|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 23 5453-5462, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
F Agnes, M Suzanne and S Noselli
Centre de Biologie du Developpement, UMR 5547, 31062 Toulouse cedex, France.
In Drosophila, the Jun-N-terminal Kinase-(JNK) signaling pathway is required for epithelial cell shape changes during dorsal closure of the embryo. In the absence of JNK pathway activity, as in the DJNKK/hemipterous (hep) mutant, the dorsolateral ectodermal cells fail both to elongate and move toward the dorsal midline, leading to dorsally open embryos. We show here that hep and the JNK pathway are required later in development, for correct morphogenesis of other epithelia, the imaginal discs. During metamorphosis, the imaginal discs undergo profound morphological changes, giving rise to the adult head and thoracic structures, including the cuticle and appendages. hep mutant pupae and pharate adults show severe defects in discs morphogenesis, especially in the fusion of the two lateral wing discs. We show that these defects are accompanied by a loss of expression of puckered (puc), a JNK phosphatase-encoding gene, in a subset of peripodial cells that ultimately delineates the margins of fusing discs. In further support of a role of puc in discs morphogenesis, pupal and adult hep phenotypes are suppressed by reducing puc function, indicative of a negative role of puc in disc morphogenesis. Furthermore, we show that the small GTPase Dcdc42, but not Drac1, is an activator of puc expression in a hep-dependent manner in imaginal discs. Altogether, these results demonstrate a new role for the JNK pathway in epithelial morphogenesis, and provide genetic evidence for a role of the peripodial membrane in disc morphogenesis. We discuss a general model whereby the JNK pathway regulates morphogenesis of epithelia with differentiated edges.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Nusinow, L. Greenberg, and V. Hatini Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium Development, September 15, 2008; 135(18): 3031 - 3041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lebreton, C. Faucher, D. L. Cribbs, and C. Benassayag Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster Development, July 1, 2008; 135(13): 2301 - 2309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshioka, O. Suyari, and M. Yamaguchi Transcription factor NF-Y is involved in regulation of the JNK pathway during Drosophila thorax development. Genes Cells, February 1, 2008; 13(2): 117 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Takatori, E. Geh, L. Chen, L. Zhang, J. Meller, and Y. Xia Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2 Development, January 1, 2008; 135(1): 23 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Peretz, A. Bakhrat, and U. Abdu Expression of the Drosophila melanogaster GADD45 Homolog (CG11086) Affects Egg Asymmetric Development That Is Mediated by the c-Jun N-Terminal Kinase Pathway Genetics, November 1, 2007; 177(3): 1691 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lee, B. G. Stultz, and D. A. Hursh The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development Development, April 1, 2007; 134(7): 1301 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Srivastava, J. C. Pastor-Pareja, T. Igaki, R. Pagliarini, and T. Xu Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion PNAS, February 20, 2007; 104(8): 2721 - 2726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Polaski, L. Whitney, B. W. Barker, and B. Stronach Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development Genetics, October 1, 2006; 174(2): 719 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Guichard, J. M. Park, B. Cruz-Moreno, M. Karin, and E. Bier From The Cover: Anthrax lethal factor and edema factor act on conserved targets in Drosophila PNAS, February 28, 2006; 103(9): 3244 - 3249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Giagtzoglou and H. J. Bellen Fighting anthrax with flies PNAS, February 28, 2006; 103(9): 3013 - 3014. [Full Text] [PDF]
|
|
|
|
|
|
R. Biswas, D. Stein, and E. R. Stanley Drosophila Dok is required for embryonic dorsal closure Development, January 15, 2006; 133(2): 217 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Miotto, T. Sagnier, H. Berenger, D. Bohmann, J. Pradel, and Y. Graba Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis Genes & Dev., January 1, 2006; 20(1): 101 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. McEwen and M. Peifer Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis Development, September 1, 2005; 132(17): 3935 - 3946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Pallavi and L. S. Shashidhara Signaling interactions between squamous and columnar epithelia of the Drosophila wing disc J. Cell Sci., August 1, 2005; 118(15): 3363 - 3370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Kadrmas, M. A. Smith, K. A. Clark, S. M. Pronovost, N. Muster, J. R. Yates III, and M. C. Beckerle The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 J. Cell Biol., December 20, 2004; 167(6): 1019 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bharathi, S. K. Pallavi, R. Bajpai, B. S. Emerald, and L. S. Shashidhara Genetic characterization of the Drosophila homologue of coronin J. Cell Sci., April 15, 2004; 117(10): 1911 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Baena-Lopez, J. C. Pastor-Pareja, and J. Resino Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs Development, December 29, 2003; 130(26): 6497 - 6506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Pallavi and L. S. Shashidhara Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs Development, October 15, 2003; 130(20): 4931 - 4941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Resino, P. Salama-Cohen, and A. Garcia-Bellido Determining the role of patterned cell proliferation in the shape and size of the Drosophila wing PNAS, May 28, 2002; 99(11): 7502 - 7507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Pena-Rangel, I. Rodriguez, and J. R. Riesgo-Escovar A Misexpression Study Examining Dorsal Thorax Formation in Drosophila melanogaster Genetics, March 1, 2002; 160(3): 1035 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ciapponi, D. B. Jackson, M. Mlodzik, and D. Bohmann Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites Genes & Dev., June 15, 2001; 15(12): 1540 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Dobens, E Martin-Blanco, A Martinez-Arias, F. Kafatos, and L. Raftery Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis Development, January 5, 2001; 128(10): 1845 - 1856. [Abstract] [PDF]
|
|
|
|
|
|
E. Martin-Blanco, J. C. Pastor-Pareja, and A. Garcia-Bellido From the Cover: JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila PNAS, July 5, 2000; 97(14): 7888 - 7893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U Weber, N Paricio, and M Mlodzik Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye Development, January 8, 2000; 127(16): 3619 - 3629. [Abstract] [PDF]
|
|
