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Development, Vol 126, Issue 20 4465-4475, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed

G Minowada, LA Jarvis, CL Chi, A Neubuser, X Sun, N Hacohen, MA Krasnow and GR Martin
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California, San Francisco, CA 94143-0452, USA.

The Drosophila sprouty gene encodes an antagonist of FGF and EGF signaling whose expression is induced by the signaling pathways that it inhibits. Here we describe a family of vertebrate Sprouty homologs and demonstrate that the regulatory relationship with FGF pathways has been conserved. In both mouse and chick embryos, Sprouty genes are expressed in intimate association with FGF signaling centers. Gain- and loss-of-function experiments demonstrate that FGF signaling induces Sprouty gene expression in various tissues. Sprouty overexpression obtained by infecting the prospective wing territory of the chick embryo with a retrovirus containing a mouse Sprouty gene causes a reduction in limb bud outgrowth and other effects consistent with reduced FGF signaling from the apical ectodermal ridge. At later stages of development in the infected limbs there was a dramatic reduction in skeletal element length due to an inhibition of chondrocyte differentiation. The results provide evidence that vertebrate Sprouty proteins function as FGF-induced feedback inhibitors, and suggest a possible role for Sprouty genes in the pathogenesis of specific human chondrodysplasias caused by activating mutations in Fgfr3.
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Promotion and Attenuation of FGF Signaling Through the Ras-MAPK Pathway
Sci. Signal., April 13, 2004; 2004(228): pe17 - pe17.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
A. Liu, J. Y. H. Li, C. Bromleigh, Z. Lao, L. A. Niswander, and A. L. Joyner
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors
Development, December 22, 2003; 130(25): 6175 - 6185.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Xiong, Q. Zhao, Z. Rong, G. Huang, Y. Huang, P. Chen, S. Zhang, L. Liu, and Z. Chang
hSef Inhibits PC-12 Cell Differentiation by Interfering with Ras-Mitogen-activated Protein Kinase MAPK Signaling
J. Biol. Chem., December 12, 2003; 278(50): 50273 - 50282.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
I. Gross, D. J. Morrison, D. P. Hyink, K. Georgas, M. A. English, M. Mericskay, S. Hosono, D. Sassoon, P. D. Wilson, M. Little, et al.
The Receptor Tyrosine Kinase Regulator Sprouty1 Is a Target of the Tumor Suppressor WT1 and Important for Kidney Development
J. Biol. Chem., October 17, 2003; 278(42): 41420 - 41430.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
L. B. Corson, Y. Yamanaka, K.-M. V. Lai, and J. Rossant
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
Development, October 1, 2003; 130(19): 4527 - 4537.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R.-B. Yang, C. K. D. Ng, S. M. Wasserman, L. G. Komuves, M. E. Gerritsen, and J. N. Topper
A Novel Interleukin-17 Receptor-like Protein Identified in Human Umbilical Vein Endothelial Cells Antagonizes Basic Fibroblast Growth Factor-induced Signaling
J. Biol. Chem., August 29, 2003; 278(35): 33232 - 33238.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
G. R. Guy, E. S. M. Wong, P. Yusoff, S. Chandramouli, T. L. Lo, J. Lim, and C. W. Fong
Sprouty: how does the branch manager work?
J. Cell Sci., August 1, 2003; 116(15): 3061 - 3068.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. L. Chi, S. Martinez, W. Wurst, and G. R. Martin
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
Development, June 15, 2003; 130(12): 2633 - 2644.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. Kovalenko, X. Yang, R. J. Nadeau, L. K. Harkins, and R. Friesel
Sef Inhibits Fibroblast Growth Factor Signaling by Inhibiting FGFR1 Tyrosine Phosphorylation and Subsequent ERK Activation
J. Biol. Chem., April 11, 2003; 278(16): 14087 - 14091.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
C. Liu, E. Nakamura, V. Knezevic, S. Hunter, K. Thompson, and S. Mackem
A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
Development, April 1, 2003; 130(7): 1327 - 1337.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
E. E. Storm, J. L. R. Rubenstein, and G. R. Martin
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
PNAS, February 18, 2003; 100(4): 1757 - 1762.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Y. Yigzaw, H. M. Poppleton, N. Sreejayan, A. Hassid, and T. B. Patel
Protein-tyrosine Phosphatase-1B (PTP1B) Mediates the Anti-migratory Actions of Sprouty
J. Biol. Chem., January 3, 2003; 278(1): 284 - 288.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
J. Lim, P. Yusoff, E. S. M. Wong, S. Chandramouli, D.-H. Lao, C. W. Fong, and G. R. Guy
The Cysteine-Rich Sprouty Translocation Domain Targets Mitogen-Activated Protein Kinase Inhibitory Proteins to Phosphatidylinositol 4,5-Bisphosphate in Plasma Membranes
Mol. Cell. Biol., November 15, 2002; 22(22): 7953 - 7966.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
K. Niederreither, J. Vermot, B. Schuhbaur, P. Chambon, and P. Dolle
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
Development, August 1, 2002; 129(15): 3563 - 3574.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. A. Whitsett, J. C. Clark, L. Picard, J. W. Tichelaar, S. E. Wert, N. Itoh, A.-K. T. Perl, and M. T. Stahlman
Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis
J. Biol. Chem., June 14, 2002; 277(25): 22743 - 22749.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
J. E. Egan, A. B. Hall, B. A. Yatsula, and D. Bar-Sagi
The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins
PNAS, April 30, 2002; 99(9): 6041 - 6046.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
A. Hoffmann, S. Czichos, C. Kaps, D. Bachner, H. Mayer, Y. Zilberman, G. Turgeman, G. Pelled, G. Gross, and D. Gazit
The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2
J. Cell Sci., February 15, 2002; 115(4): 769 - 781.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. Yusoff, D.-H. Lao, S. H. Ong, E. S. M. Wong, J. Lim, T. L. Lo, H. F. Leong, C. W. Fong, and G. R. Guy
Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf
J. Biol. Chem., January 25, 2002; 277(5): 3195 - 3201.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. D. del Corral, D. N. Breitkreuz, and K. G. Storey
Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling
Development, January 4, 2002; 129(7): 1681 - 1691.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
I. Gross, B. Bassit, M. Benezra, and J. D. Licht
Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation
J. Biol. Chem., November 30, 2001; 276(49): 46460 - 46468.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
M. Furthauer, F. Reifers, M. Brand, B. Thisse, and C. Thisse
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish
Development, June 15, 2001; 128(12): 2175 - 2186.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning
Genes & Dev., May 1, 2001; 15(9): 1152 - 1166.
[Abstract] [Full Text]

