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Development, Vol 126, Issue 5 927-934, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
S Roth, P Jordan and R Karess
Centre de Genetique Moleculaire, Avenue de la Terrasse, France.
The position of the nucleus along the anterior rim of stage 8 Drosophila oocytes presages the dorsal side of the egg and the developing embryo. In this paper, we address the question of whether the oocyte has a previously determined dorsal side to which the nucleus is drawn, or whether nuclear position randomly determines the dorsal side. To do so, we have taken advantage of a genetic system in which Drosophila oocytes occasionally become binuclear. We find that (i) the two nuclei migrate independently to their respective positions on the anterior rim, sometimes selecting the same site, sometimes not, (ii) the two nuclei are equivalent in their ability to induce a dorsal-ventral pattern in the overlying follicular epithelium, and (iii) at any position around the anterior circumference of the egg chamber the follicle cell sheet is equally responsive to the Gurken signal associated with the oocyte nuclei. These results argue that the dorsal-ventral axis is determined arbitrarily by the randomly selected position of the nucleus on the anterior rim of the oocyte. Some of the binuclear eggs support embryonic development. However, despite the duplication of dorsal chorion structures, the majority of such embryos show normal dorsal-ventral patterning. Thus, processes exist in the ventral follicular epithelium or in the perivitelline space that compensate for the expansion of dorsal follicle cell fates and consequently allow the formation of a normal embryonic axis.
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 F. Peri, M. Technau, and S. Roth Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila Development, March 8, 2003; 129(12): 2965 - 2975. [Abstract] [Full Text] [PDF]
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K. E. James, J. B. Dorman, and C. A. Berg Mosaic analyses reveal the function of Drosophila Ras in embryonic dorsoventral patterning and dorsal follicle cell morphogenesis Development, January 5, 2002; 129(9): 2209 - 2222. [Abstract] [Full Text] [PDF]
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G Chen, K Handel, and S Roth The maternal NF-kappaB/dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle Development, January 12, 2000; 127(23): 5145 - 5156. [Abstract] [PDF]
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H Araujo and E Bier sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo Development, January 8, 2000; 127(16): 3631 - 3644. [Abstract] [PDF]
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F Peri and S Roth Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg Development, January 2, 2000; 127(4): 841 - 850. [Abstract] [PDF]
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P. Sadler and D. Shakes Anucleate Caenorhabditis elegans sperm can crawl, fertilize oocytes and direct anterior-posterior polarization of the 1-cell embryo Development, January 1, 2000; 127(2): 355 - 366. [Abstract] [PDF]
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