|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 19 4187-4192, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
RJ Schwartz and EN Olson
Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. eolson@hamon.swmed.edu
Heart formation in Drosophila is dependent on the homeobox gene tinman. The homeobox gene Nkx2-5 is closely related to tinman and is the earliest known marker for cardiogenesis in vertebrate embryos. Recent studies of cis-regulatory elements required for Nkx2-5 expression in the developing mouse heart have revealed an extraordinary array of independent cardiac enhancers, and associated negative regulatory elements, that direct transcription in distinct regions of the embryonic heart. These studies demonstrate the modularity in cardiac transcription, in which different regulatory elements respond to distinct sets of transcription factors to control gene expression in different compartments of the developing heart. We consider the potential mechanisms underlying such transcriptional complexity, its possible significance for cardiac function, and the implications for evolution of the multichambered heart.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Shirai, K. Imanaka-Yoshida, M. D. Schneider, R. J. Schwartz, and T. Morisaki T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgf{beta}2 expression and endocardial cushion formation PNAS, November 3, 2009; 106(44): 18604 - 18609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Niu, D. Iyer, S. J. Conway, J. F. Martin, K. Ivey, D. Srivastava, A. Nordheim, and R. J. Schwartz Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart PNAS, November 18, 2008; 105(46): 17824 - 17829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ai, X. Fu, J. Wang, M.-F. Lu, L. Chen, A. Baldini, W. H. Klein, and J. F. Martin Canonical Wnt signaling functions in second heart field to promote right ventricular growth PNAS, May 29, 2007; 104(22): 9319 - 9324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fukushige, T. M. Brodigan, L. A. Schriefer, R. H. Waterston, and M. Krause Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development Genes & Dev., December 15, 2006; 20(24): 3395 - 3406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Davidson, W. Shi, J. Beh, L. Christiaen, and M. Levine FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis Genes & Dev., October 1, 2006; 20(19): 2728 - 2738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Olson Gene regulatory networks in the evolution and development of the heart. Science, September 29, 2006; 313(5795): 1922 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chi, P. K. Chatterjee, W. Wilson III, S.-X. Zhang, F. J. DeMayo, and R. J. Schwartz Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules PNAS, September 20, 2005; 102(38): 13490 - 13495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rojas, S. De Val, A. B. Heidt, S.-M. Xu, J. Bristow, and B. L. Black Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element Development, August 1, 2005; 132(15): 3405 - 3417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Riazi, H. Lee, C. Hsu, and G. Van Arsdell CSX/Nkx2.5 Modulates Differentiation of Skeletal Myoblasts and Promotes Differentiation into Neuronal Cells in Vitro J. Biol. Chem., March 18, 2005; 280(11): 10716 - 10720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Hong, G.-H. Lin, C. J.-F. Lin, W.-p. Wang, C.-C. Lee, T.-L. Lin, and J.-L. Wu Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish Development, November 1, 2004; 131(21): 5417 - 5427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Lee, S. Evans, T. Y. Ruan, and A. B. Lassar SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer Development, October 1, 2004; 131(19): 4709 - 4723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development Development, August 15, 2004; 131(16): 3931 - 3942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ponticos, T. Partridge, C. M. Black, D. J. Abraham, and G. Bou-Gharios Regulation of Collagen Type I in Vascular Smooth Muscle Cells by Competition between Nkx2.5 and {delta}EF1/ZEB1 Mol. Cell. Biol., July 15, 2004; 24(14): 6151 - 6161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E.J Teunissen and M. F.A Bierhuizen Transcriptional control of myocardial connexins Cardiovasc Res, May 1, 2004; 62(2): 246 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Nelson, S. A. Duncan, and R. P. Misra Conserved Enhancer in the Serum Response Factor Promoter Controls Expression During Early Coronary Vasculogenesis Circ. Res., April 30, 2004; 94(8): 1059 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.-H. Feng, and R. J. Schwartz The Cardiac Determination Factor, Nkx2-5, Is Activated by Mutual Cofactors GATA-4 and Smad1/4 via a Novel Upstream Enhancer J. Biol. Chem., March 12, 2004; 279(11): 10659 - 10669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Gruber and J. A. Epstein Development Gone Awry: Congenital Heart Disease Circ. Res., February 20, 2004; 94(3): 273 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Kelly, M. Lemonnier, S. Zaffran, A. Munk, and M. E. Buckingham Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart J. Cell Sci., December 15, 2003; 116(24): 5005 - 5013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. McElhinney, E. Geiger, J. Blinder, D. Woodrow Benson, and E. Goldmuntz NKX2.5 mutations in patients with congenital heart disease J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1650 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. M. MOORMAN and V. M. CHRISTOFFELS Cardiac Chamber Formation: Development, Genes, and Evolution Physiol Rev, October 1, 2003; 83(4): 1223 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Olson and M. D. Schneider Sizing up the heart: development redux in disease Genes & Dev., August 15, 2003; 17(16): 1937 - 1956. [Full Text] [PDF]
|
|
|
|
|
|
P. E.M.H. Habets, A. F.M. Moorman, and V. M. Christoffels Regulatory modules in the developing heart Cardiovasc Res, May 1, 2003; 58(2): 246 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Solloway and R. P. Harvey Molecular pathways in myocardial development: a stem cell perspective Cardiovasc Res, May 1, 2003; 58(2): 264 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Schachat and M. M. Briggs Phylogenetic implications of the superfast myosin in extraocular muscles J. Exp. Biol., August 1, 2002; 205(15): 2189 - 2201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kodama, T. Hirotani, Y. Suzuki, S. Ogawa, and K. Yamazaki Cardiomyogenic Differentiation in Cardiac Myxoma Expressing Lineage-Specific Transcription Factors Am. J. Pathol., August 1, 2002; 161(2): 381 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, M. Puceat, C. Perez-Terzic, A. Mery, K. Nakamura, M. Michalak, K.-H. Krause, and M. E. Jaconi Calreticulin reveals a critical Ca2+ checkpoint in cardiac myofibrillogenesis J. Cell Biol., July 8, 2002; 158(1): 103 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Bruneau Transcriptional Regulation of Vertebrate Cardiac Morphogenesis Circ. Res., March 22, 2002; 90(5): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.M. SMALL and P.A. KRIEG Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 71 - 80. [Abstract] [PDF]
|
|
|
|
|
|
I. Manabe and G. K. Owens The Smooth Muscle Myosin Heavy Chain Gene Exhibits Smooth Muscle Subtype-selective Modular Regulation in Vivo J. Biol. Chem., October 12, 2001; 276(42): 39076 - 39087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Scholl, P. McLoughlin, E. Ehler, C. de Giovanni, and B. W. Schafer Dral Is a P53-Responsive Gene Whose Four and a Half Lim Domain Protein Product Induces Apoptosis J. Cell Biol., October 30, 2000; 151(3): 495 - 506. [Abstract] [Full Text] [PDF]
|
|
