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Development, Vol 126, Issue 5 975-985, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
R Nagaraj, AT Pickup, R Howes, K Moses, M Freeman and U Banerjee
Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA.
Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We propose that a short-range signal originating from the core of the D/V boundary cells is responsible for activating EGFR in a zone of organizing cells on the edges of the D/V boundary. Using loss-of-function mutations and ectopic expression studies, we show that EGFR signaling is essential for vestigial transcription in these cells and for making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.
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