|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 22 4977-4987, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
KA Barth, Y Kishimoto, KB Rohr, C Seydler, S Schulte-Merker and SW Wilson
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Bone morphogenetic proteins (Bmps) are key regulators of dorsoventral (DV) patterning. Within the ectoderm, Bmp activity has been shown to inhibit neural development, promote epidermal differentiation and influence the specification of dorsal neurons and neural crest. In this study, we examine the patterning of neural tissue in mutant zebrafish embryos with compromised Bmp signalling activity. We find that although Bmp activity does not influence anteroposterior (AP) patterning, it does affect DV patterning at all AP levels of the neural plate. Thus, we show that Bmp activity is required for specification of cell fates around the margin of the entire neural plate, including forebrain regions that do not form neural crest. Surprisingly, we find that Bmp activity is also required for patterning neurons at all DV levels of the CNS. In swirl/bmp2b(-) (swr(-)) embryos, laterally positioned sensory neurons are absent whereas more medial interneuron populations are hugely expanded. However, in somitabun(-) (sbn(-)) embryos, which probably retain higher residual Bmp activity, it is the sensory neurons and not the interneurons that are expanded. Conversely, in severely Bmp depleted embryos, both interneurons and sensory neurons are absent and it is the most medial neurons that are expanded. These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm.
This article has been cited by other articles:
|
|
 |
|
  G. Gossrau, J. Thiele, R. Konang, T. Schmandt, and O. Brustle Bone Morphogenetic Protein-Mediated Modulation of Lineage Diversification During Neural Differentiation of Embryonic Stem Cells Stem Cells, April 1, 2007; 25(4): 939 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Chen and D. M. Panchision Concise Review: Bone Morphogenetic Protein Pleiotropism in Neural Stem Cells and Their Derivatives--Alternative Pathways, Convergent Signals Stem Cells, January 1, 2007; 25(1): 63 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Reiter and W. C. Skarnes Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition Genes & Dev., January 1, 2006; 20(1): 22 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Reversade, H. Kuroda, H. Lee, A. Mays, and E. M. De Robertis Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos Development, August 1, 2005; 132(15): 3381 - 3392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gestri, M. Carl, I. Appolloni, S. W. Wilson, G. Barsacchi, and M. Andreazzoli Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression Development, May 15, 2005; 132(10): 2401 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Stern Neural induction: old problem, new findings, yet more questions Development, May 1, 2005; 132(9): 2007 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Offner, N. Duval, M. Jamrich, and B. Durand The pro-apoptotic activity of a vertebrate Bar-like homeobox gene plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells Development, April 15, 2005; 132(8): 1807 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Filippi, N. Tiso, G. Deflorian, E. Zecchin, M. Bortolussi, and F. Argenton The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord PNAS, March 22, 2005; 102(12): 4377 - 4382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, and M. Hibi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm Development, March 15, 2005; 132(6): 1375 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity Development, December 1, 2004; 131(23): 5923 - 5933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kudoh, M. L. Concha, C. Houart, I. B. Dawid, and S. W. Wilson Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains Development, August 1, 2004; 131(15): 3581 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Szeto and D. Kimelman Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation Development, August 1, 2004; 131(15): 3751 - 3760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Furthauer, J. Van Celst, C. Thisse, and B. Thisse Fgf signalling controls the dorsoventral patterning of the zebrafish embryo Development, June 15, 2004; 131(12): 2853 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Lewis, J. Bonner, M. Modrell, J. W. Ragland, R. T. Moon, R. I. Dorsky, and D. W. Raible Reiterated Wnt signaling during zebrafish neural crest development Development, March 15, 2004; 131(6): 1299 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, A. W. Helms, and J. E. Johnson Distinct activities of Msx1 and Msx3 in dorsal neural tube development Development, March 1, 2004; 131(5): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chandran, H. Kato, D. Gerreli, A. Compston, C. N. Svendsen, and N. D. Allen FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway Development, December 29, 2003; 130(26): 6599 - 6609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tribulo, M. J. Aybar, V. H. Nguyen, M. C. Mullins, and R. Mayor Regulation of Msx genes by a Bmp gradient is essential for neural crest specification Development, December 29, 2003; 130(26): 6441 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. del Barco Barrantes, G. Davidson, H.