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Development, Vol 126, Issue 6 1235-1246, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
J Malicki and W Driever
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Bldg. 149, Charlestown, MA 02129, USA. jarema_malicki@meei.harvard.edu
Mutations of the oko meduzy (ome) locus cause drastic neuronal patterning defect in the zebrafish retina. The precise, stratified appearance of the wild-type retina is absent in the mutants. Despite the lack of lamination, at least seven retinal cell types differentiate in oko meduzy. The ome phenotype is already expressed in the retinal neuroepithelium affecting morphology of the neuroepithelial cells. Our experiments indicate that previously unknown cell-cell interactions are involved in development of the retinal neuroepithelial sheet. In genetically mosaic animals, cell-cell interactions are sufficient to rescue the phenotype of oko meduzy retinal neuroepithelial cells. These cell-cell interactions may play a critical role in the patterning events that lead to differentiation of distinct neuronal laminae in the vertebrate retina.
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