spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramalho-Santos, M.
Right arrow Articles by McMahon, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramalho-Santos, M.
Right arrow Articles by McMahon, A. P.

Development, Vol 127, Issue 12 2763-2772, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Hedgehog signals regulate multiple aspects of gastrointestinal development

M Ramalho-Santos, DA Melton and AP McMahon
Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Divinity Avenue, Cambridge, Massachusetts 02138, USA.

The gastrointestinal tract develops from the embryonic gut, which is composed of an endodermally derived epithelium surrounded by cells of mesodermal origin. Cell signaling between these two tissue layers appears to play a critical role in coordinating patterning and organogenesis of the gut and its derivatives. We have assessed the function of Sonic hedgehog and Indian hedgehog genes, which encode members of the Hedgehog family of cell signals. Both are expressed in gut endoderm, whereas target genes are expressed in discrete layers in the mesenchyme. It was unclear whether functional redundancy between the two genes would preclude a genetic analysis of the roles of Hedgehog signaling in the mouse gut. We show here that the mouse gut has both common and separate requirements for Sonic hedgehog and Indian hedgehog. Both Sonic hedgehog and Indian hedgehog mutant mice show reduced smooth muscle, gut malrotation and annular pancreas. Sonic hedgehog mutants display intestinal transformation of the stomach, duodenal stenosis (obstruction), abnormal innervation of the gut and imperforate anus. Indian hedgehog mutants show reduced epithelial stem cell proliferation and differentiation, together with features typical of Hirschsprung's disease (aganglionic colon). These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations.


This article has been cited by other articles:


Home page
 J EndocrinolHome page
P. J King, L. Guasti, and E. Laufer
Hedgehog signalling in endocrine development and disease
J. Endocrinol., September 1, 2008; 198(3): 439 - 450.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. J. Geske, X. Zhang, K. K. Patel, D. M. Ornitz, and T. S. Stappenbeck
Fgf9 signaling regulates small intestinal elongation and mesenchymal development
Development, September 1, 2008; 135(17): 2959 - 2968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Zavros, M. A. Orr, C. Xiao, and D. H. Malinowska
Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation
Am J Physiol Gastrointest Liver Physiol, July 1, 2008; 295(1): G99 - G111.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. L. Tobin, M. Di Franco, E. Eichers, H. May-Simera, M. Garcia, J. Yan, R. Quinlan, M. J. Justice, R. C. Hennekam, J. Briscoe, et al.
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome
PNAS, May 6, 2008; 105(18): 6714 - 6719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Zavros
The Adventures of Sonic Hedgehog in Development and Repair. IV. Sonic hedgehog processing, secretion, and function in the stomach
Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1105 - G1108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. A. Parkin and P. W. Ingham
The Adventures of Sonic Hedgehog in Development and Repair. I. Hedgehog signaling in gastrointestinal development and disease
Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G363 - G367.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
K. R. Badri, Y. Zhou, and L. Schuger
Embryological Origin of Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee
The hematopoietic stem cell and its niche: a comparative view
Genes & Dev., December 1, 2007; 21(23): 3044 - 3060.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zavros, M. Waghray, A. Tessier, L. Bai, A. Todisco, D. L. Gumucio, L. C. Samuelson, A. Dlugosz, and J. L. Merchant
Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation
J. Biol. Chem., November 16, 2007; 282(46): 33265 - 33274.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen
An Illustrated Review of Early Pancreas Development in the Mouse
Endocr. Rev., October 1, 2007; 28(6): 685 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. R. van den Brink
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
