|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 20 4421-4430, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
A Sato, T Kojima, K Ui-Tei, Y Miyata and K Saigo
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
In Drosophila, two Frizzled proteins, Frizzled and Dfrizzled-2, have been reported to serve as receptors of Wingless. Here, we identified the third member of the Drosophila Frizzled family (Dfrizzled-3). In contrast to Dfrizzled-2, Dfrizzled-3 was transcriptionally upregulated by Wingless signaling. Although Dfrizzled-3 was capable of binding to Wingless in vitro, Wingless-dependent Armadillo/beta -catenin stabilization occurred much less effectively in Drosophila cells transfected with Dfrizzled-3 than in those with Dfrizzled-2. Flies lacking Dfrizzled-3 activity were viable and fertile, with few morphological defects. Genetic and immunochemical analysis indicated that the absence of Dfrizzled-3 activity suppresses the effects of hypomorphic wingless mutations such as failure of wing and antenna formation and restores target gene expression to the normal levels without change in wingless expression. Wingless signaling may thus be attenuated by Dfrizzled-3 at least in wingless hypomorphic mutants.
This article has been cited by other articles:
|
|
 |
|
  A. Sato and A. Tomlinson Dorsal-ventral midline signaling in the developing Drosophila eye Development, February 15, 2007; 134(4): 659 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaiswal, N. Agrawal, and P. Sinha Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila Development, March 1, 2006; 133(5): 925 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Linker, C. Lesbros, J. Gros, L. W. Burrus, A. Rawls, and C. Marcelle {beta}-Catenin-dependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis Development, September 1, 2005; 132(17): 3895 - 3905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Adachi-Yamada, T. Harumoto, K. Sakurai, R. Ueda, K. Saigo, M. B. O'Connor, and H. Nakato Wing-to-Leg Homeosis by Spineless Causes Apoptosis Regulated by Fish-lips, a Novel Leucine-Rich Repeat Transmembrane Protein Mol. Cell. Biol., April 15, 2005; 25(8): 3140 - 3150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Han, D. Yan, T. Y. Belenkaya, and X. Lin Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc Development, February 15, 2005; 132(4): 667 - 679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-m. Chen, W. Strapps, A. Tomlinson, and G. Struhl Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless PNAS, November 9, 2004; 101(45): 15961 - 15966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Cong, L. Schweizer, and H. Varmus Wnt signals across the plasma membrane to activate the {beta}-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP Development, October 15, 2004; 131(20): 5103 - 5115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Golan, A. Yaniv, A. Bafico, G. Liu, and A. Gazit The Human Frizzled 6 (HFz6) Acts as a Negative Regulator of the Canonical Wnt{middle dot}{beta}-Catenin Signaling Cascade J. Biol. Chem., April 9, 2004; 279(15): 14879 - 14888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Roman-Roman, D.-L. Shi, V. Stiot, E. Hay, B. Vayssiere, T. Garcia, R. Baron, and G. Rawadi Murine Frizzled-1 Behaves as an Antagonist of the Canonical Wnt/{beta}-Catenin Signaling J. Biol. Chem., February 13, 2004; 279(7): 5725 - 5733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nusse Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface Development, November 15, 2003; 130(22): 5297 - 5305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ishitani, S. Kishida, J. Hyodo-Miura, N. Ueno, J. Yasuda, M. Waterman, H. Shibuya, R. T. Moon, J. Ninomiya-Tsuji, and K. Matsumoto The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/{beta}-Catenin Signaling Mol. Cell. Biol., January 1, 2003; 23(1): 131 - 139. [Abstract] [Full Text]
|
|
|
|
|
|
C.-h. Wu and R. Nusse Ligand Receptor Interactions in the Wnt Signaling Pathway in Drosophila J. Biol. Chem., October 25, 2002; 277(44): 41762 - 41769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Baeg, X Lin, N Khare, S Baumgartner, and N Perrimon Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless Development, January 1, 2001; 128(1): 87 - 94. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Boutros, J. Mihaly, T. Bouwmeester, and M. Mlodzik Signaling Specificity by Frizzled Receptors in Drosophila Science, June 9, 2000; 288(5472): 1825 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Tsuji, A Sato, I Hiratani, M Taira, K Saigo, and T Kojima Requirements of Lim1, a Drosophila LIM-homeobox gene, for normal leg and antennal development Development, January 10, 2000; 127(20): 4315 - 4323. [Abstract] [PDF]
|
|
