|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 21 4903-4911, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
D Clements, RV Friday and HR Woodland
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. hw@dna.bio.warwick.ac.uk.
mRNA encoding the T-box transcription factor VegT is located throughout the vegetal pole of the Xenopus egg and is believed to play an important part in endoderm and mesoderm formation. We find that VegT generates endoderm both by cell-autonomous action and by generating TGF-beta family signals, the latter being entirely responsible for its mesoderm-inducing activity. Signalling molecules induced cell-autonomously by VegT include derriere, Xnr4 and activin B. Xnr1 and Xnr2 are also induced, but primarily in a non-autonomous manner. All of these signalling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesoderm in the animal cap assay, and hence are good candidates both for the endogenous zygotic mesoderm-inducing signal and for reinforcing the vegetal expression of endoderm markers.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Souopgui, B. Rust,, J. Vanhomwegen, J. Heasman, K. A. Henningfeld, E. Bellefroid, and T. Pieler The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus Genes & Dev., September 1, 2008; 22(17): 2347 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Steiner, M. J. Engleka, Q. Lu, E. C. Piwarzyk, S. Yaklichkin, J. L. Lefebvre, J. W. Walters, L. Pineda-Salgado, P. A. Labosky, and D. S. Kessler FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development Development, December 15, 2006; 133(24): 4827 - 4838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Zamparini, T. Watts, C. E. Gardner, S. R. Tomlinson, G. I. Johnston, and J. M. Brickman Hex acts with {beta}-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal Development, September 15, 2006; 133(18): 3709 - 3722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Poulain, M. Furthauer, B. Thisse, C. Thisse, and T. Lepage Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling Development, June 1, 2006; 133(11): 2189 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sinner, P. Kirilenko, S. Rankin, E. Wei, L. Howard, M. Kofron, J. Heasman, H. R. Woodland, and A. M. Zorn Global analysis of the transcriptional network controlling Xenopus endoderm formation. Development, May 1, 2006; 133(10): 1955 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Afouda, A. Ciau-Uitz, and R. Patient GATA4, 5 and 6 mediate TGF{beta} maintenance of endodermal gene expression in Xenopus embryos Development, February 15, 2005; 132(4): 763 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Birsoy, L. Berg, P. H. Williams, J. C. Smith, C. C. Wylie, J. L. Christian, and J. Heasman XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGF{beta} proteins in Xenopus development Development, February 1, 2005; 132(3): 591 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Piepenburg, D. Grimmer, P. H. Williams, and J. C. Smith Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B Development, October 15, 2004; 131(20): 4977 - 4986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Wardle and J. C. Smith Refinement of gene expression patterns in the early Xenopus embryo Development, October 1, 2004; 131(19): 4687 - 4696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sinner, S. Rankin, M. Lee, and A. M. Zorn Sox17 and {beta}-catenin cooperate to regulate the transcription of endodermal genes Development, July 1, 2004; 131(13): 3069 - 3080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mathieu, K. Griffin, P. Herbomel, T. Dickmeis, U. Strahle, D. Kimelman, F. M. Rosa, and N. Peyrieras Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations Development, February 1, 2004; 131(3): 629 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Dougan, R. M. Warga, D. A. Kane, A. F. Schier, and W. S. Talbot The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm Development, May 1, 2003; 130(9): 1837 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. White, B. I. Sun, H. L. Sive, and J. C. Smith Direct and indirect regulation of derriere, a Xenopus mesoderm-inducing factor, by VegT Development, March 12, 2003; 129(20): 4867 - 4876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Amacher, B. W. Draper, B. R. Summers, and C. B. Kimmel The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate Development, March 9, 2003; 129(14): 3311 - 3323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O. Aoki, N. B. David, G. Minchiotti, L. Saint-Etienne, T. Dickmeis, G. M. Persico, U. Strahle, P. Mourrain, and F. M. Rosa Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation Development, March 3, 2003; 129(2): 275 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y.R. Stainier A glimpse into the molecular entrails of endoderm formation Genes & Dev., April 15, 2002; 16(8): 893 - 907. