|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 21 4771-4783, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
JB Charrier, MA Teillet, F Lapointe and NM Le Douarin
Institut d'Embryologie Cellulaire et Moleculaire, Avenue de la Belle-Gabrielle, France. Nicole.Le-Douarin@infobiogen.fr.
Hensen's node, also called the chordoneural hinge in the tail bud, is a group of cells that constitutes the organizer of the avian embryo and that expresses the gene HNF-3(&bgr;). During gastrulation and neurulation, it undergoes a rostral-to-caudal movement as the embryo elongates. Labeling of Hensen's node by the quail-chick chimera system has shown that, while moving caudally, Hensen's node leaves in its wake not only the notochord but also the floor plate and a longitudinal strand of dorsal endodermal cells. In this work, we demonstrate that the node can be divided into functionally distinct subregions. Caudalward migration of the node depends on the presence of the most posterior region, which is closely apposed to the anterior portion of the primitive streak as defined by expression of the T-box gene Ch-Tbx6L. We call this region the axial-paraxial hinge because it corresponds to the junction of the presumptive midline axial structures (notochord and floor plate) and the paraxial mesoderm. We propose that the axial-paraxial hinge is the equivalent of the neuroenteric canal of other vertebrates such as Xenopus. Blocking the caudal movement of Hensen's node at the 5- to 6-somite stage by removing the axial-paraxial hinge deprives the embryo of midline structures caudal to the brachial level, but does not prevent formation of the neural tube and mesoderm located posteriorly. However, the whole embryonic region generated posterior to the level of Hensen's node arrest undergoes widespread apoptosis within the next 24 hours. Hensen's node-derived structures (notochord and floor plate) thus appear to produce maintenance factor(s) that ensures the survival and further development of adjacent tissues.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Wilson, I. Olivera-Martinez, and K. G. Storey Stem cells, signals and vertebrate body axis extension Development, May 15, 2009; 136(10): 1591 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Esterberg, J.-M. Delalande, and A. Fritz Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm Development, December 1, 2008; 135(23): 3891 - 3901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. McGrew, A. Sherman, S. G. Lillico, F. M. Ellard, P. A. Radcliffe, H. J. Gilhooley, K. A. Mitrophanous, N. Cambray, V. Wilson, and H. Sang Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity Development, July 1, 2008; 135(13): 2289 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kominami, C. Takagi, T. Kurata, A. Kitayama, M. Nozaki, T. Sawasaki, K. Kuida, Y. Endo, N. Manabe, N. Ueno, et al. The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways. Genes Cells, July 1, 2006; 11(7): 701 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takemoto, M. Uchikawa, Y. Kamachi, and H. Kondoh Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1 Development, January 15, 2006; 133(2): 297 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Akai, P. A. Halley, and K. G. Storey FGF-dependent Notch signaling maintains the spinal cord stem zone Genes & Dev., December 1, 2005; 19(23): 2877 - 2887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Delfino-Machin, J. S. Lunn, D. N. Breitkreuz, J. Akai, and K. G. Storey Specification and maintenance of the spinal cord stem zone Development, October 1, 2005; 132(19): 4273 - 4283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Thorpe, G. Weidinger, and R. T. Moon Wnt/{beta}-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish Development, April 15, 2005; 132(8): 1763 - 1772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakamaki, C. Takagi, K. Kominami, S.-i. Sakata, Y. Yaoita, H. Y. Kubota, M. Nozaki, S. Yonehara, and N. Ueno The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity Genes Cells, December 1, 2004; 9(12): 1249 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. BREDESEN, P. MEHLEN, and S. RABIZADEH Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction Physiol Rev, April 1, 2004; 84(2): 411 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mehlen and D. E. Bredesen Meeting Report: Cellular Dependence--Old Concept, New Mechanisms Sci. Signal., December 16, 2003; 2003 (213): pe55 - pe55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Alexandre and M. Wassef The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures Development, November 15, 2003; 130(22): 5331 - 5338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Thibert, M.-A. Teillet, F. Lapointe, L. Mazelin, N. M. Le Douarin, and P. Mehlen Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog Science, August 8, 2003; 301(5634): 843 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. Le Douarin, and M.-A. Teillet Dual origin of the floor plate in the avian embryo Development, March 12, 2003; 129(20): 4785 - 4796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cambray and V. Wilson Axial progenitors with extensive potency are localised to the mouse chordoneural hinge Development, March 12, 2003; 129(20): 4855 - 4866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Freitas, S. Rodrigues, J.-B. Charrier, M.-A. Teillet, and I. Palmeirim Evidence for medial/lateral specification and positional information within the presomitic mesoderm Development, December 15, 2001; 128(24): 5139 - 5147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-B. Charrier, F. Lapointe, N. M. L. Douarin, and M.-A. Teillet Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis Development, October 15, 2001; 128(20): 4011 - 4020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wei, W. Roberts, L. Wang, M. Yamada, S. Zhang, Z. Zhao, S. A. Rivkees, R. J. Schwartz, and K. Imanaka-Yoshida Rho kinases play an obligatory role in vertebrate embryonic organogenesis Development, August 1, 2001; 128(15): 2953 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lance-Jones, N. Omelchenko, A. Bailis, S. Lynch, and K. Sharma Hoxd10 induction and regionalization in the developing lumbosacral spinal cord Development, June 15, 2001; 128(12): 2255 - 2268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Groves and M Bronner-Fraser Competence, specification and commitment in otic placode induction Development, January 8, 2000; 127(16): 3489 - 3499. [Abstract] [PDF]
|
|