Physiol Rev, October 1, 2007; 87(4): 1343 - 1375.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Nitsche, S. Ramamoorthy, M. Sareban, N. Pausawasdi, and A. Todisco
Functional role of bone morphogenetic protein-4 in isolated canine parietal cells
Am J Physiol Gastrointest Liver Physiol, September 1, 2007; 293(3): G607 - G614.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Que, T. Okubo, J. R. Goldenring, K.-T. Nam, R. Kurotani, E. E. Morrisey, O. Taranova, L. H. Pevny, and B. L. M. Hogan
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
Development, July 1, 2007; 134(13): 2521 - 2531.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Z. Li, T. Yu, M. Morishima, A. Pao, J. LaDuca, J. Conroy, N. Nowak, S.-I. Matsui, I. Shiraishi, and Y. E. Yu
Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities
Hum. Mol. Genet., June 1, 2007; 16(11): 1359 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
X. Li, B. B. Madison, W. Zacharias, A. Kolterud, D. States, and D. L. Gumucio
Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk
Physiol Genomics, May 11, 2007; 29(3): 290 - 301.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
V. S. F. Chan, S.-y. Chau, L. Tian, Y. Chen, S. K. Y. Kwong, J. Quackenbush, M. Dallman, J. Lamb, and P. K. H. Tam
Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes
Int. Immunol., December 1, 2006; 18(12): 1627 - 1636.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Torihashi, M. Kuwahara, T. Ogaeri, P. Zhu, M. Kurahashi, and T. Fujimoto
Gut-Like Structures from Mouse Embryonic Stem Cells as an In Vitro Model for Gut Organogenesis Preserving Developmental Potential After Transplantation
Stem Cells, December 1, 2006; 24(12): 2618 - 2626.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
R. G. Jones, X. Li, P. D. Gray, J. Kuang, F. Clayton, W. S. Samowitz, B. B. Madison, D. L. Gumucio, and S. K. Kuwada
Conditional deletion of {beta}1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality
J. Cell Biol., November 6, 2006; 175(3): 505 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Asayesh, J. Sharpe, R. P. Watson, J. Hecksher-Sorensen, N. D. Hastie, R. E. Hill, and U. Ahlgren
Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
Genes & Dev., August 15, 2006; 20(16): 2208 - 2213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Takano-Maruyama, K. Hase, H. Fukamachi, Y. Kato, H. Koseki, and H. Ohno
Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine
Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G163 - G170.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
C Shaw-Smith
Oesophageal atresia, tracheo-oesophageal fistula, and the VACTERL association: review of genetics and epidemiology
J. Med. Genet., July 1, 2006; 43(7): 545 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Tang, E. A. Swietlicki, S. Jiang, K. K. Buhman, N. O. Davidson, L. C. Burkly, M. S. Levin, and D. C. Rubin
Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection
Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1280 - G1288.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Asai, H. Takenaka, K. F. Kusano, M. Ii, C. Luedemann, C. Curry, E. Eaton, A. Iwakura, Y. Tsutsumi, H. Hamada, et al.
Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell-Mediated Microvascular Remodeling
Circulation, May 23, 2006; 113(20): 2413 - 2424.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. K. Sicklick, Y.-X. Li, A. Jayaraman, R. Kannangai, Y. Qi, P. Vivekanandan, J. W. Ludlow, K. Owzar, W. Chen, M. S. Torbenson, et al.
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
Carcinogenesis, April 1, 2006; 27(4): 748 - 757.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Ormestad, J. Astorga, H. Landgren, T. Wang, B. R. Johansson, N. Miura, and P. Carlsson
Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
Development, March 1, 2006; 133(5): 833 - 843.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Pietsch, J.-M. Delalande, B. Jakaitis, J. D. Stensby, S. Dohle, W. S. Talbot, D. W. Raible, and I. T. Shepherd
lessen encodes a zebrafish trap100 required for enteric nervous system development
Development, February 1, 2006; 133(3): 395 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Ohta, K. Tateishi, F. Kanai, H. Watabe, S. Kondo, B. Guleng, Y. Tanaka, Y. Asaoka, A. Jazag, J. Imamura, et al.
