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Development, Vol 127, Issue 10 2227-2238, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
M Tada and JC Smith
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
Gastrulation in the amphibian embryo is driven by cells of the mesoderm. One of the genes that confers mesodermal identity in Xenopus is Brachyury (Xbra), which is required for normal gastrulation movements and ultimately for posterior mesoderm and notochord differentiation in the development of all vertebrates. Xbra is a transcription activator, and interference with transcription activation leads to an inhibition of morphogenetic movements during gastrulation. To understand this process, we have screened for downstream target genes of Brachyury (Tada, M., Casey, E., Fairclough, L. and Smith, J. C. (1998) Development 125, 3997-4006). This approach has now allowed us to isolate Xwnt11, whose expression pattern is almost identical to that of Xbra at gastrula and early neurula stages. Activation of Xwnt11 is induced in an immediate-early fashion by Xbra and its expression in vivo is abolished by a dominant-interfering form of Xbra, Xbra-En(R). Overexpression of a dominant-negative form of Xwnt11, like overexpression of Xbra-En(R), inhibits convergent extension movements. This inhibition can be rescued by Dsh, a component of the Wnt signalling pathway and also by a truncated form of Dsh which cannot signal through the canonical Wnt pathway involving GSK-3 and (beta)-catenin. Together, our results suggest that the regulation of morphogenetic movements by Xwnt11 occurs through a pathway similar to that involved in planar polarity signalling in Drosophila.
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 M. Heikkila, H. Peltoketo, J. Leppaluoto, M. Ilves, O. Vuolteenaho, and S. Vainio Wnt-4 Deficiency Alters Mouse Adrenal Cortex Function, Reducing Aldosterone Production Endocrinology, November 1, 2002; 143(11): 4358 - 4365. [Abstract] [Full Text] [PDF]
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H. Petropoulos and I. S. Skerjanc beta -Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells J. Biol. Chem., May 3, 2002; 277(18): 15393 - 15399. [Abstract] [Full Text] [PDF]
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 H. Lee and P. N. Adler The Function of the frizzled Pathway in the Drosophila Wing Is Dependent on inturned and fuzzy Genetics, April 1, 2002; 160(4): 1535 - 1547. [Abstract] [Full Text] [PDF]
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O'N. Wiggan and P. A. Hamel Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade J. Cell Sci., January 2, 2002; 115(3): 531 - 541. [Abstract] [Full Text] [PDF]
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F. L. Conlon, L. Fairclough, B. M. J. Price, E. S. Casey, and J. C. Smith Determinants of T box protein specificity Development, October 1, 2001; 128(19): 3749 - 3758. [Abstract] [Full Text] [PDF]
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G. Begemann, T. F. Schilling, G.-J. Rauch, R. Geisler, and P. W. Ingham The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain Development, August 15, 2001; 128(16): 3081 - 3094. [Abstract] [Full Text] [PDF]
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I. Skromne and C. D. Stern Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo Development, August 1, 2001; 128(15): 2915 - 2927. [Abstract] [Full Text] [PDF]
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J. D. Axelrod Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling Genes & Dev., May 15, 2001; 15(10): 1182 - 1187. [Abstract] [Full Text]
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S. L. Nutt, K. S. Dingwell, C. E. Holt, and E. Amaya Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning Genes & Dev., May 1, 2001; 15(9): 1152 - 1166. [Abstract] [Full Text]
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D. Yan, J. B. Wallingford, T.-Q. Sun, A. M. Nelson, C. Sakanaka, C. Reinhard, R. M. Harland, W. J. Fantl, and L. T. Williams Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd PNAS, March 27, 2001; 98(7): 3802 - 3807. [Abstract] [Full Text] [PDF]
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J. T. Rasmussen, M. A. Deardorff, C. Tan, M. S. Rao, P. S. Klein, and M. L. Vetter Regulation of eye development by frizzled signaling in Xenopus PNAS, March 27, 2001; 98(7): 3861 - 3866. [Abstract] [Full Text] [PDF]
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S.-i. Hino, S. Kishida, T. Michiue, A. Fukui, I. Sakamoto, S. Takada, M. Asashima, and A. Kikuchi Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein Mol. Cell. Biol., January 1, 2001; 21(1): 330 - 342. [Abstract] [Full Text]
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O. Krylova, M. J. Messenger, and P. C. Salinas Dishevelled-1 Regulates Microtubule Stability: A New Function Mediated by Glycogen Synthase Kinase-3{beta} J. Cell Biol., October 3, 2000; 151(1): 83 - 94. [Abstract] [Full Text] [PDF]
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A Djiane, J Riou, M Umbhauer, J Boucaut, and D Shi Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis Development, January 7, 2000; 127(14): 3091 - 3100. [Abstract] [PDF]
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A. Scherer and J. M. Graff Calmodulin Differentially Modulates Smad1 and Smad2 Signaling J. Biol. Chem., December 22, 2000; 275(52): 41430 - 41438. [Abstract] [Full Text] [PDF]
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