spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grens, A.
Right arrow Articles by Fujisawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grens, A.
Right arrow Articles by Fujisawa, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 126, Issue 3 517-524, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra

A Grens, H Shimizu, SA Hoffmeister, HR Bode and T Fujisawa
Department of Developmental and Cell Biology, University of California, Irvine, California 92697-2300, USA.

Signaling molecules affecting patterning processes are usually proteins and rarely peptides. Two novel peptides, pedibin and Hym-346, that are closely related to one another have been isolated from Hydra vulgaris and Hydra magnipapillata. Several experiments indicate that both cause a reduction in the positional value gradient, the principle patterning process governing the maintenance of form in the adult hydra. The peptides cause an increase in the rate of foot regeneration following bisection of the body column. Treatment of animals with either peptide for an extended period of time resulted in an apical extension of the range of expression of CnNk-2 along the body column. Such an extension is correlated with a decrease in positional value. Transplantation of tissue treated with Hym-346 results in an increase in the fraction forming feet, and aggregates derived from Hym-346 tissue form more feet and fewer heads. The latter two experiments provide a direct measure of the lowering of positional value in the treated tissue. These results suggest that peptides play signaling roles in patterning processes in cnidaria and, plausibly, in more complex metazoans as well.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
T. Takahashi, M. Hatta, S. Yum, L. Gee, M. Ohtani, T. Fujisawa, and H. R. Bode
Hym-301, a novel peptide, regulates the number of tentacles formed in hydra
Development, May 1, 2005; 132(9): 2225 - 2234.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Shimizu, X. Zhang, J. Zhang, A. Leontovich, K. Fei, L. Yan, and M. P. Sarras Jr.
Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases
Development, March 5, 2003; 129(6): 1521 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N Harafuji, T Takahashi, M Hatta, H Tezuka, F Morishita, O Matsushima, and T Fujisawa
Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323
Development, January 2, 2001; 128(3): 437 - 446.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J. U. Lohmann and T. C.G. Bosch
The novel peptide HEADY specifies apical fate in a simple radially symmetric metazoan
Genes & Dev., November 1, 2000; 14(21): 2771 - 2777.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
R Deutzmann, S Fowler, X Zhang, K Boone, S Dexter, R. Boot-Handford, R Rachel, and M. Sarras
Molecular, biochemical and functional analysis of a novel and developmentally important fibrillar collagen (Hcol-I) in hydra
Development, January 11, 2000; 127(21): 4669 - 4680.
[Abstract] [PDF]

Home page
 DevelopmentHome page
T Takahashi, O Koizumi, Y Ariura, A Romanovitch, T. Bosch, Y Kobayakawa, S Mohri, H. Bode, S Yum, M Hatta, et al.
A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra
Development, January 3, 2000; 127(5): 997 - 1005.
[Abstract] [PDF]

Home page
 DevelopmentHome page
A. Leontovich, J Zhang, K Shimokawa, H Nagase, and M. Sarras
A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process
Development, January 2, 2000; 127(4): 907 - 920.
[Abstract] [PDF]

Home page
 DevelopmentHome page
W Hampe, J Urny, I Franke, S. Hoffmeister-Ullerich, D Herrmann, C. Petersen, J Lohmann, and H. Schaller
A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form
Development, January 9, 1999; 126(18): 4077 - 4086.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
S. J. Fowler, S. Jose, X. Zhang, R. Deutzmann, M. P. Sarras Jr., and R. P. Boot-Handford
Characterization of Hydra Type IV Collagen. TYPE IV COLLAGEN IS ESSENTIAL FOR HEAD REGENERATION AND ITS EXPRESSION IS UP-REGULATED UPON EXPOSURE TO GLUCOSE
J. Biol. Chem., December 8, 2000; 275(50): 39589 - 39599.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1999