p53-Independent Negative Regulation of p21/Cyclin-Dependent Kinase-Interacting Protein 1 by the Sonic Hedgehog-Glioma-Associated Oncogene 1 Pathway in Gastric Carcinoma Cells
Cancer Res., December 1, 2005; 65(23): 10822 - 10829.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Bjerknes and H. Cheng
Gastrointestinal Stem Cells. II. Intestinal stem cells
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G381 - G387.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Brendolan, E. Ferretti, V. Salsi, K. Moses, S. Quaggin, F. Blasi, M. L. Cleary, and L. Selleri
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny
Development, July 1, 2005; 132(13): 3113 - 3126.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Takamoto, L.-R. You, K. Moses, C. Chiang, W. E. Zimmer, R. J. Schwartz, F. J. DeMayo, M.-J. Tsai, and S. Y. Tsai
COUP-TFII is essential for radial and anteroposterior patterning of the stomach
Development, May 1, 2005; 132(9): 2179 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Stepan, S. Ramamoorthy, H. Nitsche, Y. Zavros, J. L. Merchant, and A. Todisco
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
J. Biol. Chem., April 22, 2005; 280(16): 15700 - 15708.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Gregorieff and H. Clevers
Wnt signaling in the intestinal epithelium: from endoderm to cancer
Genes & Dev., April 15, 2005; 19(8): 877 - 890.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. B. Prasad, A. V. Biankin, N. Fukushima, A. Maitra, S. Dhara, A. G. Elkahloun, R. H. Hruban, M. Goggins, and S. D. Leach
Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells
Cancer Res., March 1, 2005; 65(5): 1619 - 1626.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. Z. Rizvi and M. H. Wong
Epithelial Stem Cells and Their Niche: There's No Place Like Home
Stem Cells, February 1, 2005; 23(2): 150 - 165.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. B. Madison, K. Braunstein, E. Kuizon, K. Portman, X. T. Qiao, and D. L. Gumucio
Epithelial hedgehog signals pattern the intestinal crypt-villus axis
Development, January 15, 2005; 132(2): 279 - 289.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Lepourcelet, L. Tou, L. Cai, J.-i. Sawada, A. J. F. Lazar, J. N. Glickman, J. A. Williamson, A. D. Everett, M. Redston, E. A. Fox, et al.
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
Development, January 15, 2005; 132(2): 415 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. K. Buhman, L. C. Wang, Y. Tang, E. A. Swietlicki, S. Kennedy, Y. Xie, Z.-Y. Liu, L. C. Burkly, M. S. Levin, D. C. Rubin, et al.
Inhibition of Hedgehog Signaling Protects Adult Mice from Diet-Induced Weight Gain
J. Nutr., November 1, 2004; 134(11): 2979 - 2984.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. P. Katz, N. Perreault, B. G. Goldstein, H.-H. Chao, R. P. Ferraris, and K. H. Kaestner
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake
Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G856 - G864.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. Fu, V. C. H. Lui, M. H. Sham, V. Pachnis, and P. K. H. Tam
Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
J. Cell Biol., August 30, 2004; 166(5): 673 - 684.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Fan, C. V. Pepicelli, C. C. Dibble, W. Catbagan, J. L. Zarycki, R. Laciak, J. Gipp, A. Shaw, M. L. G. Lamm, A. Munoz, et al.
Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth
Endocrinology, August 1, 2004; 145(8): 3961 - 3970.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. Moniot, S. Biau, S. Faure, C. M. Nielsen, P. Berta, D. J. Roberts, and P. de Santa Barbara
SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals
Development, August 1, 2004; 131(15): 3795 - 3804.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Gu, J. M. Wells, D. Dombkowski, F. Preffer, B. Aronow, and D. A. Melton
Global expression analysis of gene regulatory pathways during endocrine pancreatic development
Development, January 1, 2004; 131(1): 165 - 179.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. DeYoung, J. C. Baker, D. Cado, and A. Winoto
The Orphan Steroid Receptor Nur77 Family Member Nor-1 Is Essential for Early Mouse Embryogenesis
J. Biol. Chem., November 21, 2003; 278(47): 47104 - 47109.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R. Sacedon, A. Varas, C. Hernandez-Lopez, C. Gutierrez-deFrias, T. Crompton, A. G. Zapata, and A. Vicente
Expression of Hedgehog Proteins in the Human Thymus
J. Histochem. Cytochem., November 1, 2003; 51(11): 1557 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Kawahira, N. H. Ma, E. S. Tzanakakis, A. P. McMahon, P.-T. Chuang, and M. Hebrok
Combined activities of hedgehog signaling inhibitors regulate pancreas development
Development, October 15, 2003; 130(20): 4871 - 4879.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Pola, L. E. Ling, T. R. Aprahamian, E. Barban, M. Bosch-Marce, C. Curry, M. Corbley, M. Kearney, J. M. Isner, and D. W. Losordo
Postnatal Recapitulation of Embryonic Hedgehog Pathway in Response to Skeletal Muscle Ischemia
Circulation, July 29, 2003; 108(4): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
H S Heussler and M Suri
Sonic hedgehog
Mol. Pathol., June 1, 2003; 56(3): 129 - 131.
