|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 18 4157-4164, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
JS Cameron, L Dryer and SE Dryer
Department of Biology, University of Houston, Houston, TX 77204-5513, USA.
The developmental expression of macroscopic Ca(2+)-activated K(+) currents in chick ciliary ganglion neurons is dependent on an avian ortholog of TGFbeta1, known as TGFbeta4, secreted from target tissues in the eye. Here we report that a different isoform, TGFbeta3, is also expressed in a target tissue of ciliary ganglion neurons. Application of TGFbeta3 inhibits the functional expression of whole-cell Ca(2+)-activated K(+) currents evoked by 12 hour treatment with either TGFbeta1 or beta-neuregulin-1 in ciliary ganglion neurons developing in vitro. TGFbeta3 had no effect on voltage-activated Ca(2+) currents. A neutralizing antiserum specific for TGFbeta3 potentiates stimulation of Ca(2+)-activated K(+) currents evoked by a target tissue (iris) extract in cultured ciliary ganglion neurons, indicating that TGFbeta3 is an inhibitory component of these extracts. Intraocular injection of TGFbeta3 causes a modest but significant inhibition of the expression of Ca(2+)-activated K(+) currents in ciliary ganglion neurons developing in vivo. Further, intraocular injection of a TGFbeta3-neutralizing antiserum stimulates expression of Ca(2+)-activated K(+) currents in ciliary ganglion neurons developing in vivo, indicating that endogenous TGFbeta3 regulates the functional expression of this current. The normal developmental expression of functional Ca(2+)-activated K(+) currents in ciliary ganglion neurons developing in vivo is therefore regulated by two different target-derived isoforms of TGFbeta, which produce opposing effects on the electrophysiological differentiation of these neurons.
This article has been cited by other articles:
|
|
 |
|
  K. Rimmer and A. A. Harper Developmental Changes in Electrophysiological Properties and Synaptic Transmission in Rat Intracardiac Ganglion Neurons J Neurophysiol, June 1, 2006; 95(6): 3543 - 3552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-S. Chae, K.-S. Oh, and S. E. Dryer Growth Factors Mobilize Multiple Pools of KCa Channels in Developing Parasympathetic Neurons: Role of ADP-Ribosylation Factors and Related Proteins J Neurophysiol, August 1, 2005; 94(2): 1597 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-S. Chae, M. Martin-Caraballo, M. Anderson, and S. E. Dryer Akt Activation Is Necessary for Growth Factor-Induced Trafficking of Functional KCa Channels in Developing Parasympathetic Neurons J Neurophysiol, March 1, 2005; 93(3): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Casavant, C. M. Colbert, and S. E. Dryer A-Current Expression is Regulated by Activity but not by Target Tissues in Developing Lumbar Motoneurons of the Chick Embryo J Neurophysiol, November 1, 2004; 92(5): 2644 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lhuillier and S. E. Dryer Developmental Regulation of Neuronal KCa Channels by TGFbeta 1: An Essential Role for PI3 Kinase Signaling and Membrane Insertion J Neurophysiol, August 1, 2002; 88(2): 954 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Y.-P. Ko, M. L. Ko, and S. E. Dryer Developmental Expression of Retinal Cone cGMP-Gated Channels: Evidence for Rapid Turnover and Trophic Regulation J. Neurosci., January 1, 2001; 21(1): 221 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Cameron and S. E. Dryer BK-Type KCa Channels in Two Parasympathetic Cell Types: Differences in Kinetic Properties and Developmental Expression J Neurophysiol, December 1, 2000; 84(6): 2767 - 2776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lhuillier and S. E. Dryer Developmental Regulation of Neuronal KCa Channels by TGFbeta 1: Transcriptional and Posttranscriptional Effects Mediated by Erk MAP Kinase J. Neurosci., August 1, 2000; 20(15): 5616 - 5622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Perillan, M. Chen, E. A. Potts, and J. M. Simard Transforming Growth Factor-beta 1 Regulates Kir2.3 Inward Rectifier K+ Channels via Phospholipase C and Protein Kinase C-delta in Reactive Astrocytes from Adult Rat Brain J. Biol. Chem., January 11, 2002; 277(3): 1974 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Cameron, L. Dryer, and S. E. Dryer beta -Neuregulin-1 is required for the in vivo development of functional Ca2+-activated K+ channels in parasympathetic neurons PNAS, February 27, 2001; 98(5): 2832 - 2836. [Abstract] [Full Text] [PDF]
|
|
