|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 23 5319-5326, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
AP Newman, GZ Acton, E Hartwieg, HR Horvitz and PW Sternberg
Howard Hughes Medical Institute, Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA. anewman@bcm.tmc.edu
The Caenorhabditis elegans hermaphrodite egg-laying system comprises several tissues, including the uterus and vulva. lin-11 encodes a LIM domain transcription factor needed for certain vulval precursor cells to divide asymmetrically. Based on lin-11 expression studies and the lin-11 mutant phenotype, we find that lin-11 is also required for C. elegans uterine morphogenesis. Specifically, lin-11 is expressed in the ventral uterine intermediate precursor (pi) cells and their progeny (the utse and uv1 cells), which connect the uterus to the vulva. Like (pi) cell induction, the uterine lin-11 expression responds to the uterine anchor cell and the lin-12-encoded receptor. In wild type animals, the utse, which forms the planar process at the uterine-vulval interface, fuses with the anchor cell. We found that, in lin-11 mutants, utse differentiation was abnormal, the utse failed to fuse with the anchor cell and a functional uterine-vulval connection was not made. These findings indicate that lin-11 is essential for uterine-vulval morphogenesis.
This article has been cited by other articles:
|
|
 |
|
  K. S. Oommen and A. P. Newman Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development Development, November 15, 2007; 134(22): 3999 - 4009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Broday, I. Kolotuev, C. Didier, A. Bhoumik, B. P. Gupta, P. W. Sternberg, B. Podbilewicz, and Z. Ronai The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans Genes & Dev., October 1, 2004; 18(19): 2380 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. N. Cinar, K. L. Richards, K. S. Oommen, and A. P. Newman The EGL-13 SOX Domain Transcription Factor Affects the Uterine {pi} Cell Lineages in Caenorhabditis elegans Genetics, November 1, 2003; 165(3): 1623 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Gupta, M. Wang, and P. W. Sternberg The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development Development, June 15, 2003; 130(12): 2589 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jarriault and I. Greenwald Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans Genes & Dev., October 15, 2002; 16(20): 2713 - 2728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cameron, S. G. Clark, J. B. McDermott, E. Aamodt, and H. R. Horvitz PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans Development, January 4, 2002; 129(7): 1763 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Sarafi-Reinach, T. Melkman, O. Hobert, and P. Sengupta The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans Development, September 1, 2001; 128(17): 3269 - 3281. [Abstract] [Full Text] [PDF]
|
|
