|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 11 2323-2332, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
E Cau, G Gradwohl, S Casarosa, R Kageyama and F Guillemot
IGBMC, CNRS/INSERM/Universite Louis Pasteur, BP 163, CU de Strasbourg, France.
We have characterised the functions of the bHLH transcriptional repressors HES1 and HES5 in neurogenesis, using the development of the olfactory placodes in mouse embryos as a model. Hes1 and Hes5 are expressed with distinct patterns in the olfactory placodes and are subject to different regulatory mechanisms. Hes1 is expressed in a broad placodal domain, which is maintained in absence of the neural determination gene Mash1. In contrast, expression of Hes5 is restricted to clusters of neural progenitor cells and requires Mash1 function. Mutations in Hes1 and Hes5 also have distinct consequences on olfactory placode neurogenesis. Loss of Hes1 function leads both to expression of Mash1 outside of the normal domain of neurogenesis and to increased density of MASH1-positive progenitors within this domain, and results in an excess of neurons after a delay. A mutation in Hes5 does not produce any apparent defect. However, olfactory placodes that are double mutant for Hes1 and Hes5 upregulate Ngn1, a neural bHLH gene activated downstream of Mash1, and show a strong and rapid increase in neuronal density. Together, our results suggest that Hes1 regulates Mash1 transcription in the olfactory placode in two different contexts, initially as a prepattern gene defining the placodal domain undergoing neurogenesis and, subsequently, as a neurogenic gene controlling the density of neural progenitors in this domain. Hes5 synergizes with Hes1 and regulates neurogenesis at the level of Ngn1 expression. Therefore, the olfactory sensory neuron lineage is regulated at several steps by negative signals acting through different Hes genes and targeting the expression of different proneural gene homologs.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. N. Riesenberg, Z. Liu, R. Kopan, and N. L. Brown Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina J. Neurosci., October 14, 2009; 29(41): 12865 - 12877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Havrda, B. T. Harris, A. Mantani, N. M. Ward, B. R. Paolella, V. C. Cuzon, H. H. Yeh, and M. A. Israel Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis J. Neurosci., December 24, 2008; 28(52): 14074 - 14087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Varnum-Finney, M. H. Dallas, K. Kato, and I. D. Bernstein Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus Blood, March 1, 2008; 111(5): 2615 - 2620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. D Allen Temporal and epigenetic regulation of neurodevelopmental plasticity Phil Trans R Soc B, January 12, 2008; 363(1489): 23 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fischer and M. Gessler Delta Notch and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors Nucleic Acids Res., July 14, 2007; 35(14): 4583 - 4596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kita, I. Imayoshi, M. Hojo, M. Kitagawa, H. Kokubu, R. Ohsawa, T. Ohtsuka, R. Kageyama, and N. Hashimoto Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development Mol. Endocrinol., June 1, 2007; 21(6): 1458 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Feldmesser, D. Bercovich, N. Avidan, S. Halbertal, L. Haim, R. Gross-Isseroff, S. Goshen, and D. Lancet Mutations in Olfactory Signal Transduction Genes Are Not a Major Cause of Human Congenital General Anosmia Chem Senses, January 1, 2007; 32(1): 21 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Matter-Sadzinski, M. Puzianowska-Kuznicka, J. Hernandez, M. Ballivet, and J.-M. Matter A bHLH transcriptional network regulating the specification of retinal ganglion cells Development, September 1, 2005; 132(17): 3907 - 3921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-K. Bae, T. Shimizu, and M. Hibi Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm Development, March 15, 2005; 132(6): 1375 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Seta, T. Toyono, S. Kataoka, and K. Toyoshima Regulation of Taste Bud Cell Differentiation by Notch Signaling Pathway Chem Senses, January 1, 2005; 30(suppl_1): i48 - i49. [Full Text] [PDF]
|
|
|
|
|
|
J. Hatakeyama, Y. Bessho, K. Katoh, S. Ookawara, M. Fujioka, F. Guillemot, and R. Kageyama Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation Development, November 15, 2004; 131(22): 5539 - 5550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Oldekamp, N. Kraemer, G. Alvarez-Bolado, and T. Skutella bHLH Gene Expression in the Emx2-deficient Dentate Gyrus Reveals Defective Granule Cells and Absence of Migrating Precursors Cereb Cortex, September 1, 2004; 14(9): 1045 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. T. Cunliffe Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling Development, June 15, 2004; 131(12): 2983 - 2995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hirota and P. Mombaerts The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons PNAS, June 8, 2004; 101(23): 8751 - 8755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Geling, C. Plessy, S. Rastegar, U. Strahle, and L. Bally-Cuif Her5 acts as a prepattern factor that blocks neurogenin1 and coe2 expression upstream of Notch to inhibit neurogenesis at the midbrain-hindbrain boundary Development, May 1, 2004; 131(9): 1993 - 2006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Wang, J. W. Lewcock, P. Feinstein, P. Mombaerts, and R. R. Reed Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection