|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 23 5387-5398, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
M Koga, M Take-uchi, T Tameishi and Y Ohshima
Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka, Japan.
KIN-8 in C. elegans is highly homologous to human ROR-1 and 2 receptor tyrosine kinases of unknown functions. These kinases belong to a new subfamily related to the Trk subfamily. A kin-8 promoter::gfp fusion gene was expressed in ASI and many other neurons as well as in pharyngeal and head muscles. A kin-8 deletion mutant was isolated and showed constitutive dauer larva formation (Daf-c) phenotype: about half of the F(1) progeny became dauer larvae when they were cultivated on an old lawn of E. coli as food. Among the cells expressing kin-8::gfp, only ASI sensory neurons are known to express DAF-7 TGF-(beta), a key molecule preventing dauer larva formation. In the kin-8 deletion mutant, expression of daf-7::gfp in ASI was greatly reduced, dye-filling in ASI was specifically lost and ASI sensory processes did not completely extend into the amphid pore. The Daf-c phenotype was suppressed by daf-7 cDNA expression or a daf-3 null mutation. ASI-directed expression of kin-8 cDNA under the daf-7 promoter or expression by a heat shock promoter rescued the dye-filling defect, but not the Daf-c phenotype, of the kin-8 mutant. These results show that the kin-8 mutation causes the Daf-c phenotype through reduction of the daf-7 gene expression and that KIN-8 function is cell-autonomous for the dye-filling in ASI. KIN-8 is required for the process development of ASI, and also involved in promotion of daf-7 expression through a physiological or developmental function.
This article has been cited by other articles:
|
|
 |
|
  A. Y. Zinovyeva, Y. Yamamoto, H. Sawa, and W. C. Forrester Complex Network of Wnt Signaling Regulates Neuronal Migrations During Caenorhabditis elegans Development Genetics, July 1, 2008; 179(3): 1357 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Green, T. Inoue, and P. W. Sternberg The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway Development, November 15, 2007; 134(22): 4053 - 4062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Murakami, K. Bessinger, J. Hellmann, and S. Murakami Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal in Caenorhabditis elegans J. Neurosci., November 23, 2005; 25(47): 10894 - 10904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Watanabe, Y. Nagamatsu, K. Gengyo-Ando, S. Mitani, and Y. Ohshima Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans Development, July 15, 2005; 132(14): 3175 - 3184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Paganoni and A. Ferreira Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2 J. Cell Sci., January 15, 2005; 118(2): 433 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Forrester, C. Kim, and G. Garriga The Caenorhabditis elegans Ror RTK CAM-1 Inhibits EGL-20/Wnt Signaling in Cell Migration Genetics, December 1, 2004; 168(4): 1951 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ailion and J. H. Thomas Isolation and Characterization of High-Temperature-Induced Dauer Formation Mutants in Caenorhabditis elegans Genetics, September 1, 2003; 165(1): 127 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hirose, Y. Nakano, Y. Nagamatsu, T. Misumi, H. Ohta, and Y. Ohshima Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C. elegans Development, March 15, 2003; 130(6): 1089 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hikasa, M. Shibata, I. Hiratani, and M. Taira The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling Development, March 13, 2003; 129(22): 5227 - 5239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ailion and J. H. Thomas Dauer Formation Induced by High Temperatures in Caenorhabditis elegans Genetics, November 1, 2000; 156(3): 1047 - 1067. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Daniels, M. Ailion, J. H. Thomas, and P. Sengupta egl-4 Acts Through a Transforming Growth Factor-{beta}/SMAD Pathway in Caenorhabditis elegans to Regulate Multiple Neuronal Circuits in Response to Sensory Cues Genetics, September 1, 2000; 156(1): 123 - 141. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Chen, B. Ong, and V. Bennett LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling J. Cell Biol., August 20, 2001; 154(4): 841 - 856. [Abstract] [Full Text] [PDF]
|
|