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 JCBHome page
M.-A. Impagnatiello, S. Weitzer, G. Gannon, A. Compagni, M. Cotten, and G. Christofori
Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells
J. Cell Biol., March 5, 2001; 152(5): 1087 - 1098.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
T. Iwata, L. Chen, C.-l. Li, D. A. Ovchinnikov, R. R. Behringer, C. A. Francomano, and C.-X. Deng
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
Hum. Mol. Genet., July 1, 2000; 9(11): 1603 - 1613.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
D. C. Goldman, G. R. Martin, and P. P. Tam
Fate and function of the ventral ectodermal ridge during mouse tail development
Development, May 15, 2000; 127(10): 2113 - 2123.
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 DevelopmentHome page
N Bertrand, F Medevielle, and F Pituello
FGF signalling controls the timing of Pax6 activation in the neural tube
Development, January 11, 2000; 127(22): 4837 - 4843.
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 Genes Dev.Home page
A. Trumpp, M. J. Depew, J. L.R. Rubenstein, J. M. Bishop, and G. R. Martin
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
Genes & Dev., December 1, 1999; 13(23): 3136 - 3148.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
A. Sasaki, T. Taketomi, T. Wakioka, R. Kato, and A. Yoshimura
Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation
J. Biol. Chem., September 21, 2001; 276(39): 36804 - 36808.
[Abstract] [Full Text] [PDF]


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