|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 10 2011-2019, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
V Vendrell, E Carnicero, F Giraldez, MT Alonso and T Schimmang
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Departamento de Bioquimica, Biologia Molecular y Fisiologia, Facultad de Medicina, E-47005 Valladolid, Spain.
Loss-of-function experiments in avians and mammals have provided conflicting results on the capacity of fibroblast growth factor 3 (FGF3) to act as a secreted growth factor responsible for induction and morphogenesis of the vertebrate inner ear. Using a novel technique for gene transfer into chicken embryos, we have readdressed the role of FGF3 during inner ear development in avians. We find that ectopic expression of FGF3 results in the formation of ectopic placodes which express otic marker genes. The ectopically induced placodes form vesicles which show the characteristic gene expression pattern of a developing inner ear. Ectopic expression of FGF3 also influences the formation of the normal orthotopic inner ear, whereas another member of the FGF family, FGF2, shows no effects on inner ear induction. These results demonstrate that a single gene can induce inner ear fate and reveal an unexpectedly widespread competence of the surface ectoderm to form sensory placodes in higher vertebrates.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Bhattacharyya and M. Bronner-Fraser Competence, specification and commitment to an olfactory placode fate Development, December 15, 2008; 135(24): 4165 - 4177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Freter, Y. Muta, S.-S. Mak, S. Rinkwitz, and R. K. Ladher Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential Development, October 15, 2008; 135(20): 3415 - 3424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode Development, July 1, 2008; 135(13): 2251 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Barembaum and M. Bronner-Fraser Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm Development, November 1, 2007; 134(21): 3805 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Daudet, L. Ariza-McNaughton, and J. Lewis Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear Development, June 15, 2007; 134(12): 2369 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Martin and A. K. Groves Competence of cranial ectoderm to respond to Fgf signaling suggests a two-step model of otic placode induction Development, March 1, 2006; 133(5): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Litsiou, S. Hanson, and A. Streit A balance of FGF, BMP and WNT signalling positions the future placode territory in the head Development, September 15, 2005; 132(18): 4051 - 4062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lin, R. Cantos, M. Patente, and D. K. Wu Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling Development, May 15, 2005; 132(10): 2309 - 2318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Ladher, T. J. Wright, A. M. Moon, S. L. Mansour, and G. C. Schoenwolf FGF8 initiates inner ear induction in chick and mouse Genes & Dev., March 1, 2005; 19(5): 603 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chang, J. V. Brigande, D. M. Fekete, and D. K. Wu The development of semicircular canals in the inner ear: role of FGFs in sensory cristae Development, September 1, 2004; 131(17): 4201 - 4211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Saint-Germain, Y.-H. Lee, Y. Zhang, T. D. Sargent, and J.-P. Saint-Jeannet Specification of the otic placode depends on Sox9 function in Xenopus Development, April 15, 2004; 131(8): 1755 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Alvarez, M. T. Alonso, V. Vendrell, L. C. Zelarayan, P. Chamero, T. Theil, M. R. Bosl, S. Kato, M. Maconochie, D. Riethmacher, et al. Requirements for FGF3 and FGF10 during inner ear formation Development, December 22, 2003; 130(25): 6329 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Wright and S. L. Mansour Fgf3 and Fgf10 are required for mouse otic placode induction Development, August 1, 2003; 130(15): 3379 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liu, H. Chu, L. Maves, Y.-L. Yan, P. A. Morcos, J. H. Postlethwait, and M. Westerfield Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification Development, May 15, 2003; 130(10): 2213 - 2224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Solomon, T. Kudoh, I. B. Dawid, and A. Fritz Zebrafish foxi1 mediates otic placode formation and jaw development Development, March 1, 2003; 130(5): 929 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Ladher, K. U. Anakwe, A. L. Gurney, G. C. Schoenwolf, and P. H. Francis-West Identification of Synergistic Signals Initiating Inner Ear Development Science, December 8, 2000; 290(5498): 1965 - 1967. [Abstract] [Full Text]
|
|
|
|
|
|
M. Liu, F. A. Pereira, S. D. Price, M.-j. Chu, C. Shope, D. Himes, R. A. Eatock, W. E. Brownell, A. Lysakowski, and M.-J. Tsai Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems Genes & Dev., November 15, 2000; 14(22): 2839 - 2854. [Abstract] [Full Text]
|
|
|
|
|
|
A. Groves and M Bronner-Fraser Competence, specification and commitment in otic placode induction Development, January 8, 2000; 127(16): 3489 - 3499. [Abstract] [PDF]
|
|
