced activation of this pathway by expression of a stabilized beta-catenin in the ectoderm results in the ectopic formation of feather buds. This construct is sufficient to induce bud formation since it does so both within presumptive feather tracts and in normally featherless regions where tract-specific signals are absent. It is also insensitive to the lateral inhibition that mediates the normal spacing of buds and can induce ectopic buds in interfollicular skin. However, additional patterning signals cooperate with this pathway to regulate gene expression within domains of stabilized beta-catenin expression. Localized activation of this pathway within the bud as it develops is required for normal morphogenesis and ectopic activation of the pathway leads to abnormally oriented buds and growths on the feather filaments. These results suggest that activation of the beta-catenin pathway initiates follicle development in embryonic skin and plays important roles in the subsequent morphogenesis of the bud.
This article has been cited by other articles:
|
|
 |
|
  F. Michon, L. Forest, E. Collomb, J. Demongeot, and D. Dhouailly BMP2 and BMP7 play antagonistic roles in feather induction Development, August 15, 2008; 135(16): 2797 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Narhi, E. Jarvinen, W. Birchmeier, M. M. Taketo, M. L. Mikkola, and I. Thesleff Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation Development, March 15, 2008; 135(6): 1019 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wu, R. F. Xu, L. Xiao, H. Xu, and G. Gao Expression of the -Catenin Gene in the Skin of Embryonic Geese During Feather Bud Development Poult. Sci., January 1, 2008; 87(1): 204 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Hens, P. Dann, J.-P. Zhang, S. Harris, G. W. Robinson, and J. Wysolmerski BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction Development, March 15, 2007; 134(6): 1221 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Iwatsuki, H.-X. Liu, A. Gronder, M. A. Singer, T. F. Lane, R. Grosschedl, C. M. Mistretta, and R. F. Margolskee Wnt signaling interacts with Shh to regulate taste papilla development PNAS, February 13, 2007; 104(7): 2253 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kurek, G. A. Garinis, J. H. van Doorninck, J. van der Wees, and F. G. Grosveld Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles Development, January 15, 2007; 134(2): 261 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pummila, I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff, and M. L. Mikkola Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression Development, January 1, 2007; 134(1): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E. Lowry, C. Blanpain, J. A. Nowak, G. Guasch, L. Lewis, and E. Fuchs Defining the impact of {beta}-catenin/Tcf transactivation on epithelial stem cells Genes & Dev., July 1, 2005; 19(13): 1596 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Eames and R. A. Schneider Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development Development, April 1, 2005; 132(7): 1499 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Houghton, C. Lindon, and B. A. Morgan The ectodysplasin pathway in feather tract development Development, March 1, 2005; 132(5): 863 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mustonen, M. Ilmonen, M. Pummila, A. T. Kangas, J. Laurikkala, R. Jaatinen, J. Pispa, O. Gaide, P. Schneider, I. Thesleff, et al. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages Development, October 15, 2004; 131(20): 4907 - 4919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mandler and A. Neubuser FGF signaling is required for initiation of feather placode development Development, July 15, 2004; 131(14): 3333 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yuhki, M. Yamada, M. Kawano, T. Iwasato, S. Itohara, H. Yoshida, M. Ogawa, and Y. Mishina BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice Development, April 15, 2004; 131(8): 1825 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Laurikkala, J. Pispa, H.-S. Jung, P. Nieminen, M. Mikkola, X. Wang, U. Saarialho-Kere, J. Galceran, R. Grosschedl, and I. Thesleff Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar Development, March 7, 2003; 129(10): 2541 - 2553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. DasGupta, H. Rhee, and E. Fuchs A developmental conundrum: a stabilized form of {beta}-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells J. Cell Biol., July 22, 2002; 158(2): 331 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Thesleff and M. L. Mikkola Death Receptor Signaling Giving Life to Ectodermal Organs Sci. Signal., May 7, 2002; 2002(131): pe22 - pe22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tavares, T Tsukui, and J. Izpisua Belmonte Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development Development, January 12, 2000; 127(23): 5133 - 5144. [Abstract] [PDF]
|
|
|
|
|
|
T. Jiang, H. Jung, R. Widelitz, and C. Chuong Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia Development, January 11, 1999; 126(22): 4997 - 5009. [Abstract] [PDF]
|
|
