|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 3 555-566, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
MJ Belliveau and CL Cepko
Program in Neuroscience, Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
The seven major classes of cells of the vertebrate neural retina are generated from a pool of multipotent progenitor cells. Recent studies suggest a model of retinal development in which both the progenitor cells and the environment change over time (Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M. and Ezzeddine, D. (1996). Proc. Natl. Acad. Sci. USA 93, 589-595). We have utilized a reaggregate culture system to test this model. A labeled population of progenitors from the embryonic rat retina were cultured with an excess of postnatal retinal cells and then assayed for their cell fate choices. We found that the postnatal environment had at least two signals that affected the embryonic cells' choice of fate; one signal inhibited the production of amacrine cells and a second affected the production of cone cells. No increase in cell types generated postnatally was observed. The source of the inhibitor of the amacrine cell fate appeared to be previously generated amacrine cells, suggesting that amacrine cell number is controlled by feedback inhibition. The progenitor cell lost its ability to be inhibited for production of an amacrine cell as it entered M phase of the cell cycle. We suggest that postmitotic cells influence progenitor cell fate decisions, but that they do so in a manner restricted by the intrinsic biases of progenitor cells.
This article has been cited by other articles:
|
|
 |
|
  K. Durr, J. Holzschuh, A. Filippi, A.-K. Ettl, S. Ryu, I. T. Shepherd, and W. Driever Differential Roles of Transcriptional Mediator Complex Subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 During Zebrafish Retinal Development Genetics, October 1, 2006; 174(2): 693 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Jadhav, H. A. Mason, and C. L. Cepko Notch 1 inhibits photoreceptor production in the developing mammalian retina Development, March 1, 2006; 133(5): 913 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Cleary and C. Q. Doe Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window. Genes & Dev., February 15, 2006; 20(4): 429 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kim, H.-H. Wu, A. D. Lander, K. M. Lyons, M. M. Matzuk, and A. L. Calof GDF11 Controls the Timing of Progenitor Cell Competence in Developing Retina Science, June 24, 2005; 308(5730): 1927 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Tyler, L. H. Carney, and D. A. Cameron Control of Cellular Pattern Formation in the Vertebrate Inner Retina by Homotypic Regulation of Cell-Fate Decisions J. Neurosci., May 4, 2005; 25(18): 4565 - 4576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. GAMM, A. D. NELSON, and C. N. SVENDSEN Human Retinal Progenitor Cells Grown as Neurospheres Demonstrate Time-Dependent Changes in Neuronal and Glial Cell Fate Potential Ann. N.Y. Acad. Sci., May 1, 2005; 1049(1): 107 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang, Z. Zhang, C. Zhang, L. Zhang, A. Robin, Y. Wang, M. Lu, and M. Chopp Stroke Transiently Increases Subventricular Zone Cell Division from Asymmetric to Symmetric and Increases Neuronal Differentiation in the Adult Rat J. Neurosci., June 23, 2004; 24(25): 5810 - 5815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Canzoniere, S. Farioli-Vecchioli, F. Conti, M. T. Ciotti, A. M. Tata, G. Augusti-Tocco, E. Mattei, M. K. Lakshmana, V. Krizhanovsky, S. A. Reeves, et al. Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1 J. Neurosci., March 31, 2004; 24(13): 3355 - 3369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brownlee Inaugural Article: Biography of Constance L. Cepko PNAS, January 6, 2004; 101(1): 14 - 15. [Full Text] [PDF]
|
|
|
|
|
|
C. Hanashima, S. C. Li, L. Shen, E. Lai, and G. Fishell Foxg1 Suppresses Early Cortical Cell Fate Science, January 2, 2004; 303(5654): 56 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Cronin, A. B. Ryan, E. M. Talley, and H. Scrable Tyrosinase Expression during Neuroblast Divisions Affects Later Pathfinding by Retinal Ganglion Cells J. Neurosci., December 17, 2003; 23(37): 11692 - 11697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. James, A. V. Das, S. Bhattacharya, D. M. Chacko, X. Zhao, and I. Ahmad In Vitro Generation of Early-Born Neurons from Late Retinal Progenitors J. Neurosci., September 10, 2003; 23(23): 8193 - 8203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Viczian, R. Vignali, M. E. Zuber, G. Barsacchi, and W. A. Harris XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina Development, April 1, 2003; 130(7): 1281 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Brody and W. F. Odenwald Cellular diversity in the developing nervous system: a temporal view from Drosophila Development, March 10, 2003; 129(16): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kubo, M. Takeichi, and S. Nakagawa Wnt2b controls retinal cell differentiation at the ciliary marginal zone Development, February 1, 2003; 130(3): 587 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Brown, S. Patel, J. Brzezinski, and T. Glaser Math5 is required for retinal ganglion cell and optic nerve formation Development, July 1, 2001; 128(13): 2497 - 2508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Dyer and C. L. Cepko p27Kip1 and p57Kip2 Regulate Proliferation in Distinct Retinal Progenitor Cell Populations J. Neurosci., June 15, 2001; 21(12): 4259 - 4271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang and X. Yang Regulation of retinal ganglion cell production by Sonic hedgehog Development, January 3, 2001; 128(6): 943 - 957. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Wang, B. S. Kim, K. Ding, H. Wang, D. Sun, R. L. Johnson, W. H. Klein, and L. Gan Requirement for math5 in the development of retinal ganglion cells Genes & Dev., January 1, 2001; 15(1): 24 - 29. [Abstract] [Full Text]
|
|
|
|
|
|
M Gonzalez-Hoyuela, J. Barbas, and A Rodriguez-Tebar The autoregulation of retinal ganglion cell number Development, January 1, 2001; 128(1): 117 - 124. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Di Polo, L. Cheng, G. M. Bray, and A. J. Aguayo Colocalization of TrkB and Brain-Derived Neurotrophic Factor Proteins in Green-Red-Sensitive Cone Outer Segments Invest. Ophthalmol. Vis. Sci., November 1, 2000; 41(12): 4014 - 4021. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. Belliveau, T. L. Young, and C. L. Cepko Late Retinal Progenitor Cells Show Intrinsic Limitations in the Production of Cell Types and the Kinetics of Opsin Synthesis J. Neurosci., March 15, 2000; 20(6): 2247 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Desai and S. McConnell Progressive restriction in fate potential by neural progenitors during cerebral cortical development Development, January 7, 2000; 127(13): 2863 - 2872. [Abstract] [PDF]
|
|
|
|
 |
|
 P. K. Swain, D. Hicks, A. J. Mears, I. J. Apel, J. E. Smith, S. K. John, A. Hendrickson, A. H. Milam, and A. Swaroop Multiple Phosphorylated Isoforms of NRL Are Expressed in Rod Photoreceptors J. Biol. Chem., September 21, 2001; 276(39): 36824 - 36830. [Abstract] [Full Text] [PDF]
|
|
