|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 3 505-516, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, JL De la Pompa, K Furlonger, C Paige, C Hui, KD Fischer, H Kishimoto, T Iwatsubo, T Katada, JR Woodgett and JM Penninger
The Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, Suite 706, Toronto, Ontario M5G 2C1, Canada.
The stress signaling kinase SEK1/MKK4 is a direct activator of stress-activated protein kinases (SAPKs; also called Jun-N-terminal kinases, JNKs) in response to a variety of cellular stresses, such as changes in osmolarity, metabolic poisons, DNA damage, heat shock or inflammatory cytokines. We have disrupted the sek1 gene in mice using homologous recombination. Sek1(-/- )embryos display severe anemia and die between embryonic day 10.5 (E10.5) and E12.5. Haematopoiesis from yolk sac precursors and vasculogenesis are normal in sek1(-/- )embryos. However, hepatogenesis and liver formation were severely impaired in the mutant embryos and E11.5 and E12.5 sek1(-/- )embryos had greatly reduced numbers of parenchymal hepatocytes. Whereas formation of the primordial liver from the visceral endoderm appeared normal, sek1(-/-) liver cells underwent massive apoptosis. These results provide the first genetic link between stress-responsive kinases and organogenesis in mammals and indicate that SEK1 provides a crucial and specific survival signal for hepatocytes.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  W. ENGSTROM and M. GRANERUS Expression of JNK-interacting Protein JIP-1 and Insulin-like Growth Factor II in Wilms Tumour Cell Lines and Primary Wilms Tumours Anticancer Res, July 1, 2009; 29(7): 2467 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Robinson, O. Shalhav, K. Otto, T. Kawai, M. Gorospe, and C. W. Rinker-Schaeffer Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines Mol. Cancer Res., March 1, 2008; 6(3): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Takatori, E. Geh, L. Chen, L. Zhang, J. Meller, and Y. Xia Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2 Development, January 1, 2008; 135(1): 23 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, B. Nadarajah, A. C. Robinson, B. W. McColl, J.-W. Jin, F. Dajas-Bailador, R. P. Boot-Handford, and C. Tournier Targeted Deletion of the Mitogen-Activated Protein Kinase Kinase 4 Gene in the Nervous System Causes Severe Brain Developmental Defects and Premature Death Mol. Cell. Biol., November 15, 2007; 27(22): 7935 - 7946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Breitwieser, S. Lyons, A. M. Flenniken, G. Ashton, G. Bruder, M. Willington, G. Lacaud, V. Kouskoff, and N. Jones Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells Genes & Dev., August 15, 2007; 21(16): 2069 - 2082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sethi, K. S. Ahn, D. Xia, J. M. Kurie, and B. B. Aggarwal Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-{kappa}B Activation and NF-{kappa}B-Regulated Antiapoptotic Gene Products J. Immunol., August 1, 2007; 179(3): 1926 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Peng, L. Peng, Y. Fan, E. Zandi, H. G. Shertzer, and Y. Xia A Critical Role for I{kappa}B Kinase beta in Metallothionein-1 Expression and Protection against Arsenic Toxicity J. Biol. Chem., July 20, 2007; 282(29): 21487 - 21496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cui, S. Darmanin, M. Natsuisaka, T. Kondo, M. Asaka, M. Shindoh, F. Higashino, J. Hamuro, F. Okada, M. Kobayashi, et al. Enhanced Expression of Asparagine Synthetase under Glucose-Deprived Conditions Protects Pancreatic Cancer Cells from Apoptosis Induced by Glucose Deprivation and Cisplatin Cancer Res., April 1, 2007; 67(7): 3345 - 3355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xia, H. Srinivas, Y.-h. Ahn, G. Sethi, X. Sheng, W. K. A. Yung, Q. Xia, P. J. Chiao, H. Kim, P. H. Brown, et al. Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NF{kappa}B-dependent Pathway J. Biol. Chem., February 9, 2007; 282(6): 3507 - 3519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Sadler, K. N. Krahn, N. A. Gaur, and C. Ukomadu Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 PNAS, January 30, 2007; 104(5): 1570 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bonnesen, C. Orskov, S. Rasmussen, P. J. Holst, J. P. Christensen, K. W. Eriksen, K. Qvortrup, N. Odum, and T. Labuda MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver Blood, November 15, 2005; 106(10): 3396 - 3404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Wu and A. M. Bennett Essential Role for Mitogen-activated Protein (MAP) Kinase Phosphatase-1 in Stress-responsive MAP Kinase and Cell Survival Signaling J. Biol. Chem., April 22, 2005; 280(16): 16461 - 16466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chi, M. R. Sarkisian, P. Rakic, and R. A. Flavell Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development PNAS, March 8, 2005; 102(10): 3846 - 3851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Djavani, I. Topisirovic, J. C. Zapata, M. Sadowska, Y. Yang, J. Rodas, I. S. Lukashevich, C. W. Bogue, C. D. Pauza, K. L. B. Borden, et al. The Proline-Rich Homeodomain (PRH/HEX) Protein Is Down-Regulated in Liver during Infection with Lymphocytic Choriomeningitis Virus J. Virol., February 15, 2005; 79(4): 2461 - 2473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nishina, T. Wada, and T. Katada Physiological Roles of SAPK/JNK Signaling Pathway J. Biochem., August 1, 2004; 136(2): 123 