spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tucker, A. S.
Right arrow Articles by Sharpe, P. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tucker, A. S.
Right arrow Articles by Sharpe, P. T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 126, Issue 2 221-228, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development

AS Tucker, A Al Khamis, CA Ferguson, I Bach, MG Rosenfeld and PT Sharpe
Department of Craniofacial Development, GKT Dental Institute, Kings College, Guy's Hospital, London SE1 9RT, UK.

Clim-2 (NLI, Lbd1) is one of two related mouse proteins that interact with Lim-domain homeoproteins. In the mouse, embryonic expression of Clim-2 is particularly pronounced in facial ectomesenchyme and limb bud mesenchyme in association with Lim genes, Lhx-6 and Lmx-1 respectively. We show that in common with both these Lim genes, Clim-2 expression is regulated by signals from overlying epithelium. In both the developing face and the limb buds we identify Fgf-8 as the likely candidate signalling molecule that regulates Clim-2 expression. We show that in the mandibular arch, as in the limb, Fgf-8 functions in combination with CD44, a cell surface binding protein, and that blocking CD44 binding results in inhibition of Fgf8-induced expression of Clim-2 and Lhx-6. Regulation of gene expression by Fgf8 in association with CD44 is thus conserved between limb and mandibular arch development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
K. E. Haworth, C. Healy, P. Morgan, and P. T. Sharpe
Regionalisation of early head ectoderm is regulated by endoderm and prepatterns the orofacial epithelium
Development, October 1, 2004; 131(19): 4797 - 4806.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. S. Tucker, R. P. Watson, L. A. Lettice, G. Yamada, and R. E. Hill
Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution
Development, March 15, 2004; 131(6): 1235 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. P. Smidt, S. M. Smits, H. Bouwmeester, F. P. T. Hamers, A. J. A. van der Linden, A. J. C. G. M. Hellemons, J. Graw, and J. P. H. Burbach
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
Development, March 1, 2004; 131(5): 1145 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Hu, R. S. Marcucio, and J. A. Helms
A zone of frontonasal ectoderm regulates patterning and growth in the face
Development, May 1, 2003; 130(9): 1749 - 1758.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
N. Trokovic, R. Trokovic, P. Mai, and J. Partanen
Fgfr1 regulates patterning of the pharyngeal region
Genes & Dev., January 1, 2003; 17(1): 141 - 153.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. U. Frank, L. K. Fotheringham, J. A. Brewer, L. J. Muglia, M. Tristani-Firouzi, M. R. Capecchi, and A. M. Moon
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome
Development, January 10, 2002; 129(19): 4591 - 4603.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Tucker, D. Headon, P Schneider, B. Ferguson, P Overbeek, J Tschopp, and P. Sharpe
Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis
Development, January 11, 2000; 127(21): 4691 - 4700.
[Abstract] [PDF]


© The Company of Biologists Ltd 1999