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Development, Vol 126, Issue 18 4077-4086, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
W Hampe, J Urny, I Franke, SA Hoffmeister-Ullerich, D Herrmann, CM Petersen, J Lohmann and HC Schaller
Center for Molecular Neurobiology, University of Hamburg, Martinistr. 52, D-20246 Hamburg, Germany. hampe@uke.uni-hamburg.de
The neuropeptide head activator plays an important role for proliferation and determination of stem cells in hydra. By affinity chromatography a 200 kDa head-activator binding protein, HAB, was isolated from the multiheaded mutant of Chlorohydra viridissima. Partial amino acid sequences were used to clone the HAB cDNA which coded for a receptor with a unique alignment of extracellular modules, a transmembrane domain, and a short carboxy-terminal cytoplasmic tail. A mammalian HAB homologue with identical alignment of these modules is expressed early in brain development. Specific antibodies revealed the presence of HAB in hydra as a transmembrane receptor, but also as secreted protein, both capable of binding head activator. Secretion of HAB during regeneration and expression in regions of high determination potential hint at a role for HAB in regulating the concentration and range of action of head activator.
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