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Eimon and R. M. Harland Effects of heterodimerization and proteolytic processing on Derriere and Nodal activity: implications for mesoderm induction in Xenopus Development, January 7, 2002; 129(13): 3089 - 3103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. Bourillot, N. Garrett, and J. B. Gurdon A changing morphogen gradient is interpreted by continuous transduction flow Development, January 5, 2002; 129(9): 2167 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schohl and F. Fagotto {beta}-catenin, MAPK and Smad signaling during early Xenopus development Development, January 1, 2002; 129(1): 37 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Reiter, Y Kikuchi, and D. Stainier Multiple roles for Gata5 in zebrafish endoderm formation Development, January 1, 2001; 128(1): 125 - 135. [Abstract] [PDF]
|
|
|
|
|
|
J. Xanthos, M Kofron, C Wylie, and J Heasman Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis Development, January 1, 2001; 128(2): 167 - 180. [Abstract] [PDF]
|
|
|
|
|
|
O. Wessely and E. M. De Robertis The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation Development, May 15, 2000; 127(10): 2053 - 2062. [Abstract] [PDF]
|
|
|
|
|
|
Y. Kikuchi, L. A. Trinh, J. F. Reiter, J. Alexander, D. Yelon, and D. Y.R. Stainier The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors Genes & Dev., May 15, 2000; 14(10): 1279 - 1289. [Abstract] [Full Text]
|
|
|
|
|
|
S. Germain, M. Howell, G. M. Esslemont, and C. S. Hill Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif Genes & Dev., February 15, 2000; 14(4): 435 - 451. [Abstract] [Full Text]
|
|
|
|
|
|
S Takahashi, C Yokota, K Takano, K Tanegashima, Y Onuma, J Goto, and M Asashima Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center Development, January 12, 2000; 127(24): 5319 - 5329. [Abstract] [PDF]
|
|
|
|
|
|
S Faure, M. Lee, T Keller, P ten Dijke, and M Whitman Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development Development, January 7, 2000; 127(13): 2917 - 2931. [Abstract] [PDF]
|
|
|
|
|
|
K. Tremblay, P. Hoodless, E. Bikoff, and E. Robertson Formation of the definitive endoderm in mouse is a Smad2-dependent process Development, January 7, 2000; 127(14): 3079 - 3090. [Abstract] [PDF]
|
|
|
|
|
|
S. Osada, Y Saijoh, A Frisch, C. Yeo, H Adachi, M Watanabe, M Whitman, H Hamada, and C. Wright Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1 Development, January 6, 2000; 127(11): 2503 - 2514. [Abstract] [PDF]
|
|
|
|
|
|
R Vignali, L Poggi, F Madeddu, and G Barsacchi HNF1(beta) is required for mesoderm induction in the Xenopus embryo Development, January 4, 2000; 127(7): 1455 - 1465. [Abstract] [PDF]
|
|
|
|
|
|
K Gritsman, W. Talbot, and A. Schier Nodal signaling patterns the organizer Development, January 3, 2000; 127(5): 921 - 932. [Abstract] [PDF]
|
|
|
|
|
|
E Agius, M Oelgeschlager, O Wessely, C Kemp, and E. De Robertis Endodermal Nodal-related signals and mesoderm induction in Xenopus Development, January 3, 2000; 127(6): 1173 - 1183. [Abstract] [PDF]
|
|
|
|
|
|
C. Hyde and R. Old Regulation of the early expression of the Xenopus nodal-related 1 gene, Xnr1 Development, January 3, 2000; 127(6): 1221 - 1229. [Abstract] [PDF]
|
|
|
|
|
|
M Kofron, T Demel, J Xanthos, J Lohr, B Sun, H Sive, S Osada, C Wright, C Wylie, and J Heasman Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors Development, January 12, 1999; 126(24): 5759 - 5770. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Scherer and J. M. Graff Calmodulin Differentially Modulates Smad1 and Smad2 Signaling J. Biol. Chem., December 22, 2000; 275(52): 41430 - 41438. [Abstract] [Full Text] [PDF]
|
|