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Hartner, C. Schmittwolf, A. Kispert, A. M. Muller, M. Higuchi, and P. H. Seeburg Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1 J. Biol. Chem., February 6, 2004; 279(6): 4894 - 4902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nishitai, N. Shimizu, T. Negishi, H. Kishimoto, K. Nakagawa, D. Kitagawa, T. Watanabe, H. Momose, S. Ohata, S. Tanemura, et al. Stress Induces Mitochondria-mediated Apoptosis Independent of SAPK/JNK Activation in Embryonic Stem Cells J. Biol. Chem., January 16, 2004; 279(3): 1621 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-H. Cha, K. S. Cho, J. H. Lee, M. Kim, E. Kim, J. Park, S. B. Lee, and J. Chung Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-{kappa}B-Dependent Signaling Pathways Mol. Cell. Biol., November 15, 2003; 23(22): 7982 - 7991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Terai, I. Sakaida, N. Yamamoto, K. Omori, T. Watanabe, S. Ohata, T. Katada, K. Miyamoto, K. Shinoda, H. Nishina, et al. An In Vivo Model for Monitoring Trans-Differentiation of Bone Marrow Cells into Functional Hepatocytes J. Biochem., October 1, 2003; 134(4): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kishimoto, K. Nakagawa, T. Watanabe, D. Kitagawa, H. Momose, J. Seo, G. Nishitai, N. Shimizu, S. Ohata, S. Tanemura, et al. Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells J. Biol. Chem., May 2, 2003; 278(19): 16595 - 16601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sanjo, K. Takeda, T. Tsujimura, J. Ninomiya-Tsuji, K. Matsumoto, and S. Akira TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling Mol. Cell. Biol., February 15, 2003; 23(4): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boldt, U. H. Weidle, and W. Kolch The role of MAPK pathways in the action of chemotherapeutic drugs Carcinogenesis, November 1, 2002; 23(11): 1831 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sasaki, T. Wada, H. Kishimoto, J. Irie-Sasaki, G. Matsumoto, T. Goto, Z. Yao, A. Wakeham, T. W. Mak, A. Suzuki, et al. The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor-Induced Proliferation in Hematopoietic Cells J. Exp. Med., September 17, 2001; 194(6): 757 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tournier, C. Dong, T. K. Turner, S. N. Jones, R. A. Flavell, and R. J. Davis MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines Genes & Dev., June 1, 2001; 15(11): 1419 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions Endocr. Rev., April 1, 2001; 22(2): 153 - 183. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. M. Kyriakis and J. Avruch Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation Physiol Rev, April 1, 2001; 81(2): 807 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Eichhorst, M. Müller, M. Li-Weber, H. Schulze-Bergkamen, P. Angel, and P. H. Krammer A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs Mol. Cell. Biol., October 15, 2000; 20(20): 7826 - 7837. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. Tian, Z. Zhang, and D. M. Cohen MAPK signaling and the kidney Am J Physiol Renal Physiol, October 1, 2000; 279(4): F593 - F604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A.C. Almeida, D. Ilic, Q. Han, C. R. Hauck, F. Jin, H. Kawakatsu, D. D. Schlaepfer, and C. H. Damsky Matrix Survival Signaling: From Fibronectin via Focal Adhesion Kinase to C-Jun Nh2-Terminal Kinase J. Cell Biol., May 1, 2000; 149(3): 741 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kelkar, S. Gupta, M. Dickens, and R. J. Davis Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 Mol. Cell. Biol., February 1, 2000; 20(3): 1030 - 1043. [Abstract] [Full Text]
|
|
|
|
|
|
J. Martinez Barbera, M Clements, P Thomas, T Rodriguez, D Meloy, D Kioussis, and R. Beddington The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation Development, January 6, 2000; 127(11): 2433 - 2445. [Abstract] [PDF]
|
|
|
|
|
|
J. Yasuda, A. J. Whitmarsh, J. Cavanagh, M. Sharma, and R. J. Davis The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins Mol. Cell. Biol., October 1, 1999; 19(10): 7245 - 7254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Rosie Xing and R. Kolesnick Stress signaling of apoptosis via ceramide and c-jun kinase Innate Immunity, August 1, 1999; 5(4): 216 - 221. [Abstract] [PDF]
|
|
|
|
|
|
M. Karandikar, S. Xu, and M. H. Cobb MEKK1 Binds Raf-1 and the ERK2 Cascade Components J. Biol. Chem., December 15, 2000; 275(51): 40120 - 40127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diao, A. A. Khine, F. Sarangi, E. Hsu, C. Iorio, L. A. Tibbles, J. R. Woodgett, J. Penninger, and C. D. Richardson X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway J. Biol. Chem., March 9, 2001; 276(11): 8328 - 8340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wada, K. Nakagawa, T. Watanabe, G. Nishitai, J. Seo, H. Kishimoto, D. Kitagawa, T. Sasaki, J. M. Penninger, H. Nishina, et al. Impaired Synergistic Activation of Stress-activated Protein Kinase SAPK/JNK in Mouse Embryonic Stem Cells Lacking SEK1/MKK4. DIFFERENT CONTRIBUTION OF SEK2/MKK7 ISOFORMS TO THE SYNERGISTIC ACTIVATION J. Biol. Chem., August 10, 2001; 276(33): 30892 - 30897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morita, T. Naka, Y. Kawazoe, M. Fujimoto, M. Narazaki, R. Nakagawa, H. Fukuyama, S. Nagata, and T. Kishimoto Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha -induced cell death in fibroblasts PNAS, May 9, 2000; 97(10): 5405 - 5410. [Abstract] [Full Text] [PDF]
|
|
