|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 126, Issue 8 1753-1768, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
MJ Solloway and EJ Robertson
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. ejrobert@husc.harvard.edu
Members of the BMP family of signaling molecules display a high conservation of structure and function, and multiple BMPs are often coexpressed in a variety of tissues during development. Moreover, distinct BMP ligands are capable of activating common pathways. Here we describe the coexpression of two members of the 60A subfamily of BMPs, Bmp5 and Bmp7, at a number of different sites in the embryo from gastrulation onwards. Previous studies demonstrate that loss of either Bmp5 or Bmp7 has negligible effects on development, suggesting these molecules functionally compensate for each other at early stages of embryonic development. Here we show this is indeed the case. Thus we find that Bmp5;Bmp7 double mutants die at 10.5 dpc and display striking defects primarily affecting the tissues where these factors are coexpressed. The present analysis also uncovers novel roles for BMP signaling during the development of the allantois, heart, branchial arches, somites and forebrain. Bmp5 and Bmp7 do not appear to be involved in establishing pattern in these tissues, but are instead necessary for the proliferation and maintenance of specific cell populations. These findings are discussed with respect to potential mechanisms underlying cooperative signaling by multiple members of the TGF-beta superfamily.
This article has been cited by other articles:
|
|
 |
|
  N. Mine, R. M. Anderson, and J. Klingensmith BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment Development, July 15, 2008; 135(14): 2425 - 2434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Elso, X. Lu, S. Morrison, A. Tarver, H. Thompson, H. Thurkow, N. A. Yamada, and L. Stubbs Germline Translocations in Mice: Unique Tools for Analyzing Gene Function and Long-Distance Regulatory Mechanisms J Natl Cancer Inst Monographs, July 1, 2008; 2008(39): 91 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen An Illustrated Review of Early Pancreas Development in the Mouse Endocr. Rev., October 1, 2007; 28(6): 685 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Muller, H. Rohrer, and A. Vogel-Hopker Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo Development, October 1, 2007; 134(19): 3483 - 3493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Di-Gregorio, M. Sancho, D. W. Stuckey, L. A. Crompton, J. Godwin, Y. Mishina, and T. A. Rodriguez BMP signalling inhibits premature neural differentiation in the mouse embryo Development, September 15, 2007; 134(18): 3359 - 3369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. van Wijk, A. F.M. Moorman, and M. J.B. van den Hoff Role of bone morphogenetic proteins in cardiac differentiation Cardiovasc Res, May 1, 2007; 74(2): 244 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Choi, R. W. Stottmann, Y.-P. Yang, E. N. Meyers, and J. Klingensmith The Bone Morphogenetic Protein Antagonist Noggin Regulates Mammalian Cardiac Morphogenesis Circ. Res., February 2, 2007; 100(2): 220 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Bosman, K. A. Lawson, J. Debruyn, L. Beek, A. Francis, L. Schoonjans, D. Huylebroeck, and A. Zwijsen Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels Development, September 1, 2006; 133(17): 3399 - 3409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L Jones, C. Stoikos, J. K Findlay, and L. A Salamonsen TGF-{beta} superfamily expression and actions in the endometrium and placenta. Reproduction, August 1, 2006; 132(2): 217 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Cheng, C.-m. Hsu, D. S. Currle, J. S. Hu, A. J. Barkovich, and E. S. Monuki Central roles of the roof plate in telencephalic development and holoprosencephaly. J. Neurosci., July 19, 2006; 26(29): 7640 - 7649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ma, M.-F. Lu, R. J. Schwartz, and J. F. Martin Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning Development, December 15, 2005; 132(24): 5601 - 5611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pierre, C. Pisselet, J. Dupont, M. Bontoux, and P. Monget Bone Morphogenetic Protein 5 Expression in the Rat Ovary: Biological Effects on Granulosa Cell Proliferation and Steroidogenesis Biol Reprod, December 1, 2005; 73(6): 1102 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, N. Xu, X. Feng, N. Hou, J. Zhang, X. Cheng, Y. Chen, Y. Zhang, and X. Yang Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure Circ. Res., October 14, 2005; 97(8): 821 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.D. Bartlett, S.E. Dwyer, E. Beniash, Z. Skobe, and T.L. Payne-Ferreira Fluorosis: A New Model and New Insights J. Dent. Res., September 1, 2005; 84(9): 832 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Watson and J. C. Cross Development of Structures and Transport Functions in the Mouse Placenta Physiology, June 1, 2005; 20(3): 180 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hester, J. C. Thompson, J. Mills, Y. Liu, H. M. El-Hodiri, and M. Weinstein Smad1 and Smad8 Function Similarly in Mammalian Central Nervous System Development Mol. Cell. Biol., June 1, 2005; 25(11): 4683 - 4692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Cai, W. Zhou, L. Yang, L. Bu, Y. Qyang, X. Zhang, X. Li, M. G. Rosenfeld, J. Chen, and S. Evans T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis Development, May 15, 2005; 132(10): 2475 - 2487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zakin, B. Reversade, H. Kuroda, K. M. Lyons, and E. M. De Robertis Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm Development, May 15, 2005; 132(10): 2489 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Parekh, A. McEwen, V. Barbour, Y. Takahashi, J. E. Rehg, S. M. Jane, and J. M. Cunningham Defective