|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Development, Vol 127, Issue 12 2593-2606, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
M Handler, X Yang and J Shen
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Mutations in Presenilin-1 (PS1) are a major cause of familial Alzheimer's disease. Our previous studies showed that PS1 is required for murine neural development. Here we report that lack of PS1 leads to premature differentiation of neural progenitor cells, indicating a role for PS1 in a cell fate decision between postmitotic neurons and neural progenitor cells. Neural proliferation and apoptotic cell death during neurogenesis are unaltered in PS1(-/-) mice, suggesting that the reduction in the neural progenitor cells observed in the PS1(-/-) brain is due to premature differentiation of progenitor cells, rather than to increased apoptotic cell death or decreased cell proliferation. In addition, the premature neuronal differentiation in the PS1(-/-) brain is associated with aberrant neuronal migration and disorganization of the laminar architecture of the developing cerebral hemisphere. In the ventricular zone of PS1(-/-) mice, expression of the Notch1 downstream effector gene Hes5 is reduced and expression of the Notch1 ligand Dll1 is elevated, whereas expression of Notch1 is unchanged. The level of Dll1 transcripts is also increased in the presomitic mesoderm of PS1(-/-) embryos, while the level of Notch1 transcripts is unchanged, in contrast to a previous report (Wong et al., 1997, Nature 387, 288-292). These results provide direct evidence that PS1 controls neuronal differentiation in association with the downregulation of Notch signalling during neurogenesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Iulianella, M. Sharma, G. B. Vanden Heuvel, and P. A. Trainor Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord Development, July 15, 2009; 136(14): 2329 - 2334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Reiner, A. Shmueli, and T. Sapir Neuronal Migration and Neurodegeneration: 2 Sides of the Same Coin Cereb Cortex, July 1, 2009; 19(suppl_1): i42 - i48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Watanabe, M. J. Smith, E. Heilig, V. Beglopoulos, R. J. Kelleher III, and J. Shen Indirect Regulation of Presenilins in CREB-mediated Transcription J. Biol. Chem., May 15, 2009; 284(20): 13705 - 13713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Q. Doe Neural stem cells: balancing self-renewal with differentiation Development, May 1, 2008; 135(9): 1575 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Briscoe and B. G Novitch Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube Phil Trans R Soc B, January 12, 2008; 363(1489): 57 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, A. Zacharek, A. Li, X. Cui, C. Roberts, M. Lu, and M. Chopp Atorvastatin Promotes Presenilin-1 Expression and Notch1 Activity and Increases Neural Progenitor Cell Proliferation After Stroke Stroke, January 1, 2008; 39(1): 220 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ringman, J. O'Neill, D. Geschwind, L. Medina, L. G. Apostolova, Y. Rodriguez, B. Schaffer, A. Varpetian, B. Tseng, F. Ortiz, et al. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations Brain, July 1, 2007; 130(7): 1767 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells Phil Trans R Soc B, September 29, 2006; 361(1473): 1477 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wines-Samuelson and J. Shen Presenilins in the Developing, Adult, and Aging Cerebral Cortex Neuroscientist, October 1, 2005; 11(5): 441 - 451. [Abstract] [PDF]
|
|
|
|
|
|
P. H. Wen, R. De Gasperi, M. A. G. Sosa, A. B. Rocher, V. L. Friedrich Jr, P. R. Hof, and G. A. Elder Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice Development, September 1, 2005; 132(17): 3873 - 3883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Saura, G. Chen, S. Malkani, S.