-J. Grone, H. Westphal, and C. Niehrs Dkk1 and noggin cooperate in mammalian head induction Genes & Dev., September 15, 2003; 17(18): 2239 - 2244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cau and S. W. Wilson Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis Development, June 1, 2003; 130(11): 2455 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Winkler, M. Schafer, J. Duschl, M. Schartl, and J.-N. Volff Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-Specific Gene Duplication Genome Res., June 1, 2003; 13(6): 1067 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, T. Yabe, C.-H. Kim, T. Hirata, H. Nojima, O. Muraoka, T. Hirano, and M. Hibi A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish Development, May 1, 2003; 130(9): 1853 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Burgess, G. Reim, W. Chen, N. Hopkins, and M. Brand The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis Development, March 4, 2003; 129(4): 905 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vogel-Hopker and H. Rohrer The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs) Development, March 4, 2003; 129(4): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Woda, J. Pastagia, M. Mercola, and K. B. Artinger Dlx proteins position the neural plate border and determine adjacent cell fates Development, March 2, 2003; 130(2): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Rusten, R. Cantera, F. C. Kafatos, and R. Barrio The role of TGF{beta} signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates Development, August 1, 2002; 129(15): 3575 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Yelick and T. F. Schilling MOLECULAR DISSECTION OF CRANIOFACIAL DEVELOPMENT USING ZEBRAFISH Crit. Rev. Oral. Biol. Med., July 1, 2002; 13(4): 308 - 322. [Abstract] [Full Text]
|
|
|
|
|
|
G. Lupo, W. A. Harris, G. Barsacchi, and R. Vignali Induction and patterning of the telencephalon in Xenopus laevis Development, January 12, 2002; 129(23): 5421 - 5436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Munoz-Sanjuan, E. Bell, C. R. Altmann, A. Vonica, and A. H. Brivanlou Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein Development, January 12, 2002; 129(23): 5529 - 5540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gregori, C. Proschel, M. Noble, and M. Mayer-Proschel The Tripotential Glial-Restricted Precursor (GRP) Cell and Glial Development in the Spinal Cord: Generation of Bipotential Oligodendrocyte-Type-2 Astrocyte Progenitor Cells and Dorsal-Ventral Differences in GRP Cell Function J. Neurosci., January 1, 2002; 22(1): 248 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kiecker and C. Niehrs A morphogen gradient of Wnt/{beta}-catenin signalling regulates anteroposterior neural patterning in Xenopus Development, November 1, 2001; 128(21): 4189 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Panchision, J. M. Pickel, L. Studer, S.-H. Lee, P. A. Turner, T. G. Hazel, and R. D.G. McKay Sequential actions of BMP receptors control neural precursor cell production and fate Genes & Dev., August 15, 2001; 15(16): 2094 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sasai, K. Mizuseki, and Y. Sasai Requirement of FoxD3-class signaling for neural crest determination in Xenopus Development, July 1, 2001; 128(13): 2525 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-P. Heisenberg, C. Houart, M. Take-uchi, G.-J. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. L. Concha, R. Geisler, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon Genes & Dev., June 1, 2001; 15(11): 1427 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Blader and U. Strahle Zebrafish developmental genetics and central nervous system development Hum. Mol. Genet., April 1, 2000; 9(6): 945 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Liem, T. Jessell, and J Briscoe Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites Development, January 11, 2000; 127(22): 4855 - 4866. [Abstract] [PDF]
|
|
|
|
|
|
O Kazanskaya, A Glinka, and C Niehrs The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning Development, January 11, 2000; 127(22): 4981 - 4992. [Abstract] [PDF]
|
|
|
|
|
|
K Fekany-Lee, E Gonzalez, V Miller-Bertoglio, and L Solnica-Krezel The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways Development, January 6, 2000; 127(11): 2333 - 2345. [Abstract] [PDF]
|
|
|
|
|
|
S Shanmugalingam, C Houart, A Picker, F Reifers, R Macdonald, A Barth, K Griffin, M Brand, and S. Wilson Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon Development, January 6, 2000; 127(12): 2549 - 2561. [Abstract] [PDF]
|
|