[Full Text] [PDF]

Home page
 Mol. Pathol.Home page
G R van den Brink, J C H Hardwick, C Nielsen, C Xu, F J ten Kate, J Glickman, S J H van Deventer, D J Roberts, and M P Peppelenbosch
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
Mol. Pathol., June 1, 2003; 56(3): 150 - 155.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B.-e. Wang, J. Shou, S. Ross, H. Koeppen, F. J. de Sauvage, and W.-Q. Gao
Inhibition of Epithelial Ductal Branching in the Prostate by Sonic Hedgehog Is Indirectly Mediated by Stromal Cells
J. Biol. Chem., May 9, 2003; 278(20): 18506 - 18513.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. Lum, S. Yao, B. Mozer, A. Rovescalli, D. Von Kessler, M. Nirenberg, and P. A. Beachy
Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells
Science, March 28, 2003; 299(5615): 2039 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Kawakami, T'N. Kawcak, Y.-J. Li, W. Zhang, Y. Hu, and P.-T. Chuang
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling
Development, March 14, 2003; 129(24): 5753 - 5765.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kanai-Azuma, Y. Kanai, J. M. Gad, Y. Tajima, C. Taya, M. Kurohmaru, Y. Sanai, H. Yonekawa, K. Yazaki, P. P. L. Tam, et al.
Depletion of definitive gut endoderm in Sox17-null mutant mice
Development, March 7, 2003; 129(10): 2367 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. A. Thomson, B. G. Timms, L. Barton, G. R. Cunha, and O. C. Grace
The role of smooth muscle in regulating prostatic induction
Development, March 6, 2003; 129(8): 1905 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Byrd, S. Becker, P. Maye, R. Narasimhaiah, B. St-Jacques, X. Zhang, J. McMahon, A. McMahon, and L. Grabel
Hedgehog is required for murine yolk sac angiogenesis
Development, March 3, 2003; 129(2): 361 - 372.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
G R van den Brink, J C H Hardwick, C Nielsen, C Xu, F J ten Kate, J Glickman, S J H van Deventer, D J Roberts, and M P Peppelenbosch
Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract
Gut, November 1, 2002; 51(5): 628 - 633.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Takamoto, B. Zhao, S. Y. Tsai, and F. J. DeMayo
Identification of Indian Hedgehog as a Progesterone-Responsive Gene in the Murine Uterus
Mol. Endocrinol., October 1, 2002; 16(10): 2338 - 2348.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Aubin, U. Dery, M. Lemieux, P. Chailler, and L. Jeannotte
Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling
Development, September 1, 2002; 129(17): 4075 - 4087.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Bose, L. Grotewold, and U. Ruther
Pallister-Hall syndrome phenotype in mice mutant for Gli3
Hum. Mol. Genet., May 1, 2002; 11(9): 1129 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. K. Gustafsson, H. Pan, D. F. Pinney, Y. Liu, A. Lewandowski, D. J. Epstein, and C. P. Emerson Jr.
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
Genes & Dev., January 1, 2002; 16(1): 114 - 126.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Long, X. M. Zhang, S. Karp, Y. Yang, and A. P. McMahon
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
Development, December 15, 2001; 128(24): 5099 - 5108.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Haraguchi, R. Mo, C.-c. Hui, J. Motoyama, S. Makino, T. Shiroishi, W. Gaffield, and G. Yamada
Unique functions of Sonic hedgehog signaling during external genitalia development
Development, November 1, 2001; 128(21):