-Y. Choi, R. H. Takahashi, D. Zhang, G. K. Gouras, A. Kirkwood, R. G. M. Morris, and J. Shen Conditional Inactivation of Presenilin 1 Prevents Amyloid Accumulation and Temporarily Rescues Contextual and Spatial Working Memory Impairments in Amyloid Precursor Protein Transgenic Mice J. Neurosci., July 20, 2005; 25(29): 6755 - 6764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Chevallier, S. Soriano, D. E. Kang, E. Masliah, G. Hu, and E. H. Koo Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation Am. J. Pathol., July 1, 2005; 167(1): 151 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Kim, L. A. M. Ingano, B. W. Carey, W. H. Pettingell, and D. M. Kovacs Presenilin/{gamma}-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel {beta}2-Subunit Regulates Cell Adhesion and Migration J. Biol. Chem., June 17, 2005; 280(24): 23251 - 23261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Beglopoulos, X. Sun, C. A Saura, C. A. Lemere, R. D. Kim, and J. Shen Reduced {beta}-Amyloid Production and Increased Inflammatory Responses in Presenilin Conditional Knock-out Mice J. Biol. Chem., November 5, 2004; 279(45): 46907 - 46914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hitoshi, R. M. Seaberg, C. Koscik, T. Alexson, S. Kusunoki, I. Kanazawa, S. Tsuji, and D. van der Kooy Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling Genes & Dev., August 1, 2004; 18(15): 1806 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Louvi, S. S. Sisodia, and E. A. Grove Presenilin 1 in migration and morphogenesis in the central nervous system Development, July 1, 2004; 131(13): 3093 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hashimoto, O. Tsuji, K. Kanekura, S. Aiso, T. Niikura, M. Matsuoka, and I. Nishimoto The Gtx Homeodomain Transcription Factor Exerts Neuroprotection Using Its Homeodomain J. Biol. Chem., April 16, 2004; 279(16): 16767 - 16777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Schulz, W. Annaert, J. Vandekerckhove, P. Zimmermann, B. De Strooper, and G. David Syndecan 3 Intramembrane Proteolysis Is Presenilin/{gamma}-Secretase-dependent and Modulates Cytosolic Signaling J. Biol. Chem., December 5, 2003; 278(49): 48651 - 48657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wang, F. A. Pereira, D. Beasley, and H. Zheng Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development, October 15, 2003; 130(20): 5019 - 5029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. KRICHEVSKY, K. S. KING, C. P. DONAHUE, K. KHRAPKO, and K. S. KOSIK A microRNA array reveals extensive regulation of microRNAs during brain development RNA, October 1, 2003; 9(10): 1274 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Imitola, E. Y. Snyder, and S. J. Khoury Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis Physiol Genomics, August 15, 2003; 14(3): 171 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-T. Lai, E. Chen, M.-C. Crouthamel, J. DiMuzio-Mower, M. Xu, Q. Huang, E. Price, R. B. Register, X.-P. Shi, D. B. Donoviel, et al. Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping {gamma}-Secretase Activities J. Biol. Chem., June 13, 2003; 278(25): 22475 - 22481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chojnacki, T. Shimazaki, C. Gregg, G. Weinmaster, and S. Weiss Glycoprotein 130 Signaling Regulates Notch1 Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells J. Neurosci., March 1, 2003; 23(5): 1730 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Xia, P. Wang, X. Sun, S. Soriano, W.-K. Shum, H. Yamaguchi, M. E. Trumbauer, A. Takashima, E. H. Koo, and H. Zheng The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta -amyloid peptides through beta -catenin-independent mechanisms PNAS, June 25, 2002; 99(13): 8760 - 8765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dewachter, D. Reverse, N. Caluwaerts, L. Ris, C. Kuiperi, C. Van den Haute, K. Spittaels, L. Umans, L. Serneels, E. Thiry, et al. Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice J. Neurosci., May 1, 2002; 22(9): 3445 - 3453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hitoshi, T. Alexson, V. Tropepe, D. Donoviel, A. J. Elia, J. S. Nye, R. A. Conlon, T. W. Mak, A. Bernstein, and D. van der Kooy Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells Genes & Dev., April 1, 2002; 16(7): 846 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Berechid, M. Kitzmann, D. R. Foltz, A. H. Roach, D. Seiffert, L. A. Thompson, R. E. Olson, A. Bernstein, D. B. Donoviel, and J. S. Nye Identification and Characterization of Presenilin-independent Notch Signaling J. Biol. Chem., March 1, 2002; 277(10): 8154 - 8165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Faux, A. M. Turnley, R. Epa, R. Cappai, and P. F. Bartlett Interactions between Fibroblast Growth Factors and Notch Regulate Neuronal Differentiation J. Neurosci., August 1, 2001; 21(15): 5587 - 5596. [Abstract] [Full Text] [PDF]
|
|
