|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 18 4027-4037, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
P Casaccia-Bonnefil, RJ Hardy, KK Teng, JM Levine, A Koff and MV Chao
Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA. pcasacci@saturn.med. nyu.edu
In many tissues, progenitor cells permanently withdraw from the cell cycle prior to commitment towards a differentiated phenotype. In the oligodendrocyte lineage a counting mechanism has been proposed, linking the number of cell divisions to growth arrest and differentiation. A direct prediction of this model is that an increase in the number of cell divisions would result in a delayed onset of differentiation. Since the cell cycle inhibitor p27Kip1 is an essential component of the machinery leading to oligodendrocyte progenitor growth arrest, we examined the temporal relationship between cell cycle withdrawal and expression of late differentiation markers in vivo, in mice carrying a targeted deletion in the p27Kip1 gene. Using bromodeoxyuridine to label proliferating cells, quaking (QKI) to identify embryonic glial progenitors, NG2 to identify neonatal oligodendrocyte progenitors, and myelin basic protein to label differentiated oligodendrocytes, we found an increased number of proliferating QKI- and NG2-positive cells in germinal zones of p27Kip1(-/-) mice at the peak of gliogenesis. However, no delay was observed in these mice in the appearance of the late differentiation marker myelin basic protein in the developing corpus callosum and cerebellum. Significantly, a decrease in cyclin E levels was observed in the brain of p27Kip1 null mice coincident with oligodendrocyte growth arrest. We conclude that two distinct modalities of growth arrest occur in the oligodendrocyte lineage: a p27Kip1-dependent mechanism of growth arrest affecting proliferation in early phases of gliogenesis, and a p27Kip1-independent event leading to withdrawal from the cell cycle and differentiation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. P. Narayanan, A. I. Flores, F. Wang, and W. B. Macklin Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination J. Neurosci., May 27, 2009; 29(21): 6860 - 6870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jablonska, A. Aguirre, R. Vandenbosch, S. Belachew, C. Berthet, P. Kaldis, and V. Gallo Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone J. Cell Biol., December 17, 2007; 179(6): 1231 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, D. Tian, L. Ku, D. J. Osterhout, and Y. Feng The Selective RNA-binding Protein Quaking I (QKI) Is Necessary and Sufficient for Promoting Oligodendroglia Differentiation J. Biol. Chem., August 10, 2007; 282(32): 23553 - 23560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yeh, J. P. Miller, T. Gaur, T. D. Capellini, J. Nikolich-Zugich, C. de la Hoz, L. Selleri, T. G. Bromage, A. J. van Wijnen, G. S. Stein, et al. Cooperation between p27 and p107 during Endochondral Ossification Suggests a Genetic Pathway Controlled by p27 and p130 Mol. Cell. Biol., July 15, 2007; 27(14): 5161 - 5171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Dugas, A. Ibrahim, and B. A. Barres A Crucial Role for p57Kip2 in the Intracellular Timer that Controls Oligodendrocyte Differentiation J. Neurosci., June 6, 2007; 27(23): 6185 - 6196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhao, D. Tian, M. Xia, W. B. Macklin, and Y. Feng Rescuing qkv Dysmyelination by a Single Isoform of the Selective RNA-Binding Protein QKI. J. Neurosci., November 1, 2006; 26(44): 11278 - 11286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sohn, J. Natale, L.-J. Chew, S. Belachew, Y. Cheng, A. Aguirre, J. Lytle, B. Nait-Oumesmar, C. Kerninon, M. Kanai-Azuma, et al. Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J. Neurosci., September 20, 2006; 26(38): 9722 - 9735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Lee, F. Liu, and N. Segil A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development Development, August 1, 2006; 133(15): 2817 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tarui, T. Takahashi, R.S. Nowakowski, N.L. Hayes, P.G. Bhide, and V.S. Caviness Overexpression of p27Kip1, Probability of Cell Cycle Exit, and Laminar Destination of Neocortical Neurons Cereb Cortex, September 1, 2005; 15(9): 1343 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Park, J. Boyce, J. Shin, and B. Appel Oligodendrocyte Specification in Zebrafish Requires Notch-Regulated Cyclin-Dependent Kinase Inhibitor Function J. Neurosci., July 20, 2005; 25(29): 6836 - 6844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dasgupta and D. H. Gutmann Neurofibromin Regulates Neural Stem Cell Proliferation, Survival, and Astroglial Differentiation In Vitro and In Vivo J. Neurosci., June 8, 2005; 25(23): 5584 - 5594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shen, J. Li, and P. Casaccia-Bonnefil Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain J. Cell Biol., May 23, 2005; 169(4): 577 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chittka, J. C. Arevalo, M. Rodriguez-Guzman, P. Perez, M. V. Chao, and M. Sendtner The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E J. Cell Biol., March 29, 2004; 164(7): 985 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sell Mouse Models to Study the Interaction of Risk Factors for Human Liver Cancer Cancer Res., November 15, 2003; 63(22): 7553 - 7562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Marin-Husstege, M. Muggironi, A. Liu, and P. Casaccia-Bonnefil Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression J. Neurosci., December 1, 2002; 22(23): 10333 - 10345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Stevens and R. D. Fields Regulation of the Cell Cycle in Normal and Pathological Glia Neuroscientist, April 1, 2002; 8(2): 93 - 97. [Abstract] [PDF]
|
|
|
|
|
|
F. Doetsch, J. M.-G. Verdugo, I. Caille, A. Alvarez-Buylla, M. V. Chao, and P. Casaccia-Bonnefil Lack of the Cell-Cycle Inhibitor p27Kip1 Results in Selective Increase of Transit-Amplifying Cells for Adult Neurogenesis J. Neurosci., March 15, 2002; 22(6): 2255 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Carey, B. Li, and E. DiCicco-Bloom Pituitary Adenylate Cyclase Activating Polypeptide Anti-Mitogenic Signaling in Cerebral Cortical Progenitors Is Regulated by p57Kip2-Dependent CDK2 Activity J. Neurosci., March 1, 2002; 22(5): 1583 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kostic and R. Roy Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans Development, January 5, 2002; 129(9): 2155 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-E. Legrier, A. Ducray, A. Propper, M. Chao, and A. Kastner Cell Cycle Regulation during Mouse Olfactory Neurogenesis Cell Growth Differ., December 1, 2001; 12(12): 591 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Coskun and M. B. Luskin The Expression Pattern of the Cell Cycle Inhibitor p19INK4d by Progenitor Cells of the Rat Embryonic Telencephalon and Neonatal Anterior Subventricular Zone J. Neurosci., May 1, 2001; 21(9): 3092 - 3103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Ghiani and V. Gallo Inhibition of Cyclin E-Cyclin-Dependent Kinase 2 Complex Formation and Activity Is Associated with Cell Cycle Arrest and Withdrawal in Oligodendrocyte Progenitor Cells J. Neurosci., February 15, 2001; 21(4): 1274 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tikoo, G. Zanazzi, D. Shiffman, J. Salzer, and M. V. Chao Cell Cycle Control of Schwann Cell Proliferation: Role of Cyclin-Dependent Kinase-2 J. Neurosci., June 15, 2000; 20(12): 4627 - 4634. [Abstract] [Full Text] [PDF]
|
|
