spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, R. B.
Right arrow Articles by Key, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, R. B.
Right arrow Articles by Key, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Development, Vol 126, Issue 9 1859-1868, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Novel guidance cues during neuronal pathfinding in the early scaffold of axon tracts in the rostral brain

RB Anderson and B Key
Neurodevelopment Laboratory, Department of Anatomy and Cell Biology, University of Melbourne, Parkville 3052, Australia.

A scaffold of axons consisting of a pair of longitudinal tracts and several commissures is established during early development of the vertebrate brain. We report here that NOC-2, a cell surface carbohydrate, is selectively expressed by a subpopulation of growing axons in this scaffold in Xenopus. NOC-2 is present on two glycoproteins, one of which is a novel glycoform of the neural cell adhesion molecule N-CAM. When the function of NOC-2 was perturbed using either soluble carbohydrates or anti-NOC-2 antibodies, axons expressing NOC-2 exhibited aberrant growth at specific points in their pathway. NOC-2 is the first-identified axon guidance molecule essential for development of the axon scaffold in the embryonic vertebrate brain.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
G. L. Andrews and G. S. Mastick
R-Cadherin Is a Pax6-Regulated, Growth-Promoting Cue for Pioneer Axons
J. Neurosci., October 29, 2003; 23(30): 9873 - 9880.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Ichijo and I. Kawabata
Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway
J. Neurosci., December 1, 2001; 21(23): 9304 - 9314.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1999