|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 4 629-638, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
Y Arimatsu, M Ishida, K Takiguchi-Hayashi and Y Uratani
Mitsubishi Kasei Institute of Life Sciences, Machida-shi, Tokyo 194-8511, Japan. yasu@libra.ls.m-kagaku.co.jp
Neurons expressing latexin, a carboxypeptidase A inhibitor, are restricted to lateral areas in the cerebral cortex of adult and early postnatal rats. To address the precise timing of cortical regional specification at the cellular level, we monitored latexin expression in developing cortical cells under specific conditions in vitro. Individual cortical cells were labeled with 5-bromo-2'-deoxyuridine in vivo, dissociated and exposed to a defined new environment in a monolayer or a reaggregated-cell culture system. While a substantial fraction of early progenitor cells derived from the lateral cerebral wall became latexin-expressing neurons in both systems, far fewer progenitors from dorsal cortex did so under the same environmental conditions, indicating early establishment of cortical regional specification at the progenitor cell level. Furthermore, it was shown that the probability for postmitotic cells within lateral cortex to become latexin-expressing neurons was influenced by temporally regulated regional environmental signals. These findings suggest that developing cortical cells are progressively specified for a regional molecular phenotype during both their proliferative and postmitotic periods.
This article has been cited by other articles:
|
|
 |
|
  W. Bai, M. Ishida, M. Okabe, and Y. Arimatsu Role of the Protomap and Target-derived Signals in the Development of Intrahemispheric Connections Cereb Cortex, January 1, 2006; 16(1): 124 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takiguchi-Hayashi, M. Sekiguchi, S. Ashigaki, M. Takamatsu, H. Hasegawa, R. Suzuki-Migishima, M. Yokoyama, S. Nakanishi, and Y. Tanabe Generation of Reelin-Positive Marginal Zone Cells from the Caudomedial Wall of Telencephalic Vesicles J. Neurosci., March 3, 2004; 24(9): 2286 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Wada, M. Inagawa-Ogashiwa, S. Shimizu, S. Yasumoto, and N. Hashimoto Generation of different fates from multipotent muscle stem cells Development, March 8, 2003; 129(12): 2987 - 2995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Korada, W. Zheng, C. Basilico, M. L. Schwartz, and F. M. Vaccarino Fibroblast Growth Factor 2 Is Necessary for the Growth of Glutamate Projection Neurons in the Anterior Neocortex J. Neurosci., February 1, 2002; 22(3): 863 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Polleux, C. Dehay, A. Goffinet, and H. Kennedy Pre- and Post-mitotic Events Contribute to the Progressive Acquisition of Area-specific Connectional Fate in the Neocortex Cereb Cortex, November 1, 2001; 11(11): 1027 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tole and E. A. Grove Detailed Field Pattern Is Intrinsic to the Embryonic Mouse Hippocampus Early in Neurogenesis J. Neurosci., March 1, 2001; 21(5): 1580 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fode, Q. Ma, S. Casarosa, S.-L. Ang, D. J. Anderson, and F. Guillemot A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons Genes & Dev., January 1, 2000; 14(1): 67 - 80. [Abstract] [Full Text]
|
|
|
|
|
|
J. L.R. Rubenstein, S. Anderson, L. Shi, E. Miyashita-Lin, A. Bulfone, and R. Hevner Genetic Control of Cortical Regionalization and Connectivity Cereb Cortex, September 1, 1999; 9(6): 524 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Eagleson and P. Levitt Complex Signaling Responsible for Molecular Regionalization of the Cerebral Cortex Cereb Cortex, September 1, 1999; 9(6): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arimatsu, M. Ishida, M. Sato, and M. Kojima Corticocortical Associative Neurons Expressing Latexin: Specific Cortical Connectivity Formed In Vivo and In Vitro Cereb Cortex, September 1, 1999; 9(6): 569 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gitton, M. Cohen-Tannoudji, and M. Wassef Role of Thalamic Axons in the Expression of H-2Z1, a Mouse Somatosensory Cortex Specific Marker Cereb Cortex, September 1, 1999; 9(6): 611 - 620. [Abstract] [Full Text] [PDF]
|
|
