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Development, Vol 126, Issue 17 3795-3809, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5

D Acampora, GR Merlo, L Paleari, B Zerega, MP Postiglione, S Mantero, E Bober, O Barbieri, A Simeone and G Levi
International Institute of Genetic and Biophysics, CNR, via Marconi 10, Italy.

The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo. In later developmental stages, it appears in the branchial arches, the otic and olfactory placodes and their derivatives, in restricted brain regions, in all extending appendages and in all developing bones. We have created a null allele of the mouse Dlx5 gene by replacing exons I and II with the E. coli lacZ gene. Heterozygous mice appear normal. Beta-galactosidase activity in Dlx5+/- embryos and newborn animals reproduces the known pattern of expression of the gene. Homozygous mutants die shortly after birth with a swollen abdomen. They present a complex phenotype characterised by craniofacial abnormalities affecting derivatives of the first four branchial arches, severe malformations of the vestibular organ, a delayed ossification of the roof of the skull and abnormal osteogenesis. No obvious defect was observed in the patterning of limbs and other appendages. The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.
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[Abstract] [Full Text] [PDF]

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Home page
 J. Neurosci.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
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Genes & Dev., June 15, 2002; 16(12): 1446 - 1465.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
R. F. Robledo, L. Rajan, X. Li, and T. Lufkin
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
Genes & Dev., May 1, 2002; 16(9): 1089 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
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Developmental functions of the Distal-less/Dlx homeobox genes
Development, January 10, 2002; 129(19): 4371 - 4386.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
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Concerted action of two dlx paralogs in sensory placode formation
Development, January 7, 2002; 129(13): 3127 - 3136.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Wang, E. K. Chan, S. Baron, T. Van De Water, and T. Lufkin
Hmx2 homeobox gene control of murine vestibular morphogenesis
Development, December 15, 2001; 128(24): 5017 - 5029.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Charite, D. G. McFadden, G. Merlo, G. Levi, D. E. Clouthier, M. Yanagisawa, J. A. Richardson, and E. N. Olson
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer
Genes & Dev., November 15, 2001; 15(22): 3039 - 3049.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
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Genetic Architecture of Mandible Shape in Mice: Effects of Quantitative Trait Loci Analyzed by Geometric Morphometrics
Genetics, February 1, 2001; 157(2): 785 - 802.
[Abstract] [Full Text]

Home page
 CROBMHome page
M. Mina
Regulation of Mandibular Growth and Morphogenesis
Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(4): 276 - 300.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. V. Brigande, A. E. Kiernan, X. Gao, L. E. Iten, and D. M. Fekete
Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
PNAS, October 24, 2000; 97(22): 11700 - 11706.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Cantos, L. K. Cole, D. Acampora, A. Simeone, and D. K. Wu
Patterning of the mammalian cochlea
PNAS, October 24, 2000; 97(22): 11707 - 11713.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. Ducy, T. Schinke, and G. Karsenty
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Science, September 1, 2000; 289(5484): 1501 - 1504.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
J. Dixon, C. Brakebusch, R. Fassler, and M. J. Dixon
Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome
Hum. Mol. Genet., June 12, 2000; 9(10): 1473 - 1480.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Benson, J. L. Bargeon, G. Xiao, P. E. Thomas, A. Kim, Y. Cui, and R. T. Franceschi
Identification of a Homeodomain Binding Element in the Bone Sialoprotein Gene Promoter That Is Required for Its Osteoblast-selective Expression
J. Biol. Chem., April 28, 2000; 275(18): 13907 - 13917.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. M. Juriloff and M. J. Harris
Mouse models for neural tube closure defects
Hum. Mol. Genet., March 1, 2000; 9(6): 993 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Zerucha, T. Stuhmer, G. Hatch, B. K. Park, Q. Long, G. Yu, A. Gambarotta, J. R. Schultz, J. L. R. Rubenstein, and M. Ekker
A Highly Conserved Enhancer in the Dlx5/Dlx6 Intergenic Region is the Site of Cross-Regulatory Interactions between Dlx Genes in the Embryonic Forebrain
J. Neurosci., January 15, 2000; 20(2): 709 - 721.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Groves and M Bronner-Fraser
Competence, specification and commitment in otic placode induction
Development, January 8, 2000; 127(16): 3489 - 3499.
[Abstract] [PDF]

Home page
 DevelopmentHome page
B Kanzler, R. Foreman, P. Labosky, and M Mallo
BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest
Development, January 3, 2000; 127(5): 1095 - 1104.
[Abstract] [PDF]

Home page
 DevelopmentHome page
C. Ferguson, A. Tucker, and P. Sharpe
Temporospatial cell interactions regulating mandibular and maxillary arch patterning
Development, January 1, 2000; 127(2): 403 - 412.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Masuda, A. Sasaki, H. Shibuya, N. Ueno, K. Ikeda, and K. Watanabe
Dlxin-1, a Novel Protein That Binds Dlx5 and Regulates Its Transcriptional Function
J. Biol. Chem., February 9, 2001; 276(7): 5331 - 5338.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Blin-Wakkach, F. Lezot, S. Ghoul-Mazgar, D. Hotton, S. Monteiro, C. Teillaud, L. Pibouin, S. Orestes-Cardoso, P. Papagerakis, M. Macdougall, et al.
Endogenous Msx1 antisense transcript: In vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals
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