Development, Vol 126, Issue 21 4895-4902, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

A requirement for neuropilin-1 in embryonic vessel formation

T Kawasaki, T Kitsukawa, Y Bekku, Y Matsuda, M Sanbo, T Yagi and H Fujisawa
Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan. fujisawa@bio.nagoya-u.ac.jp.

Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of nerve fibers, suggesting that neuropilin-1 mediates semaphorin-elicited signals and regulates nerve fiber guidance in embryogenesis. Neuropilin-1 is also expressed in endothelial cells and shown to bind vascular endothelial growth factor (VEGF), a potent regulator for vasculogenesis and angiogenesis. However, the roles of neuropilin-1 in vascular formation have been unclear. This paper reported that the neuropilin-1 mutant mouse embryos exhibited various types of vascular defects, including impairment in neural vascularization, agenesis and transposition of great vessels, insufficient aorticopulmonary truncus (persistent truncus arteriosus), and disorganized and insufficient development of vascular networks in the yolk sac. The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance.
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				P. Guo, L. Xu, S. Pan, R. A. Brekken, S.-T. Yang, G. B. Whitaker, M. Nagane, P. E. Thorpe, J. S. Rosenbaum, H.-J. Su Huang, et al. Vascular Endothelial Growth Factor Isoforms Display Distinct Activities in Promoting Tumor Angiogenesis at Different Anatomic Sites Cancer Res., December 1, 2001; 61(23): 8569 - 8577. [Abstract] [Full Text] [PDF]

				D. Moyon, L. Pardanaud, L. Yuan, C. Breant, and A. Eichmann Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo Development, September 1, 2001; 128(17): 3359 - 3370. [Abstract] [Full Text] [PDF]

				L. Feiner, A. L. Webber, C. B. Brown, M. M. Lu, L. Jia, P. Feinstein, P. Mombaerts, J. A. Epstein, and J. A. Raper Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption Development, August 15, 2001; 128(16): 3061 - 3070. [Abstract] [Full Text] [PDF]

				C. B. Brown, L. Feiner, M.-M. Lu, J. Li, X. Ma, A. L. Webber, L. Jia, J. A. Raper, and J. A. Epstein PlexinA2 and semaphorin signaling during cardiac neural crest development Development, August 15, 2001; 128(16): 3071 - 3080. [Abstract] [Full Text] [PDF]

				O. Marin, A. Yaron, A. Bagri, M. Tessier-Lavigne, and J. L. R. Rubenstein Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions Science, August 3, 2001; 293(5531): 872 - 875. [Abstract] [Full Text] [PDF]

				I. Zachary Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1375 - C1386. [Abstract] [Full Text] [PDF]

				A. Weisz, B. Koren, T. Cohen, G. Neufeld, T. Kleinberger, B. S. Lewis, and M. Y. Flugelman Increased Vascular Endothelial Growth Factor 165 Binding to Kinase Insert Domain-Containing Receptor After Infection of Human Endothelial Cells by Recombinant Adenovirus Encoding the Vegf165 Gene Circulation, April 10, 2001; 103(14): 1887 - 1892. [Abstract] [Full Text] [PDF]

				L. E. Benjamin Glucose, VEGF-A, and Diabetic Complications Am. J. Pathol., April 1, 2001; 158(4): 1181 - 1184. [Full Text] [PDF]