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Development, Vol 126, Issue 21 4895-4902, Copyright © 1999 by Company of Biologists


JOURNAL ARTICLES

A requirement for neuropilin-1 in embryonic vessel formation

T Kawasaki, T Kitsukawa, Y Bekku, Y Matsuda, M Sanbo, T Yagi and H Fujisawa
Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan. fujisawa@bio.nagoya-u.ac.jp.

Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of nerve fibers, suggesting that neuropilin-1 mediates semaphorin-elicited signals and regulates nerve fiber guidance in embryogenesis. Neuropilin-1 is also expressed in endothelial cells and shown to bind vascular endothelial growth factor (VEGF), a potent regulator for vasculogenesis and angiogenesis. However, the roles of neuropilin-1 in vascular formation have been unclear. This paper reported that the neuropilin-1 mutant mouse embryos exhibited various types of vascular defects, including impairment in neural vascularization, agenesis and transposition of great vessels, insufficient aorticopulmonary truncus (persistent truncus arteriosus), and disorganized and insufficient development of vascular networks in the yolk sac. The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance.
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Development Gone Awry: Congenital Heart Disease
Circ. Res., February 20, 2004; 94(3): 273 - 283.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
O. Kessler, N. Shraga-Heled, T. Lange, N. Gutmann-Raviv, E. Sabo, L. Baruch, M. Machluf, and G. Neufeld
Semaphorin-3F Is an Inhibitor of Tumor Angiogenesis
Cancer Res., February 1, 2004; 64(3): 1008 - 1015.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
F. le Noble, D. Moyon, L. Pardanaud, L. Yuan, V. Djonov, R. Matthijsen, C. Breant, V. Fleury, and A. Eichmann
Flow regulates arterial-venous differentiation in the chick embryo yolk sac
Development, January 15, 2004; 131(2): 361 - 375.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
L. Wang, H. Zeng, P. Wang, S. Soker, and D. Mukhopadhyay
Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration
J. Biol. Chem., December 5, 2003; 278(49): 48848 - 48860.
[Abstract] [Full Text] [PDF]


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Cardiovasc ResHome page
V. Compernolle, K. Brusselmans, D. Franco, A. Moorman, M. Dewerchin, D. Collen, and P. Carmeliet
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1{alpha}
Cardiovasc Res, December 1, 2003; 60(3): 569 - 579.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
W. Shoji, S. Isogai, M. Sato-Maeda, M. Obinata, and J. Y. Kuwada
Semaphorin3a1 regulates angioblast migration and vascular development in zebrafish embryos
Development, July 15, 2003; 130(14): 3227 - 3236.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
L. Yuan, D. Moyon, L. Pardanaud, C. Breant, M. J. Karkkainen, K. Alitalo, and A. Eichmann
Abnormal lymphatic vessel development in neuropilin 2 mutant mice
Development, March 12, 2003; 129(20): 4797 - 4806.
[Abstract] [Full Text] [PDF]


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BloodHome page
Y. Yamada, Y. Oike, H. Ogawa, Y. Ito, H. Fujisawa, T. Suda, and N. Takakura
Neuropilin-1 on hematopoietic cells as a source of vascular development
Blood, March 1, 2003; 101(5): 1801 - 1809.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
C. Ruhrberg, H. Gerhardt, M. Golding, R. Watson, S. Ioannidou, H. Fujisawa, C. Betsholtz, and D. T. Shima
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
Genes & Dev., October 15, 2002; 16(20): 2684 - 2698.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
P. Lee, K. Goishi, A. J. Davidson, R. Mannix, L. Zon, and M. Klagsbrun
Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish
PNAS, August 6, 2002; 99(16): 10470 - 10475.
[Abstract] [Full Text] [PDF]


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Physiol. Rev.Home page
L. Jussila and K. Alitalo
Vascular Growth Factors and Lymphangiogenesis
Physiol Rev, July 1, 2002; 82(3): 673 - 700.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
R. Mamluk, Z.'e. Gechtman, M. E. Kutcher, N. Gasiunas, J. Gallagher, and M. Klagsbrun
Neuropilin-1 Binds Vascular Endothelial Growth Factor 165, Placenta Growth Factor-2, and Heparin via Its b1b2 Domain
J. Biol. Chem., June 28, 2002; 277(27): 24818 - 24825.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
C. Gu, B. J. Limberg, G. B. Whitaker, B. Perman, D. J. Leahy, J. S. Rosenbaum, D. D. Ginty, and A. L. Kolodkin
Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165
J. Biol. Chem., May 10, 2002; 277(20): 18069 - 18076.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
S. Takashima, M. Kitakaze, M. Asakura, H. Asanuma, S. Sanada, F. Tashiro, H. Niwa, J.-i. Miyazaki, S. Hirota, Y. Kitamura, et al.
Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
PNAS, March 19, 2002; 99(6): 3657 - 3662.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
C. Liu, W. Liu, J. Palie, M. F. Lu, N. A. Brown, and J. F. Martin
Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions
Development, January 11, 2002; 129(21): 5081 - 5091.
[Abstract] [Full Text] [PDF]


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Am. J. Pathol.Home page
A. M. Matthies, Q. E. H. Low, M. W. Lingen, and L. A. DiPietro
Neuropilin-1 Participates in Wound Angiogenesis
Am. J. Pathol., January 1, 2002; 160(1): 289 - 296.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
P. Guo, L. Xu, S. Pan, R. A. Brekken, S.-T. Yang, G. B. Whitaker, M. Nagane, P. E. Thorpe, J. S. Rosenbaum, H.-J. Su Huang, et al.
Vascular Endothelial Growth Factor Isoforms Display Distinct Activities in Promoting Tumor Angiogenesis at Different Anatomic Sites
Cancer Res., December 1, 2001; 61(23): 8569 - 8577.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
D. Moyon, L. Pardanaud, L. Yuan, C. Breant, and A. Eichmann
Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo
Development, September 1, 2001; 128(17): 3359 - 3370.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
L. Feiner, A. L. Webber, C. B. Brown, M. M. Lu, L. Jia, P. Feinstein, P. Mombaerts, J. A. Epstein, and J. A. Raper
Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
Development, August 15, 2001; 128(16): 3061 - 3070.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
C. B. Brown, L. Feiner, M.-M. Lu, J. Li, X. Ma, A. L. Webber, L. Jia, J. A. Raper, and J. A. Epstein
PlexinA2 and semaphorin signaling during cardiac neural crest development
Development, August 15, 2001; 128(16): 3071 - 3080.
[Abstract] [Full Text] [PDF]


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ScienceHome page
O. Marin, A. Yaron, A. Bagri, M. Tessier-Lavigne, and J. L. R. Rubenstein
Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions
Science, August 3, 2001; 293(5531): 872 - 875.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
I. Zachary
Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1375 - C1386.
[Abstract] [Full Text] [PDF]


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CirculationHome page
A. Weisz, B. Koren, T. Cohen, G. Neufeld, T. Kleinberger, B. S. Lewis, and M. Y. Flugelman
Increased Vascular Endothelial Growth Factor 165 Binding to Kinase Insert Domain-Containing Receptor After Infection of Human Endothelial Cells by Recombinant Adenovirus Encoding the Vegf165 Gene
Circulation, April 10, 2001; 103(14): 1887 - 1892.
[Abstract] [Full Text] [PDF]


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Am. J. Pathol.Home page
L. E. Benjamin
Glucose, VEGF-A, and Diabetic Complications
Am. J. Pathol., April 1, 2001; 158(4): 1181 - 1184.
[Full Text] [PDF]




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