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Development, Vol 127, Issue 11 2317-2322, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
PL Herrera
Department of Morphology, University of Geneva Medical School, rue Michel-Servet, Switzerland. pedro.herrera@medecine.unige.ch
To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon alpha and insulin beta cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the beta-cell progenitors, but not alpha-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult beta-cells, is also expressed by alpha-cell progenitors. Thus the islet alpha- and beta-cell lineages appear to arise independently during ontogeny, probably from a common precursor.
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M Sander, L Sussel, J Conners, D Scheel, J Kalamaras, F Dela Cruz, V Schwitzgebel, A Hayes-Jordan, and M German Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas Development, January 12, 2000; 127(24): 5533 - 5540. [Abstract] [PDF]
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