Development, March 15, 2004; 131(6): 1377 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gazit, V. Krizhanovsky, and N. Ben-Arie Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway Development, February 15, 2004; 131(4): 903 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Suzuki, E. Tsuruga, T. Yajima, and M. Takeda Expression of bHLH Transcription Factors NSCL1 and NSCL2 in the Mouse Olfactory System Chem Senses, September 1, 2003; 28(7): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cau and S. W. Wilson Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis Development, June 1, 2003; 130(11): 2455 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Geling, M. Itoh, A. Tallafuss, P. Chapouton, B. Tannhauser, J. Y. Kuwada, A. B. Chitnis, and L. Bally-Cuif bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary Development, April 15, 2003; 130(8): 1591 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dubreuil, M.-R. Hirsch, C. Jouve, J.-F. Brunet, and C. Goridis The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis Development, March 13, 2003; 129(22): 5241 - 5253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cau, S. Casarosa, and F. Guillemot Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage Development, March 6, 2003; 129(8): 1871 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lutolf, F. Radtke, M. Aguet, U. Suter, and V. Taylor Notch1 is required for neuronal and glial differentiation in the cerebellum Development, March 3, 2003; 129(2): 373 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Suzuki, I. Mizoguchi, H. Nishiyama, M. Takeda, and N. Obara Expression of Hes6 and NeuroD in the Olfactory Epithelium, Vomeronasal Organ and Non-sensory Patches Chem Senses, March 1, 2003; 28(3): 197 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chojnacki, T. Shimazaki, C. Gregg, G. Weinmaster, and S. Weiss Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells J. Neurosci., March 1, 2003; 23(5): 1730 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Murray, D. Navi, J. Fesenko, A. D. Lander, and A. L. Calof Widespread Defects in the Primary Olfactory Pathway Caused by Loss of Mash1 Function J. Neurosci., March 1, 2003; 23(5): 1769 - 1780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kunisato, S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo Blood, March 1, 2003; 101(5): 1777 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bernaudin, Y. Tang, M. Reilly, E. Petit, and F. R. Sharp Brain Genomic Response following Hypoxia and Re-oxygenation in the Neonatal Rat. IDENTIFICATION OF GENES THAT MIGHT CONTRIBUTE TO HYPOXIA-INDUCED ISCHEMIC TOLERANCE J. Biol. Chem., October 11, 2002; 277(42): 39728 - 39738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Sriuranpong, M. W. Borges, C. L. Strock, E. K. Nakakura, D. N. Watkins, C. M. Blaumueller, B. D. Nelkin, and D. W. Ball Notch Signaling Induces Rapid Degradation of Achaete-Scute Homolog 1 Mol. Cell. Biol., May 1, 2002; 22(9): 3129 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kabos, A. Kabosova, and T. Neuman Blocking HES1 Expression Initiates GABAergic Differentiation and Induces the Expression of p21CIP1/WAF1 in Human Neural Stem Cells J. Biol. Chem., March 8, 2002; 277(11): 8763 - 8766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yun, S. Fischman, J. Johnson, M. H. de Angelis, G. Weinmaster, and J. L. R. Rubenstein Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon Development, January 11, 2002; 129(21): 5029 - 5040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sedaghat, W. F. Miranda, and M. J. Sonnenfeld The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea Development, January 6, 2002; 129(11): 2591 - 2606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-E. Legrier, A. Ducray, A. Propper, M. Chao, and A. Kastner Cell Cycle Regulation during Mouse Olfactory Neurogenesis Cell Growth Differ., December 1, 2001; 12(12): 591 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zine, A. Aubert, J. Qiu, S. Therianos, F. Guillemot, R. Kageyama, and F. de Ribaupierre Hes1 and Hes5 Activities Are Required for the Normal Development of the Hair Cells in the Mammalian Inner Ear J. Neurosci., July 1, 2001; 21(13): 4712 - 4720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Satow, S.-K. Bae, T. Inoue, C. Inoue, G. Miyoshi, K. Tomita, Y. Bessho, N. Hashimoto, and R. Kageyama The Basic Helix-Loop-Helix Gene hesr2 Promotes Gliogenesis in Mouse Retina J. Neurosci., February 15, 2001; 21(4): 1265 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Hassan and H. J. Bellen Doing the MATH: is the mouse a good model for fly development? Genes & Dev., August 1, 2000; 14(15): 1852 - 1865. [Full Text]
|
|
|
|
|
|
V Dubreuil, M Hirsch, A Pattyn, J Brunet, and C Goridis The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity Development, January 12, 2000; 127(23): 5191 - 5201. [Abstract] [PDF]
|
|
|
|
|
|
M Hojo, T Ohtsuka, N Hashimoto, G Gradwohl, F Guillemot, and R Kageyama Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina Development, January 6, 2000; 127(12): 2515 - 2522. [Abstract] [PDF]
|
|
|
|
|
|
T. Ohtsuka, M. Sakamoto, F. Guillemot, and R. Kageyama Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain J. Biol. Chem., August 3, 2001; 276(32): 30467 - 30474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakashima, T. Takizawa, W. Ochiai, M. Yanagisawa, T. Hisatsune, M. Nakafuku, K. Miyazono, T. Kishimoto, R. Kageyama, and T. Taga BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis PNAS, May 8, 2001; 98(10): 5868 - 5873. [Abstract] [Full Text] [PDF]
|
|