Extraembryonic Angiogenesis in Mice Lacking LBP-1a, a Member of the grainyhead Family of Transcription Factors Mol. Cell. Biol., August 15, 2004; 24(16): 7113 - 7129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kaartinen, M. Dudas, A. Nagy, S. Sridurongrit, M. M. Lu, and J. A. Epstein Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells Development, July 15, 2004; 131(14): 3481 - 3490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, S. Shi, L. Acosta, W. Li, J. Lu, S. Bao, Z. Chen, Z. Yang, M. D. Schneider, K. R. Chien, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis Development, May 1, 2004; 131(9): 2219 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Stottmann, M. Choi, Y. Mishina, E. N. Meyers, and J. Klingensmith BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium Development, May 1, 2004; 131(9): 2205 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. M. MOORMAN and V. M. CHRISTOFFELS Cardiac Chamber Formation: Development, Genes, and Evolution Physiol Rev, October 1, 2003; 83(4): 1223 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bachiller, J. Klingensmith, N. Shneyder, U. Tran, R. Anderson, J. Rossant, and E. M. De Robertis The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome Development, August 1, 2003; 130(15): 3567 - 3578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Naiche and V. E. Papaioannou Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois Development, June 15, 2003; 130(12): 2681 - 2693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. CROSS, D. G. SIMMONS, and E. D. WATSON Chorioallantoic Morphogenesis and Formation of the Placental Villous Tree Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 84 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Solloway and R. P. Harvey Molecular pathways in myocardial development: a stem cell perspective Cardiovasc Res, May 1, 2003; 58(2): 264 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Muller and H. Rohrer Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage Development, March 14, 2003; 129(24): 5707 - 5717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vogel-Hopker and H. Rohrer The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs) Development, March 4, 2003; 129(4): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chang, C. W. Brown, and M. M. Matzuk Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily Endocr. Rev., December 1, 2002; 23(6): 787 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. A. Vitt, S. Mazerbourg, C. Klein, and A. J.W. Hsueh Bone Morphogenetic Protein Receptor Type II Is a Receptor for Growth Differentiation Factor-9 Biol Reprod, August 1, 2002; 67(2): 473 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gaussin, T. Van de Putte, Y. Mishina, M. C. Hanks, A. Zwijsen, D. Huylebroeck, R. R. Behringer, and M. D. Schneider Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3 PNAS, February 14, 2002; (2002) 42390499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Edelman and J. A. Gally Degeneracy and complexity in biological systems PNAS, October 31, 2001; (2001) 231499798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Tremblay, N. R. Dunn, and E. J. Robertson Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation Development, September 15, 2001; 128(18): 3609 - 3621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest Development, August 1, 2001; 128(15): 3017 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Rossi, N. R. Dunn, B. L.M. Hogan, and K. S. Zaret Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm Genes & Dev., August 1, 2001; 15(15): 1998 - 2009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Trousse, P. Esteve, and P. Bovolenta BMP4 Mediates Apoptotic Cell Death in the Developing Chick Eye J. Neurosci., February 15, 2001; 21(4): 1292 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Yun, S Potter, and J. Rubenstein Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon Development, January 1, 2001; 128(2): 193 - 205. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Ying, X.-M. Liu, A. Marble, K. A. Lawson, and G.-Q. Zhao Requirement of Bmp8b for the Generation of Primordial Germ Cells in the Mouse Mol. Endocrinol., July 1, 2000; 14(7): 1053 - 1063. [Abstract] [Full Text]
|
|
|
|
|
|
D. B. Constam and E. J. Robertson SPC4/PACE4 regulates a TGFbeta signaling network during axis formation Genes & Dev., May 1, 2000; 14(9): 1146 - 1155. [Abstract] [Full Text]
|
|
|
|
|
|
M Mallo, H Schrewe, J. Martin, E. Olson, and S Ohnemus Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium Development, January 10, 2000; 127(19): 4127 - 4136. [Abstract] [PDF]
|
|
|
|
|
|
K. Tremblay, P. Hoodless, E. Bikoff, and E. Robertson Formation of the definitive endoderm in mouse is a Smad2-dependent process Development, January 7, 2000; 127(14): 3079 - 3090. [Abstract] [PDF]
|
|
|
|
|
|
B Schmid, M Furthauer, S. Connors, J Trout, B Thisse, C Thisse, and M. Mullins Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation Development, January 3, 2000; 127(5): 957 - 967. [Abstract] [PDF]
|
|
|
|
|
|
B Kanzler, R. Foreman, P. Labosky, and M Mallo BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest Development, January 3, 2000; 127(5): 1095 - 1104. [Abstract] [PDF]
|
|
|
|
|
|
K. Barth, Y Kishimoto, K. Rohr, C Seydler, S Schulte-Merker, and S. Wilson Bmp activity establishes a gradient of positional information throughout the entire neural plate Development, January 11, 1999; 126(22): 4977 - 4987. [Abstract] [PDF]
|
|
|
|
|
|
V. Gaussin, T. Van de Putte, Y. Mishina, M. C. Hanks, A. Zwijsen, D. Huylebroeck, R. R. Behringer, and M. D. Schneider Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3 PNAS, March 5, 2002; 99(5): 2878 - 2883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Edelman and J. A. Gally Degeneracy and complexity in biological systems PNAS, November 20, 2001; 98(24): 13763 - 13768. [Abstract] [Full Text] [PDF]
|
|
