|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 24 5533-5546, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
ZM Varga, J Wegner and M Westerfield
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. monte@uoneuro.uoregon.edu
A currently favored hypothesis postulates that a single field of cells in the neural plate forms bilateral retinas. To learn how retinal precursors segregate, we followed individual labeled neural plate cells in zebrafish. In the late gastrula, a single field of odd-paired-like-expressing cells contributed to both retinas, bordered posteriorly by diencephalic precursors expressing mariposa. Median mariposa-expressing cells moved anteriorly, separating the eyes, and formed ventral anterior diencephalon, the presumptive hypothalamus. In cyclops mutants, corresponding cells failed to move anteriorly, a ventral diencephalon never formed, and the eyes remained fused. Ablation of the region containing these cells induced cyclopia in wild types. Our results indicate that movement of a median subpopulation of diencephalic precursors separates retinal precursors into left and right eyes. Wild-type cyclops gene function is required for these morphogenetic movements.
This article has been cited by other articles:
|
|
 |
|
  S. J. England, G. B. Blanchard, L. Mahadevan, and R. J. Adams A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia Development, December 1, 2006; 133(23): 4613 - 4617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Lee, S.-F. Wu, L. M. Goering, and R. I. Dorsky Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis Development, November 15, 2006; 133(22): 4451 - 4461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rembold, F. Loosli, R. J. Adams, and J. Wittbrodt Individual cell migration serves as the driving force for optic vesicle evagination. Science, August 25, 2006; 313(5790): 1130 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ziv and Y. Gothilf Circadian time-keeping during early stages of development. PNAS, March 14, 2006; 103(11): 4146 - 4151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Kay, B. A. Link, and H. Baier Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina Development, June 1, 2005; 132(11): 2573 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dutta, J.-E. Dietrich, G. Aspock, R. D. Burdine, A. Schier, M. Westerfield, and Z. M. Varga pitx3 defines an equivalence domain for lens and anterior pituitary placode Development, April 1, 2005; 132(7): 1579 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kapsimali, L. Caneparo, C. Houart, and S. W. Wilson Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity Development, December 1, 2004; 131(23): 5923 - 5933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Herzog, C. Sonntag, S. von der Hardt, H. H. Roehl, Z. M. Varga, and M. Hammerschmidt Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis Development, August 1, 2004; 131(15): 3681 - 3692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirose, Z. M. Varga, H. Kondoh, and M. Furutani-Seiki Single cell lineage and regionalization of cell populations during Medaka neurulation Development, June 1, 2004; 131(11): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Holzschuh, G. Hauptmann, and W. Driever Genetic Analysis of the Roles of Hh, FGF8, and Nodal Signaling during Catecholaminergic System Development in the Zebrafish Brain J. Neurosci., July 2, 2003; 23(13): 5507 - 5519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Take-uchi, J. D. W. Clarke, and S. W. Wilson Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity Development, March 1, 2003; 130(5): 955 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, J. Shin, H.-C. Park, S.-Y. Yeo, S.-K. Hong, S. Han, M. Rhee, C.-H. Kim, A. B. Chitnis, and T.-L. Huh Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish Development, January 10, 2002; 129(19): 4443 - 4455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mathieu, A. Barth, F. M. Rosa, S. W. Wilson, and N. Peyrieras Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development Development, January 7, 2002; 129(13): 3055 - 3065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development Development, October 15, 2001; 128(20): 4021 - 4034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Loosli, S. Winkler, C. Burgtorf, E. Wurmbach, W. Ansorge, T. Henrich, C. Grabher, D. Arendt, M. Carl, A. Krone, et al. Medaka eyeless is the key factor linking retinal determination and eye growth Development, October 15, 2001; 128(20): 4035 - 4044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. M. Varga, A. Amores, K. E. Lewis, Y.-L. Yan, J. H. Postlethwait, J. S. Eisen, and M. Westerfield Zebrafish smoothened functions in ventral neural tube specification and axon tract formation Development, September 15, 2001; 128(18): 3497 - 3509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Shanmugalingam, C Houart, A Picker, F Reifers, R Macdonald, A Barth, K Griffin, M Brand, and S. Wilson Ace/Fgf8 is required for forebrain commissure formation and patterning of the telencephalon Development, January 6, 2000; 127(12): 2549 - 2561. [Abstract] [PDF]
|
|
|
|
|
|
S Winkler, F Loosli, T Henrich, Y Wakamatsu, and J Wittbrodt The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye Development, January 5, 2000; 127(9): 1911 - 1919. [Abstract] [PDF]
|
|
